为么90%癌症病人亡于复发转移？高清图像带你看清癌细胞转移过程！
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_gif/9CLHn3Vd84OsX7ic4QeLiagMTgYiaVicp5M0FCvRX2Ficu8bEPl7Q5P4my5E1A5pfDggWJTdKh942NAvD4Em1vE88Gw/640?wx_fmt=gif&wxfrom=5&wx_lazy=1&tp=webp" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">你<span style="color: black;">晓得</span>吗？90%的癌症<span style="color: black;">病人</span><span style="color: black;">最后</span>死亡却并非癌症本身，而是癌症的转移！</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">尽管大<span style="color: black;">都数</span>癌症<span style="color: black;">病人</span>接受了治疗，但<span style="color: black;">她们</span>的肿瘤却仍然在继续增长，那它们到底是<span style="color: black;">怎样</span>转移的呢？有<span style="color: black;">无</span>办法让<span style="color: black;">咱们</span>真切的看到肿瘤转移的景象呢？</span></strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">近期<span style="color: black;">发布</span>在《自然评论·癌症》杂志上的一项<span style="color: black;">科研</span>，其中就有多张<span style="color: black;">照片</span><span style="color: black;">能够</span>带领<span style="color: black;">咱们</span>走进神奇的癌症微观世界。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/gDGtvyAnXZB21ayBP5pnWViaQcYbIXLR0osGkEXguJ4BQpHQuWial6yTj00baZTia9bIK96JO1DS8uMARZcaMMuJw/640?wx_fmt=other&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;"></p>肾脏基础影像<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/gDGtvyAnXZB21ayBP5pnWViaQcYbIXLR0t7hN7Kj0ZgQuw8SmyhuNPiciaicFEGHuG1dTSpYEx3piaricfk46vKflYQA/640?wx_fmt=other&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;"></p><span style="color: black;">脉管系统：红色（<span style="color: black;">经过</span>静脉注射的四甲基罗丹明 (TMR) 标记的155-kDa葡聚糖）；亮绿色：巨噬细胞（<span style="color: black;">经过</span>GFP标记）；暗绿色：集合管和小管</span><span style="color: black;">整张<span style="color: black;">照片</span>层次分明，<span style="color: black;">能够</span>清楚地看到肾脏中组织分布的<span style="color: black;">状况</span>。</span>肺部癌细胞图像<img src="https://mmbiz.qpic.cn/mmbiz_png/gDGtvyAnXZB21ayBP5pnWViaQcYbIXLR0uZeQOd6iavkfibKSHfElkaOzsySDNYibnwnxZWrGmJGXr1VYoibM9Txk8g/640?wx_fmt=other&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;"><span style="color: black;">脉管系统：红色（TMR标记）；绿色：转移型的肿瘤细胞（GFP标记） </span><span style="color: black;">整幅画面犹如蜿蜒的火山，其中脉管系统被TMR标记呈现出红色，而红色中的那一抹绿象征的却不是生机，而是吞噬性命的癌细胞。</span>乳腺导管原位癌（DCIS）上皮细胞图像<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/gDGtvyAnXZB21ayBP5pnWViaQcYbIXLR0uCibz7JdUib9ECIcovPAnEdgdw4WRqtqZHLtf1zz7euO8t4iaicicE2Ribsg/640?wx_fmt=other&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;"></p><span style="color: black;">脉管系统：红色（TMR标记）；乳腺上皮细胞：青色（CFP标记）。</span><span style="color: black;">上面<span style="color: black;">照片</span>中，脉管系统由TMR标记呈现出红色，DCIS上皮细胞则被CFP标记呈现出青绿色，像是蓝莓一样，整张<span style="color: black;">照片</span><span style="color: black;">能够</span>清楚看到细胞分布。</span>高分辨率癌症转移全景图<img src="https://mmbiz.qpic.cn/mmbiz_png/gDGtvyAnXZB21ayBP5pnWViaQcYbIXLR0WzwjmUOsErxB7d8Qia61bAfWsibxQRShRvhynjGJLJhsk5bNuQdq0FIg/640?wx_fmt=other&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;"><span style="color: black;">癌细胞大容量、高分辨率的活体<span style="color: black;">影像</span><span style="color: black;">照片</span>。绿色：癌细胞；蓝色：巨噬细胞；青蓝色：胶原纤维；红色：新生血管 </span><span style="color: black;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">上面<span style="color: black;">照片</span>描述的是<span style="color: black;">经过</span>大体积、高分辨率活体<span style="color: black;">影像</span>技术（LVHR-IVI）对乳腺小鼠进行<span style="color: black;">影像</span>后得到的<span style="color: black;">照片</span>，<span style="color: black;">经过</span>静脉注射荧光标记葡萄聚糖（红色）来标记新生的血管，<span style="color: black;">能够</span>区分导管原位癌（DCIS）和晚期癌（LC）区域。整幅<span style="color: black;">照片</span>看上去犹如夏季荷塘，其中新形成的癌细胞<span style="color: black;">起始</span><span style="color: black;">逐步</span>蔓延。</p>
