fny5jt9 发表于 2024-6-28 00:59:15

原创 阿司匹林抗癌再添新证!最新科研:阿司匹林掌控癌症转移新机制


    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q9.itc.cn/q_70/images01/20240508/a7b2ce0e1e574da4a55a3a0baa7a5064.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">阿司匹林是一款神药,数据<span style="color: black;">表示</span>,全世界阿司匹林年消耗量近年来基本维持在5万吨<span style="color: black;">上下</span>,相当于每年服下1500亿片阿司匹林药片。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">为何</span>阿司匹林如此受欢迎?</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1899阿司匹林的发明专利申请被<span style="color: black;">经过</span>,德国拜耳药厂正式生产这种<span style="color: black;">药物</span>,取商品名为Aspirin。一<span style="color: black;">起始</span>阿司匹林<span style="color: black;">重点</span>被用于解热<span style="color: black;">止疼</span>。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1982年,英国<span style="color: black;">专家</span>约翰万<span style="color: black;">发掘</span>阿司匹林的抗凝机制,即抗血小板聚集。1985年美国卫生与民众服务部长玛格丽特宣布“阿司匹林可有效预防二次心梗<span style="color: black;">爆发</span>”;1988年“内科健康医学<span style="color: black;">科研</span>”杂志<span style="color: black;">颁布</span>阿司匹林可能降低心脏病的发病率;1996年FDA(美国食品<span style="color: black;">药物</span>管理局)<span style="color: black;">举荐</span>阿司匹林<span style="color: black;">做为</span>预防心脏病的常规用药。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">因此</span>,<span style="color: black;">此刻</span><span style="color: black;">大众</span>是阿司匹林,<span style="color: black;">重点</span>是为了预防血栓。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">来自世界心脏联盟(WHF)的数据则<span style="color: black;">表示</span>,<span style="color: black;">全世界</span>心血管<span style="color: black;">疾患</span><span style="color: black;">病人</span>人数已超过5亿,想想看,这5亿<span style="color: black;">病人</span>,即便<span style="color: black;">每日</span>每人只吃1片阿司匹林,<span style="color: black;">那样</span>一年下来,要消耗多少片呢?</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">更糟糕的是,随着生活习惯的改变,心血管<span style="color: black;">疾患</span>的发病率越来越高,这<span style="color: black;">亦</span><span style="color: black;">引起</span>了阿司匹林的消耗量越来越多。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">可是,除了能抗血小板聚集以外,阿司匹林还有一个<span style="color: black;">功效</span>,却是<span style="color: black;">非常多</span>人不<span style="color: black;">晓得</span>的,这个<span style="color: black;">功效</span><span style="color: black;">便是</span>,阿司匹林还<span style="color: black;">能够</span><span style="color: black;">控制</span>癌症。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">早在2020年《柳叶刀》就曾刊登过<span style="color: black;">关联</span><span style="color: black;">文案</span>,<span style="color: black;">暗示</span><span style="color: black;">吃下</span>阿司匹林可降低结肠癌发病率,高危人群发病<span style="color: black;">危害</span>减半,<span style="color: black;">况且</span>这种预防效果可维持10~20年,<span style="color: black;">因此呢</span>入选了最有<span style="color: black;">期盼</span>预防结直肠癌的<span style="color: black;">药品</span>之一。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">德国慕尼黑大学的<span style="color: black;">科研</span>人员在《Cell Death &amp; Disease》上刊登的<span style="color: black;">发布</span>的一篇<span style="color: black;">科研</span><span style="color: black;">文案</span>,为此再添新证。<span style="color: black;">科研</span><span style="color: black;">发掘</span>,阿司匹林经过水解会转化为水杨酸,<span style="color: black;">经过</span>激活<span style="color: black;">控制</span>诱癌基因的表达,诱导AMPK并<span style="color: black;">控制</span>c-MYC,从而下调了结直肠癌转移进程。教授<span style="color: black;">暗示</span>,这项<span style="color: black;">科研</span>提示阿司匹林在<span style="color: black;">将来</span>或能用于治疗结直肠癌,实现<span style="color: black;">控制</span>癌细胞迁移和侵袭。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">鉴于阿司匹林在预防结直肠癌上的<span style="color: black;">优良</span>,<span style="color: black;">此刻</span><span style="color: black;">针对</span>有肠癌高危<span style="color: black;">危害</span><span style="color: black;">原因</span>的人群,是<span style="color: black;">能够</span>尝试<span style="color: black;">运用</span>阿司匹林<span style="color: black;">亦</span>预防肠癌的。