6hz7vif 发表于 2024-5-25 00:35:53

最新科研:外泌体是一种潜在的癌症生物疗法


    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_jpg/l0qUVck8eg8NmpAqC1AfzblGXlcLsHbF3Ks14bZYfFLJ1zooawNOTcngbOPMnBOpu9pz12cP0UmkzEJmJ9LXvw/640?wx_fmt=jpeg&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/k5ejyH9nkCst4a7LcqV5icWuI2BicSpicam2rglQTKPvr5dLPwic5Mnym9RPlaQnmN3690BKcRf3YGznSgZbbLjFYQ/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_gif/aNeBAw185rh0DrnDC7DbEZHTvcJPyPFgIalbTiarjNwFzr2nLB4cKMxxVIZic1GZJxXDwp5PSoV2DxCV1NSvAia0w/640?wx_fmt=gif&amp;wxfrom=5&amp;wx_lazy=1&amp;tp=webp" style="width: 50%; margin-bottom: 20px;"></p><span style="color: black;"><strong style="color: blue;">关注<span style="color: black;">咱们</span>,<span style="color: black;">认识</span><span style="color: black;">更加多</span>科普<span style="color: black;">新闻</span>!</strong></span>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">外泌体治疗膀胱癌</strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">2022年8月23日,由复旦大学<span style="color: black;">附庸</span>浦东医院肿瘤医学中心(肿瘤科、泌尿外科)、中国科学院过程工程<span style="color: black;">科研</span>所<span style="color: black;">一起</span>举办的“</span><strong style="color: blue;">嵌合外泌体型肿瘤疫苗治疗复发或转移膀胱癌的开放、剂量递增的临床<span style="color: black;">科研</span></strong><span style="color: black;">”<span style="color: black;">起步</span>会以线下、线上结合的形式顺利召开。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_jpg/l0qUVck8eg94iatHF4uPHlu0k6TKBxOSFmvN14w4DU6nrTvPDArHH1LZiaGCDt4BOiaDQEnVibe8jFox0ibA0gLeapw/640?wx_fmt=jpeg&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></span></a></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">脂肪间充质干细胞外泌体治疗乳腺癌</strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">发布</span>于《scientific reports》的一篇<span style="color: black;">文案</span><span style="color: black;">亦</span>展示了</span></strong><strong style="color: blue;">脂肪间充质干细胞外泌体<span style="color: black;">控制</span>耐药三阴性乳腺癌生长的潜在治疗<span style="color: black;">功效</span></strong><strong style="color: blue;"><span style="color: black;">。这项<span style="color: black;">科研</span>得出结论:间充质干细胞外泌体是一种潜在的乳腺癌生物疗法,<span style="color: black;">能够</span><span style="color: black;">做为</span>其他标准治疗的<span style="color: black;">弥补</span>疗法,以<span style="color: black;">供给</span>更好的疗效,而不会<span style="color: black;">显现</span>不良反应。</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_png/l0qUVck8eg94iatHF4uPHlu0k6TKBxOSFGEg7fqQuqUzOTEicOicf2ibsvGCria7rYLddbklFGToYu858fEic7YHpwPw/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></span></a></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">外泌体治疗癌症及衰老<span style="color: black;">关联</span><span style="color: black;">疾患</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">有学者在国际期刊《Biotechnology Reports 》<span style="color: black;">发布</span>综述,<span style="color: black;">仔细</span>介绍了</span></strong><strong style="color: blue;">间充质干细胞<span style="color: black;">源自</span>外泌体在癌症及衰老<span style="color: black;">关联</span><span style="color: black;">疾患</span>的治疗<span style="color: black;">科研</span>中的最新<span style="color: black;">发展</span></strong><strong style="color: blue;"><span style="color: black;">,从外泌体的<span style="color: black;">源自</span>和<span style="color: black;">构成</span>、<span style="color: black;">药品</span>传递效果、免疫调节特性、肿瘤治疗以及延缓衰老等方面的应用进行阐述,认为间充质干细胞外泌体有<span style="color: black;">潜能</span><span style="color: black;">作为</span>一种新兴的肿瘤治疗<span style="color: black;">方法</span>,以及<span style="color: black;">作为</span>抗衰老<span style="color: black;">科研</span>的新风向。</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_png/l0qUVck8eg94iatHF4uPHlu0k6TKBxOSFsYTI8NJ7CxibBsFRUiaNF04SESWlBr83uf9zfHAsW2TBvRZ9VUmIRvQQ/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></span></a></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">NK细胞外泌体杀死肺癌癌细胞</strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">密歇根大学罗杰尔癌症中心和密歇根大学工程学院的<span style="color: black;">科研</span>人员基于新兴疗法开展了<strong style="color: blue;">人体自然杀伤细胞(NK细胞)来对抗癌症</strong>,又向前迈进了一步。对来自五名肺癌<span style="color: black;">病人</span>的血液样本进行的一项验证<span style="color: black;">科研</span><span style="color: black;">显示</span>,该<span style="color: black;">办法</span>能够在微流控芯片上<span style="color: black;">捕捉</span>自然杀伤细胞,并利用它们来“培育”NK 外泌体。<span style="color: black;">按照</span><span style="color: black;">发布</span>在“Advanced Science”上的<span style="color: black;">科研</span>结果,<span style="color: black;">包含</span> U-M 工程师和肿瘤学家在内的多学科团队进一步证明,外泌体<span style="color: black;">能够</span>有效杀死细胞培养物中的循环肿瘤细胞。