</span><span style="color: black;">在左边的小图上，<span style="color: black;">咱们</span><span style="color: black;">能够</span>更加清晰地看到癌细胞的<span style="color: black;">状况</span>，其中在右上角的e图中，其中标记为N的细胞核，标记为V的为液泡；等到下一个<span style="color: black;">照片</span>f中，就会<span style="color: black;">发掘</span>癌细胞<span style="color: black;">已然</span>随着胶原纤维方向<span style="color: black;">起始</span>流动；在<span style="color: black;">照片</span>g中，<span style="color: black;">咱们</span><span style="color: black;">一样</span><span style="color: black;">能够</span>看到癌细胞正在迁移。</span><span style="color: black;">看完以上<span style="color: black;">照片</span>，<span style="color: black;">咱们</span>再来回顾<span style="color: black;">第1</span>个问题，癌细胞<span style="color: black;">为何</span>会迁移？是<span style="color: black;">怎样</span>迁移的呢？</span><span style="color: black;">俄勒冈州立大学的<span style="color: black;">科研</span>团队<span style="color: black;">近期</span>一篇<span style="color: black;">发布</span>在《科学报告》的<span style="color: black;">科研</span>为<span style="color: black;">咱们</span>带来了最新<span style="color: black;">发展</span>。</span><img src="https://mmbiz.qpic.cn/mmbiz_png/hFbUznRxYqMR4ibiaxgHJtz6Dr68icBS3DtnZNfm0iax6XlrrbPVN2l8UicCWWzicLMQO3knEOdeU5gZMBx2V38SuLOw/640?wx_fmt=other&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;"><span style="color: black;">在长达数十亿年的进化过程中，细胞学会了<span style="color: black;">区别</span>的迁移方式。<span style="color: black;">例如</span>，</span><span style="color: black;"><strong style="color: blue;">在伤口恢复过程中，就会有<span style="color: black;">非常多</span>细胞迁移伤口部位，促进伤口愈合。但令人没想到的是：癌细胞<span style="color: black;">亦</span>会利用这些迁移方式来<span style="color: black;">帮忙</span>自己扩散。</strong></span><span style="color: black;">最新的<span style="color: black;">科研</span>中，<span style="color: black;">科研</span>人员用一种高侵袭性的乳腺癌细胞<span style="color: black;">做为</span><span style="color: black;">科研</span>对象，并<span style="color: black;">经过</span>一种被<span style="color: black;">叫作</span>之为“计算机视觉”的人工智能系统综合分析癌细胞转移的<span style="color: black;">照片</span>、视频，跟踪癌细胞，找到它的迁移途径——细胞的形状和细胞的功能有着密切的联系，<span style="color: black;">例如</span>镰刀型红细胞就失去了红细胞原有的功能。细胞形状的改变<span style="color: black;">亦</span>是<span style="color: black;">咱们</span>鉴别癌细胞的一种<span style="color: black;">要紧</span>的诊断<span style="color: black;">工具</span>。</span>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/hFbUznRxYqMR4ibiaxgHJtz6Dr68icBS3Dt0AMJuiayDib5Vo0ob3Fwrib9VGgQ4ibWNjvsf35Giaek452UMVqHz9HmSsw/640?wx_fmt=other&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">人工智能分析细胞的4种<span style="color: black;">区别</span>运动模式</span></p><span style="color: black;"><span style="color: black;">经过</span>计算机视觉的人工智能<span style="color: black;">科研</span><span style="color: black;">发掘</span>，</span><span style="color: black;"><strong style="color: blue;">在<span style="color: black;">区别</span>的细胞外基质模型中，癌细胞会改变形状和运动状态，<span style="color: black;">能够</span>让自己<span style="color: black;">更易</span>穿过细胞外基质这层“墙”，这<span style="color: black;">针对</span>癌细胞的转移至关<span style="color: black;">要紧</span>。</strong></span><img src="https://mmbiz.qpic.cn/mmbiz_png/hFbUznRxYqMR4ibiaxgHJtz6Dr68icBS3Dthj9b2edS2jCia2sXQHINUMo4Kz1VQTUBOrHkMtfK5XsKruKicVLtxHVw/640?wx_fmt=other&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">细胞形态的改变促进了癌细胞的转移</span></p><span style="color: black;">既然<span style="color: black;">咱们</span><span style="color: black;">发掘</span>了，</span><span style="color: black;"><strong style="color: blue;">癌细胞的“变身”能够辅助它扩散，</strong></span><span style="color: black;"><span style="color: black;">那样</span>，<span style="color: black;">倘若</span>找到<span style="color: black;">掌控</span>癌细胞“变身”的“开关”，没准就<span style="color: black;">能够</span>提前预判癌细胞的转移方向，<span style="color: black;">乃至</span>阻止癌细胞的转移！</span><span style="color: black;">当然，除了人工<span style="color: black;">干涉</span>之外，<span style="color: black;">咱们</span><span style="color: black;">自己</span><span style="color: black;">亦</span>有天然的应对手段。</span><span style="color: black;"><strong style="color: blue;">癌细胞很狡猾，但它<span style="color: black;">亦</span>有天敌——免疫细胞。免疫细胞在身体各处“巡逻”，一旦<span style="color: black;">发掘</span>癌细胞就会动手绞杀，不给癌细胞发展的机会。