60%中国人都能用得起的癌症治疗法,将在十年之内显现
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">造就,<span style="color: black;">发掘</span>最有创造力的思想</strong></p><img src="https://mmbiz.qpic.cn/mmbiz_png/Jo4d3t8GbiavT4KibEgQia77DhOtZicUjcSOKhJogIdyHkJb0EqT3ZbhhCia8iaEmEcU17jEcfnNXGj5OXV4DuoJvHwg/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">钱其军</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">上海细胞治疗<span style="color: black;">科研</span>院院长</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">上海细胞治疗工程技术<span style="color: black;">科研</span>中心<span style="color: black;">专家</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">以前美国有一本书叫做《众病之王癌症传》。什么叫众病之王,从概念上来讲,是严重<span style="color: black;">害处</span>人类健康的<span style="color: black;">疾患</span>,而<span style="color: black;">此刻</span>又<span style="color: black;">无</span>一个非常好的办法来对付它。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">那样</span>,<span style="color: black;">日前</span>科学界对癌症的认知是怎么样的?在<span style="color: black;">近期</span>一段时间内,有<span style="color: black;">无</span>一个较好的治疗方法。大热的免疫疗法<span style="color: black;">针对</span>治疗癌症<span style="color: black;">可否</span>有效?</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz/Jo4d3t8GbiasYF8BSUDJkJ2rKMpxRxm40G5zAEEKw6NQj9sqWON7dATHprFJu8jcASz3KhHEokuXGff6ia908t7A/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">首要</span>来看,每年癌症的新发病病例在中国将近430万人,每年死亡在280万人。在上海,每十个人的死亡,其中三个人就死于癌症,<span style="color: black;">况且</span>这个数据在<span style="color: black;">持续</span><span style="color: black;">提升</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">癌症<span style="color: black;">好似</span>离<span style="color: black;">咱们</span>越来越近,<span style="color: black;">咱们</span>的<span style="color: black;">伴侣</span>,<span style="color: black;">咱们</span>的亲戚,<span style="color: black;">咱们</span>的<span style="color: black;">伴侣</span>的<span style="color: black;">伴侣</span>,总归会有人得癌症。越来越高的癌症<span style="color: black;">出现</span>率,正越来越引起<span style="color: black;">大众</span>的关注。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz/Jo4d3t8GbiasYF8BSUDJkJ2rKMpxRxm40O50W65jSvxial2OWtTV6WH73G7AaakQ3WTXX2lNnr5fzIJLS8eCicGQg/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">为何</span><span style="color: black;">此刻</span>癌症会如此高发?其<span style="color: black;">基本</span><span style="color: black;">原由</span>是什么?<span style="color: black;">非常多</span>人都把这归因于空气、水、食品的污染。这的确是非常非常<span style="color: black;">要紧</span>的<span style="color: black;">原由</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">但事实上,在世界上,有<span style="color: black;">非常多</span>比中国环境好<span style="color: black;">非常多</span>的国家,<span style="color: black;">例如</span>澳大利亚,新西兰,丹麦、挪威、美国、英国、法国,它们的癌症<span style="color: black;">出现</span>率是在<span style="color: black;">全世界</span>排在前十位。<span style="color: black;">非常多</span>人疑问,<strong style="color: blue;"><span style="color: black;">她们</span>空气这么好、环境这么好,<span style="color: black;">为何</span>癌症发病率还比中国多<span style="color: black;">非常多</span>呢?</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz/Jo4d3t8GbiasYF8BSUDJkJ2rKMpxRxm40etiatKbkr0FSdovWaKkOHOuRczfsnr7ia5jbhHcsxQepwG21ybPyXq2A/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">咱们</span>来看一个公式,从这个公式<span style="color: black;">能够</span>看出癌症<span style="color: black;">出现</span>的概率。一个人癌症<span style="color: black;">出现</span>有多大概率,<span style="color: black;">首要</span>是分裂次数,活得越长,当然分裂的次数就越多了。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">第二个是免疫细胞清除能力,这种清除能力是分母。在<span style="color: black;">非常多</span>时候,人老了,免疫细胞清除异型细胞越来越少,<span style="color: black;">便是</span>他清除能力少,当然癌症<span style="color: black;">出现</span>率就高,<span style="color: black;">因此</span><strong style="color: blue;">癌症<span style="color: black;">出现</span>最<span style="color: black;">基本</span>的<span style="color: black;">原由</span>是老龄化</strong>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">反过<span style="color: black;">来讲</span>,<span style="color: black;">咱们</span>看到澳大利亚、新西兰这些发达国家的寿命都比<span style="color: black;">咱们</span>长,<span style="color: black;">因此</span>寿命长才是癌症<span style="color: black;">出现</span>最<span style="color: black;">要紧</span>的<span style="color: black;">原由</span>。好多人说,我要移民到国外去了,到澳大利亚去了,<span style="color: black;">实质</span>上在澳大利亚癌症<span style="color: black;">出现</span>率比<span style="color: black;">咱们</span>中国还高。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz/Jo4d3t8GbiasYF8BSUDJkJ2rKMpxRxm40ZLu2HUo7kTkE4mSEDiciaGV4DwmuSZGht4thMTNf1aKoG55qho9kVQaw/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">在中国,癌症<span style="color: black;">出现</span>率最高的城市<span style="color: black;">便是</span>上海。<span style="color: black;">为何</span>呢?