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_png/l0qUVck8eg94iatHF4uPHlu0k6TKBxOSF5ibRXxEDZ1EV8BUcGABdmz0eJAs1Wu1ibg3gQKc0f34ER1tpxMibctcSQ/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></span></a></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">中性粒细胞外泌体抗肿瘤</strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">2022年1月12日,江苏大学医学院张徐团队等在 Science 子刊 Science Advances <span style="color: black;">发布</span>了题为:Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy 的<span style="color: black;">科研</span>论文。<span style="color: black;">科研</span><span style="color: black;">研发</span>了一种简单<span style="color: black;">有效</span>的工程化中性粒细胞<span style="color: black;">源自</span>的外泌体(N-Ex)和中性粒细胞<span style="color: black;">源自</span>的纳米囊泡(NNV),可<span style="color: black;">做为</span>一种安全有效的肿瘤治疗的<span style="color: black;">药品</span>递送载体。</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_png/l0qUVck8eg94iatHF4uPHlu0k6TKBxOSFKILArOIObrRcfckD29zNh1ZF04FEee89Mico1vfZpvta1dGQASrwa8Q/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></span></a></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">外泌体是什么?</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">外泌体<span style="color: black;">(exosome)</span><span style="color: black;">指的是</span>细胞向外分泌的小囊泡,<span style="color: black;">一般</span>为直径为30-150nm。外泌体中<span style="color: black;">包括</span>了蛋白质、脂质、RNA等物质,能够被受体细胞接收,实现细胞间的物质运输和信息传递。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">外泌体的形成、分泌与被吸收是个相当<span style="color: black;">繁杂</span>的过程,<span style="color: black;">能够</span>理解为某国想要与其他国家交流,先要花费<span style="color: black;">非常多</span>的精力来陪养一个使者,使者再做好充足的准备后携带贡品及信息前往其他国家,<span style="color: black;">最后</span>将东西<span style="color: black;">所有</span>交给其他国家。</p><a style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/sz_mmbiz_png/QyfZ0Msic7cm76aadncvia81H6EdR0frKOLme3bOYASQnXvjPjvugx6RImHq0ND5jNfLiaD7P414Q9FuRdmYrs44w/640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1&amp;tp=webp" style="width: 50%; margin-bottom: 20px;"></span></a>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">外泌体形成及分泌过程</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">几乎所有类型的细胞都<span style="color: black;">能够</span>分泌外泌体,<span style="color: black;">同期</span>外泌体还广泛存在于体液、血液、泪液、唾液、尿液、胸腹水中。<span style="color: black;">重点</span>功能<span style="color: black;">包含</span>参与机体免疫应答、抗原呈递、细胞分化、促进病毒感染与传播等。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">外泌体与癌细胞</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌细胞分泌的外泌体为癌细胞的<span style="color: black;">出现</span>与发展<span style="color: black;">供给</span>了巨大的<span style="color: black;">帮忙</span><span style="color: black;">功效</span>:</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">1.&nbsp;促进癌细胞的增殖</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌细胞会释放携带致癌因子<span style="color: black;">(<span style="color: black;">包含</span>蛋白质、核酸等)</span>的外泌体,该外泌体转运到受体细胞,可使受体细胞癌变,从而起到癌细胞的增殖<span style="color: black;">功效</span>;癌细胞还会释放携带细胞凋亡因子的外泌体,不仅<span style="color: black;">能够</span>降低<span style="color: black;">自己</span>细胞凋亡的活性,还会使接收外泌体的受体细胞凋亡,为癌细胞的增殖<span style="color: black;">供给</span><span style="color: black;">更加多</span>空间与养分。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">2.&nbsp;<span style="color: black;">帮忙</span>癌细胞逃脱免疫系统或<span style="color: black;">药品</span>清除</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌细胞分泌的外泌体<span style="color: black;">能够</span><span style="color: black;">经过</span>激活骨髓<span style="color: black;">源自</span>的<span style="color: black;">控制</span>性细胞<span style="color: black;">(MDSC)</span>来<span style="color: black;">控制</span>T细胞的免疫应答;<span style="color: black;">亦</span><span style="color: black;">能够</span><span style="color: black;">经过</span>破坏肿瘤抗原呈递过程来降低免疫应答;<span style="color: black;">同期</span>外泌体还<span style="color: black;">能够</span>促进免疫细胞的凋亡。三方发力使得免疫系统有力<span style="color: black;">亦</span>使不出,只能任由癌细胞增殖、扩散。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">外泌体还<span style="color: black;">能够</span>将<span style="color: black;">药品</span>从癌细胞内转移至癌细胞外,从而减少<span style="color: black;">药品</span>对癌细胞的毒性;已<span style="color: black;">得到</span>耐药性的癌细胞可将耐药因子<span style="color: black;">经过</span>外泌体传递给其他<span style="color: black;">更加多</span>的癌细胞,以此来逃脱<span style="color: black;">药品</span>攻击。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">3.&nbsp;为癌细胞扩散创造有利环境</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">外泌体还<span style="color: black;">能够</span><span style="color: black;">作为</span>癌细胞增殖过程中的侦察兵,它<span style="color: black;">经过</span>体液、血液等进入到不同的组织,为癌细胞<span style="color: black;">创立</span>起<span style="color: black;">能够</span>生长的微环境。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在癌细胞向淋巴结的扩散中最为<span style="color: black;">平常</span>。癌细胞淋巴结分泌<span style="color: black;">海量</span>外泌体先行打好地基,之后便可顺利转移过去。