</strong></span><span style="color: black;">人<span style="color: black;">身体</span>的免疫细胞是<span style="color: black;">咱们</span><span style="color: black;">监测</span>、防御癌细胞的最佳武器。<span style="color: black;">然则</span>，随着年龄增长，免疫细胞会<span style="color: black;">逐步</span>减少、变得活力不足，有<span style="color: black;">有些</span>癌细胞就会逃脱免疫细胞的追杀，<span style="color: black;">逐步</span>发展成癌症。<span style="color: black;">因此呢</span>，尽早存储<span style="color: black;">青年</span>有活力的免疫细胞，以备将来<span style="color: black;">运用</span>之需，是保持身体健康，预防癌症等<span style="color: black;">疾患</span>最宝贵的机会之一。</span><span style="color: black;">中国工程院 陆道培院士曾说：</span><span style="color: black;"><strong style="color: blue;">免疫细胞是<span style="color: black;">咱们</span>人体所<span style="color: black;">必须</span>的细胞，是<span style="color: black;">要紧</span>的细胞，储存起来<span style="color: black;">亦</span><span style="color: black;">便是</span>储存<span style="color: black;">咱们</span>的力量，比储存的钱还要更<span style="color: black;">要紧</span>。</strong></span>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">举荐</span>阅读：</span></p><a style="color: black;"><span style="color: black;">NK细胞——正在<span style="color: black;">作为</span>抗癌免疫疗法的新星</span></a><a style="color: black;"><span style="color: black;">北京协和医院分析了1068人，证明<span style="color: black;">弥补</span>NK细胞必要性</span></a><a style="color: black;"><span style="color: black;">突破性案例：免疫细胞疗法为晚期肝癌<span style="color: black;">病人</span> 带来令人惊喜的变化</span></a><a style="color: black;"><span style="color: black;">2次50亿个NK细胞进入<span style="color: black;">身体</span>后，</span></a>广泛期小细胞肺癌，多发转移缩小、消退！<a style="color: black;"><span style="color: black;">国际视野：NK细胞激发免疫力大杀四方！来<span style="color: black;">瞧瞧</span>日本<span style="color: black;">科研</span><span style="color: black;">发展</span>……</span></a><a style="color: black;"><span style="color: black;">一文讲透：术后<span style="color: black;">弥补</span>免疫细胞，可重建免疫系统，预防癌症转移复发！</span></a>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">声明：本文为知识科普，仅供学习、交流；不<span style="color: black;">表率</span><span style="color: black;">咱们</span>的立场<span style="color: black;">亦</span>不<span style="color: black;">做为</span><span style="color: black;">关联</span>医疗<span style="color: black;">指点</span>或用药<span style="color: black;">意见</span>。<span style="color: black;">：</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">参考资料：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">Entenberg, D., Oktay, M.H. & Condeelis, J.S. Intravital imaging to study cancer progression and metastasis. Nat Rev Cancer (2022). https://doi.org/10.1038/s41568-022-00527-5</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">https://www.nature.com/articles/s41598-021-99902-9</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">21世纪是生命科学的时代，<span style="color: black;">将来</span>干细胞和免疫细胞的应用将<span style="color: black;">作为</span>临床治疗中的<span style="color: black;">平常</span>手段。安全有效的<span style="color: black;">弥补</span><span style="color: black;">身体</span>干细胞和免疫细胞，来调节免疫系统的平衡，将会使人类<span style="color: black;">很久</span>的保持健康态。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">储存健康的干细胞和免疫细胞</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">备份生命的火种</strong></span></p><span style="color: black;"><strong style="color: blue;">- END -</strong></span><span style="color: black;"><strong style="color: blue;">欲<span style="color: black;">认识</span><span style="color: black;">更加多</span>干细胞、免疫细胞<span style="color: black;">关联</span>内容</strong></span><span style="color: black;"><strong style="color: blue;">请拨打美亚贵宾服务热线</strong></span><span style="color: black;"><strong style="color: blue;">4000989888</strong></span>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">↓↓↓</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_jpg/9CLHn3Vd84PYLrdj28fb4KHhX4jB9xDQpwY6bDtNiaThdu8kq7W8TlkSkPUp17AcYAyueRFxvd3pMVyme6tT8vg/640?wx_fmt=other&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;"></p>
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