最新信息,癌症治疗或有新办法
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">据新华社3月26日<span style="color: black;">报告</span>,日本<span style="color: black;">科研</span>人员在新一期的英国《自然》杂志上<span style="color: black;">发布</span>了一篇报告<strong style="color: blue;">,<span style="color: black;">叫作</span><span style="color: black;">她们</span>探明一种蛋白质检测脱氧核糖核酸(DNA)链条断裂并<span style="color: black;">起步</span>修复的机制,这有助于<span style="color: black;">科研</span>某些癌症的发病<span style="color: black;">原由</span>并寻找新疗法。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q6.itc.cn/q_70/images03/20240327/6871634b41d44fc39938a8a88d743c27.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">DNA双螺旋结构图图示(图源:澎湃<span style="color: black;">资讯</span>)</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">资料<span style="color: black;">表示</span>,DNA分子是双螺旋结构,很容易受到细胞新陈代谢、毒素和紫外线的破坏。然而,<strong style="color: blue;">大部分<span style="color: black;">损害</span><span style="color: black;">能够</span>由细胞<span style="color: black;">自己</span>修复。<span style="color: black;">仅有</span>修复失败时,才可能会<span style="color: black;">引起</span><span style="color: black;">疾患</span>,<span style="color: black;">乃至</span>癌症。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">以往<span style="color: black;">科研</span><span style="color: black;">发掘</span>,当DNA<span style="color: black;">显现</span>断裂后,一种名为RAD51的蛋白质能<span style="color: black;">帮忙</span>修复。<span style="color: black;">然则</span>,“DNA修复机制是<span style="color: black;">怎么样</span><span style="color: black;">功效</span>的”“这些细胞<span style="color: black;">怎样</span>在未损坏的DNA中快速搜索并找到罕见的<span style="color: black;">损害</span>区域”等问题尚待<span style="color: black;">处理</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">此次的<span style="color: black;">科研</span>则<span style="color: black;">运用</span>冷冻电镜,观察到了这种蛋白质<span style="color: black;">怎样</span>检测断裂并进行修复的<span style="color: black;">繁杂</span>过程,其中,蛋白质RAD51上的氨基末端结构域<span style="color: black;">针对</span>识别断裂位点非常<span style="color: black;">要紧</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">日本东京大学<span style="color: black;">颁布</span><span style="color: black;">资讯</span>公报说,<strong style="color: blue;"><span style="color: black;">非常多</span>癌症<span style="color: black;">病人</span>被<span style="color: black;">检测</span>出其<span style="color: black;">身体</span>蛋白质RAD51的氨基末端结构域<span style="color: black;">出现</span>变异,这可能使得<span style="color: black;">她们</span><span style="color: black;">身体</span>的DNA断裂<span style="color: black;">不可</span>被修复并<span style="color: black;">引起</span>癌症。</strong><span style="color: black;">这次</span><span style="color: black;">科研</span>成果将有助于更好地理解<span style="color: black;">关联</span>癌症的发病<span style="color: black;">原由</span>,并进一步<span style="color: black;">帮忙</span><span style="color: black;">研发</span>治疗<span style="color: black;">办法</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q9.itc.cn/q_70/images03/20240327/86a8a49cb19743daa48db5e71ac8f675.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">研究</span>人员正在做基因<span style="color: black;">科研</span>(图源:中国日报)</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">事实上,DNA修复<span style="color: black;">始终</span><span style="color: black;">败兴</span>都是科学界的热门<span style="color: black;">专题</span>。2015年的诺贝尔化学奖<span style="color: black;">便是</span>颁发给<span style="color: black;">科研</span>“DNA修复的细胞机制”的三位<span style="color: black;">专家</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">此后,<strong style="color: blue;"><span style="color: black;">相关</span>“DNA修复机制”的<span style="color: black;">科研</span>层出不穷</strong>。有的<span style="color: black;">科研</span><span style="color: black;">显示</span>“DNA移动与其<span style="color: black;">损害</span>反应和自我修复能力<span style="color: black;">相关</span>”;有的<span style="color: black;">科研</span><span style="color: black;">发掘</span>“RNA聚合酶是组装<span style="color: black;">全部</span>NER复合体的支架”;还有的<span style="color: black;">经过</span><span style="color: black;">科研</span>弓头鲸细胞中CIRBP蛋白质以揭示“何种蛋白质能够<span style="color: black;">加强</span>DNA修复效率”。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">当然,修复DNA听起来简单,其实是个大工程。<strong style="color: blue;">专家在对斑马鱼<span style="color: black;">科研</span>的过程中<span style="color: black;">发掘</span>,其实修复DNA的有效方式<span style="color: black;">便是</span>“睡觉</strong>”,<span style="color: black;">原由</span>在于动物(斑马鱼)睡觉时Parp1蛋白的工作效率比<span style="color: black;">白日</span>高,<span style="color: black;">因此呢</span>在实验中Parp1蛋白使动物(斑马鱼)睡得更香、更长,从而促进<span style="color: black;">更加多</span>的受损DNA被修复。<strong style="color: blue;"><span style="color: black;">将来</span>,这项<span style="color: black;">科研</span><span style="color: black;">发展</span><span style="color: black;">能够</span>进一步延伸至人类身上。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">源自</span>:</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">新华社、科技日报、北京科学中心、</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">中国科技部生物中心、中国科学院官网</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">编审:加欣、苏永生、甘勇</span></p>
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