</p><a style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/sz_mmbiz_png/QyfZ0Msic7cm76aadncvia81H6EdR0frKOauDMAvraRHkFkLZXk8Xt3nad4qJR0Swn9syum6nwZakazWc5REDKDg/640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1&amp;tp=webp" style="width: 50%; margin-bottom: 20px;"></span></a>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">结直肠癌外泌体中的miR-25-3p参与肿瘤转移前微环境形成</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">外泌体与癌症诊断</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">外泌体这个“<span style="color: black;">走狗</span>”确实作恶多端,罪大当诛。但其实只要<span style="color: black;">咱们</span>给它正确的引导,它还是能改邪归正,<span style="color: black;">帮忙</span><span style="color: black;">咱们</span>诊断和治疗癌症。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">1.&nbsp;用于癌症诊断</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">前面说到了外泌体<span style="color: black;">包括</span>了细胞的蛋白质、核酸等物质,并且这些物质<span style="color: black;">拥有</span>特异性,<span style="color: black;">那样</span><span style="color: black;">咱们</span>就<span style="color: black;">能够</span>把外泌体当做癌症诊断的分子标志物。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">外泌体蛋白标志物检测以及核酸标志物检测可用于多种癌症的<span style="color: black;">初期</span>诊断与预后复发<span style="color: black;">危害</span>的<span style="color: black;">评定</span>。例如<span style="color: black;">针对</span>肺癌<span style="color: black;">病人</span>检测外泌体CD151、CD171、TSPAN8<span style="color: black;">能够</span><span style="color: black;">得到</span>更为准确的癌症诊断结果;外泌体中的miR-21、miR-1246等核酸<span style="color: black;">能够</span><span style="color: black;">做为</span>乳腺癌检测的标志物。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">因为</span>外泌体还<span style="color: black;">海量</span>存在于人<span style="color: black;">身体</span>的<span style="color: black;">各样</span>体液中,在血液、尿液、腹水、胸水等中可直接获取得到外泌体,这就使得外泌体可用于液体活检中,而外泌体检测的优点<span style="color: black;">包含</span>:样本易得,覆盖癌种广泛,特异性较好,稳定性强。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">2.&nbsp;用于癌症治疗</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">外泌体不仅<span style="color: black;">能够</span>用于癌症的诊断与预后<span style="color: black;">危害</span>的监测还可用于癌症的治疗。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">外泌体可<span style="color: black;">做为</span>癌症治疗<span style="color: black;">药品</span>的载体,<span style="color: black;">传送</span>给癌细胞。将载入核酸、蛋白质、脂质、小分子化合物等抗癌<span style="color: black;">成份</span>的外泌体再导入<span style="color: black;">病人</span><span style="color: black;">身体</span>,外泌体可<span style="color: black;">经过</span>体液进入到全身的癌细胞中,实现癌细胞的杀灭工作。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">树突状细胞分泌的外泌体经过改造可激活抗肿瘤的免疫系统;肿瘤来源的外泌体可<span style="color: black;">做为</span>抗原递送系统阻止自体肿瘤的发展。</p><a style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/sz_mmbiz_png/QyfZ0Msic7cm76aadncvia81H6EdR0frKOibH0rgDhHtQBMMcSibwaNibia2lKUts8fLqGiaONUIu9RiczjSm0cfv2FCCg/640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1&amp;tp=webp" style="width: 50%; margin-bottom: 20px;"></span></a>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">外泌体在肿瘤免疫中的功能</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">除了好好利用<span style="color: black;">亦</span><span style="color: black;">能够</span>直接杀死<span style="color: black;">帮忙</span>癌细胞<span style="color: black;">出现</span>的外泌体,<span style="color: black;">经过</span>清除癌细胞生成的外泌体,解除其对免疫系统的<span style="color: black;">控制</span>,<span style="color: black;">能够</span>实现癌症的治疗<span style="color: black;">功效</span>。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">最神奇的是还<span style="color: black;">能够</span>将外泌体<span style="color: black;">做为</span>靶向药的靶点<span style="color: black;">运用</span>,<span style="color: black;">经过</span>靶向药<span style="color: black;">控制</span>外泌体的合成与分泌,从而阻止外泌体被其他细胞接收。</p><a style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/sz_mmbiz_png/QyfZ0Msic7cm76aadncvia81H6EdR0frKO1pHSu593LPTPPvcbyfFd8iaqNs9RTsEq98JiaVI4XtSH76A5Zn4GabhA/640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1&amp;tp=webp" style="width: 50%; margin-bottom: 20px;"></span></a>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">外泌体在癌症治疗中的应用</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">干细胞及其外泌体治疗癌症</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">近年来,干细胞疗法在再生医学<span style="color: black;">行业</span>取得了许多突破性的<span style="color: black;">发展</span>,适应症<span style="color: black;">持续</span><span style="color: black;">增多</span>。其在癌症治疗中的应用<span style="color: black;">亦</span>在<span style="color: black;">持续</span>探索中。干细胞<span style="color: black;">能够</span>产生<span style="color: black;">有些</span>因子,如TNF-α<span style="color: black;">关联</span>的凋亡诱导配体(TRAIL)和IFN-β,这两种因子都<span style="color: black;">能够</span><span style="color: black;">控制</span>癌症。</p>