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">不外</span><span style="color: black;">亦</span>有人提出了质疑,<span style="color: black;">大夫</span>,是药三分毒,就更<span style="color: black;">不消</span>说阿司匹林了,众所周知,阿司匹林之<span style="color: black;">因此</span>伤胃,是<span style="color: black;">由于</span>它<span style="color: black;">控制</span>了COX-1,<span style="color: black;">亦</span><span style="color: black;">叫作</span>环氧化酶-1,这种酶存在于胃肠黏膜里,能促进前列腺素的合成,而前列腺素能够<span style="color: black;">守护</span>胃肠黏膜,<span style="color: black;">长时间</span>服用阿司匹林,<span style="color: black;">引起</span>环氧化酶-1被<span style="color: black;">长时间</span><span style="color: black;">控制</span>,前列腺素生成减少,当然<span style="color: black;">有害</span>于胃肠黏膜的修复,<span style="color: black;">出现</span>消化性溃疡的<span style="color: black;">危害</span>就很高了。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">因此</span>,<span style="color: black;">非常多</span>人<span style="color: black;">长时间</span><span style="color: black;">吃下</span>阿司匹林,可能会<span style="color: black;">发掘</span>吃着吃着就<span style="color: black;">流血</span>了,<span style="color: black;">针对</span>老年人而言,严重的消化道<span style="color: black;">流血</span><span style="color: black;">乃至</span>有可能致命。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">做为</span><span style="color: black;">大夫</span>,我想说的是,要不要<span style="color: black;">吃下</span>阿司匹林来预防肠癌,<span style="color: black;">重点</span>看<span style="color: black;">病人</span>的年龄,有些<span style="color: black;">病人</span>已经八十岁了,这个时候为了预防肠癌,去<span style="color: black;">吃下</span>阿司匹林,一旦<span style="color: black;">引起</span>大<span style="color: black;">流血</span>,<span style="color: black;">常常</span>会致命,<span style="color: black;">因此</span><span style="color: black;">吃下</span>阿司匹林的<span style="color: black;">危害</span>太大,这个时候,单纯为了预防结直肠癌去吃阿司匹林,显然是不可取的。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">可<span style="color: black;">倘若</span><span style="color: black;">针对</span>70岁以下的人群而言,<span style="color: black;">因为</span>形形色色的<span style="color: black;">原由</span><span style="color: black;">引起</span>肠癌的发病率很高,<span style="color: black;">例如</span>遗传,这个时候去<span style="color: black;">吃下</span>阿司匹林,获益是大于<span style="color: black;">害处</span>,是<span style="color: black;">能够</span><span style="color: black;">思虑</span>服用的,<span style="color: black;">然则</span><span style="color: black;">吃下</span>的时候,要<span style="color: black;">尤其</span>关注自己的胃,<span style="color: black;">由于</span>阿司匹林对胃的<span style="color: black;">损害</span>是比<span style="color: black;">很强</span>的。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">北京大学<span style="color: black;">第1</span>医院刘梅林等人在《中国循环杂志》上<span style="color: black;">发布</span>了一项<span style="color: black;">科研</span>成果,这项<span style="color: black;">科研</span><span style="color: black;">重点</span>是针对<span style="color: black;">吃下</span>阿司匹林的60岁以上的老年人。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这些人<span style="color: black;">重点</span><span style="color: black;">能够</span>分为两种,一种是165名<span style="color: black;">病人</span>,<span style="color: black;">每日</span><span style="color: black;">吃下</span>50毫克的阿司匹林,另一种是216名<span style="color: black;">每日</span><span style="color: black;">吃下</span>100毫克的阿司匹林。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">最后</span><span style="color: black;">按照</span>相应的数据<span style="color: black;">表示</span>,<span style="color: black;">倘若</span><span style="color: black;">每日</span><span style="color: black;">吃下</span>50和100毫克的人都<span style="color: black;">能够</span>起到<span style="color: black;">控制</span>花生四稀酸诱导的血小板聚集率。<span style="color: black;">然则</span><span style="color: black;">每日</span><span style="color: black;">倘若</span><span style="color: black;">吃下</span>100毫克的阿司匹林,会比50毫克的人群<span style="color: black;">显现</span>轻微<span style="color: black;">流血</span>的<span style="color: black;">危害</span><span style="color: black;">增多</span>73.8%,总<span style="color: black;">流血</span>的<span style="color: black;">危害</span>率<span style="color: black;">亦</span>会<span style="color: black;">增多</span>67.1%。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">因此</span>,<span style="color: black;">倘若</span>害怕阿司匹林<span style="color: black;">引起</span>的副<span style="color: black;">功效</span>,<span style="color: black;">那样</span>在服阿司匹林的时候,<span style="color: black;">能够</span>适当减少阿司匹林的用量。<a style="color: black;"><span style="color: black;">返回<span style="color: black;">外链论坛:http://www.fok120.com/</span>,查看<span style="color: black;">更加多</span></span></a></p>

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nqkk58 发表于 2024-11-3 17:42:54

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