    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">其中,干细胞<span style="color: black;">源自</span>的外泌体<span style="color: black;">逐步</span>受到<span style="color: black;">大众</span>的<span style="color: black;">注意</span>。其不仅<span style="color: black;">能够</span>避免同种异体移植免疫排斥反应,还<span style="color: black;">能够</span>在实验室的受控<span style="color: black;">前提</span>下提取,<span style="color: black;">乃至</span>可能进行工程化生产。因<span style="color: black;">包括</span>有益的抗癌因子,将来有可能<span style="color: black;">作为</span>一种更<span style="color: black;">靠谱</span>的癌症生物治疗<span style="color: black;">办法</span>。</p>

    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">从https://clinicaltrials.gov/<span style="color: black;">网</span><span style="color: black;">咱们</span><span style="color: black;">发掘</span><span style="color: black;">日前</span>临床上有4000余项与干细胞<span style="color: black;">关联</span>的癌症治疗登记在案,这<span style="color: black;">亦</span>从侧面反映出干细胞<span style="color: black;">针对</span>癌症治疗的巨大<span style="color: black;">潜能</span>。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_png/ORSickN0ib1kibZD2zmMian7bsOsjgVuSGbE0Q0O2js7Eb97R1S0E7fuibZ0iamcncWtZuFXSowNWgt7U7fRJDUPrL0g/640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1&amp;tp=webp" style="width: 50%; margin-bottom: 20px;"></span></a></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">一项<span style="color: black;">科研</span><span style="color: black;">发掘</span>,<strong style="color: blue;">间充质干细胞<span style="color: black;">能够</span><span style="color: black;">经过</span>调节肿瘤微环境中的免疫<span style="color: black;">成份</span>来减缓癌症的<span style="color: black;">发展</span>。</strong>在结直肠癌大鼠模型中接受间充质干细胞给药,不仅能减少肿瘤的生长,还够减少放疗<span style="color: black;">关联</span>组织<span style="color: black;">损害</span>。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">另外</span>,干细胞用于癌症治疗的另一途径是<span style="color: black;">经过</span>分化为能够攻击癌细胞的细胞。这方面<span style="color: black;">科研</span>较多的是诱导多能干细胞(iPSC),<span style="color: black;">日前</span>,iPSC已成功分化出<span style="color: black;">拥有</span>攻击癌细胞能力的NK细胞,NKT细胞等,<span style="color: black;">关联</span>实验正在抓紧进行中。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">小结</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌症治疗仍然是<span style="color: black;">日前</span>医学界的一大<span style="color: black;">困难</span>。近年来,<span style="color: black;">海量</span>新的治疗<span style="color: black;">办法</span>正在<span style="color: black;">科研</span>中,其中<span style="color: black;">包含</span>干细胞及其衍生物。从<span style="color: black;">以上</span><span style="color: black;">科研</span><span style="color: black;">咱们</span><span style="color: black;">亦</span><span style="color: black;">能够</span>看出,<span style="color: black;">没</span>论是单独<span style="color: black;">运用</span>还是与标准疗法联合<span style="color: black;">运用</span>,干细胞外泌体均<span style="color: black;">表示</span>出强大的肿瘤<span style="color: black;">控制</span>特性,这<span style="color: black;">显示</span>将来有可能是一种潜在的癌症治疗<span style="color: black;">方法</span>。</p>

    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">不外</span>,<span style="color: black;">日前</span>的<span style="color: black;">科研</span>结论仍然处在临床前<span style="color: black;">周期</span>,<span style="color: black;">将来</span>还<span style="color: black;">必须</span>进行更深入的<span style="color: black;">基本</span><span style="color: black;">科研</span>以<span style="color: black;">知道</span>其<span style="color: black;">功效</span>机理以及进行<span style="color: black;">更加多</span>的动物及临床<span style="color: black;">实验</span>以验证其安全与有效性,来推动干细胞及其外泌体在癌症生物疗法<span style="color: black;">行业</span>的<span style="color: black;">科研</span>与应用。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">往期回顾</strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_png/l0qUVck8eg9Tic0O389c2hM820iboLHiazO9eJ8a3Qiaqvk4Z8gKLG2hKrmx8lXAIfLSrEicx5qTNxjQ5Yib3vljRNrA/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></span></a></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;">央视《对话》栏目:干细胞</a>,勇闯<span style="color: black;">没</span>人区!</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_png/l0qUVck8eg8H9ZjDdHTHz9EPhkSLyzChnb1kIp302k2Cyiau6icPLGONMiabY2TcKDBu7qfZn7qgXhjxc2wDiajGUw/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></span></a></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;">身体何时应当进行干细胞修复,修复后能带来<span style="color: black;">那些</span>变化?</a></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_jpg/l0qUVck8eg8HUxxsA1w6BpXIDnBTW8RsiaoKNwvVxd1ias62gmgh1bOrPaH46dTgOoacWV4gwEQwYzAz9MJibnAtg/640?wx_fmt=jpeg&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/WRGz2LWLARBJ8ibFpAa8YeiamVJDa9Gsxm17Nx5fFibicfKg0Vk62BAb0emEH1uicESudgDyu03icvUJict9u09WnDprg/640?wx_fmt=gif&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></p><img src="https://mmbiz.qpic.cn/mmbiz_gif/l0qUVck8eg8NmpAqC1AfzblGXlcLsHbFASM31etdUz4RoNhzkZaQ3qIia7DDGD211YwuR2oXAoPGReG8fbzNC1A/640?wx_fmt=gif&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1" style="width: 50%; margin-bottom: 20px;">
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_gif/l0qUVck8eg8bVBCzsaHDsUb978GJ1ib1lhx4EZI8R2X4m54et9ahvibIWZX8rgzIRCCNpqnop5gJ2adSR5UP9ukA/640?wx_fmt=gif&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1" style="width: 50%; margin-bottom: 20px;"></p>




情迷布拉格 发表于 2024-9-8 08:23:13

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j8typz 发表于 2024-9-29 04:54:03

你的言辞如同繁星闪烁,点亮了我心中的夜空。

b1gc8v 发表于 2024-10-11 23:21:01

太棒了、厉害、为你打call、点赞、非常精彩等。
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