<span style="color: black;">由于</span>上海是全中国寿命最长的城市,和瑞士差不多。上海平均预期寿命:女的86岁,男的82岁,这<span style="color: black;">显著</span>超过世界上平均水平。<span style="color: black;">因此</span>癌症的<span style="color: black;">出现</span>率<span style="color: black;">亦</span>高。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">因此</span><span style="color: black;">大众</span><span style="color: black;">无</span>什么好害怕的,<span style="color: black;">由于</span>你老了,癌症的<span style="color: black;">出现</span>率就会<span style="color: black;">加强</span>。虽然环境污染、家族史都是癌症<span style="color: black;">出现</span>的<span style="color: black;">要紧</span><span style="color: black;">原由</span>,但最<span style="color: black;">基本</span>的<span style="color: black;">原由</span>是老龄化,这个公式非常清晰地告诉了<span style="color: black;">咱们</span>这一点。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">当癌症<span style="color: black;">出现</span>后,去做基因检测的时候,<span style="color: black;">能够</span>看到有<span style="color: black;">非常多</span><span style="color: black;">非常多</span>的突变。不同的肿瘤有不同的突变率,像最右边的黑色素瘤,它的突变有将近十万个突变。那这么多突变,既使白血病是相对最少的,他突变<span style="color: black;">实质</span>数量<span style="color: black;">亦</span>非常多。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">在这么多突变中,<span style="color: black;">咱们</span>要找到癌症<span style="color: black;">出现</span>的<span style="color: black;">基本</span><span style="color: black;">原由</span>,<span style="color: black;">才可</span>下手去治疗。<span style="color: black;">非常多</span><span style="color: black;">专家</span><span style="color: black;">或</span>是<span style="color: black;">大夫</span>,<span style="color: black;">持续</span>去<span style="color: black;">科研</span>癌症是怎么<span style="color: black;">出现</span>的,试图找到它<span style="color: black;">基本</span><span style="color: black;">原由</span>,最后一举把它治好。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">实质</span>上,最早的时候,<span style="color: black;">咱们</span>认为,癌症就像一个肿块,动手术把肿块切掉。当然切得越大,复发的概率就越低。但<span style="color: black;">实质</span>上,<strong style="color: blue;">癌症是一个全身性的<span style="color: black;">疾患</span></strong>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">一<span style="color: black;">起始</span>是局部的表现,一旦转移,他不<span style="color: black;">是由于</span>原点出发慢慢转移出去,而是风车<span style="color: black;">同样</span>慢慢扩散。一旦转移,就会转移到很远的<span style="color: black;">地区</span>去。<span style="color: black;">因此呢</span>,<span style="color: black;">经过</span>手术切得越大<span style="color: black;">亦</span><span style="color: black;">无</span>什么用处,它要复发的还是会复发。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz/Jo4d3t8GbiasYF8BSUDJkJ2rKMpxRxm40hiahPVVibDQ3Mr7VCkL6h1ib2nWTmQp9BckMTy7ricibZaaJUwcgCs3rovw/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">后来随着时间的推移,<span style="color: black;">非常多</span><span style="color: black;">专家</span>认为癌症<span style="color: black;">便是</span>长得快,<strong style="color: blue;">癌症细胞区别于正常细胞的特点<span style="color: black;">便是</span>长得太快了,<span style="color: black;">因此</span>把长得快的细胞杀掉,这<span style="color: black;">便是</span>放化疗的<span style="color: black;">发掘</span>。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">放化疗是第二次世界大战后发明的。用放化疗的手段把长得快的细胞杀掉,但其他正常组织<span style="color: black;">亦</span>有长得快的,<span style="color: black;">尤其</span>是头发、胃肠道粘膜细胞,<span style="color: black;">因此</span>放化疗的时候,<span style="color: black;">咱们</span>的头发<span style="color: black;">亦</span>会掉下来,胃肠道功能<span style="color: black;">亦</span>会<span style="color: black;">欠好</span>,这<span style="color: black;">便是</span>放化疗病人表现出来的副<span style="color: black;">功效</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">但其实<span style="color: black;">针对</span>癌症细胞<span style="color: black;">来讲</span>,<span style="color: black;">亦</span>有长得慢的,长得快的给你放化疗杀死了,那长得慢的就杀不死。后来医学界去<span style="color: black;">更加多</span>地<span style="color: black;">科研</span>机理。癌症<span style="color: black;">出现</span>是<span style="color: black;">怎么样</span>的,<span style="color: black;">期盼</span>从信号传导等<span style="color: black;">各样</span>各样的方面都把它搞清楚。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">癌症这么多突变,越搞越<span style="color: black;">繁杂</span>。癌细胞像一个网络<span style="color: black;">同样</span>,越<span style="color: black;">科研</span>越觉得<span style="color: black;">好似</span><span style="color: black;">咱们</span>这辈子是治<span style="color: black;">欠好</span>癌症了,<span style="color: black;">或</span>下<span style="color: black;">一生</span><span style="color: black;">亦</span>治<span style="color: black;">欠好</span>了。<span style="color: black;">由于</span>太<span style="color: black;">繁杂</span>了,<span style="color: black;">科研</span>癌症的科学论文越来越多,但似乎都很难能找到肿瘤治疗的一个好的办法。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">近期</span>几年,科学界对癌症治疗有一个新的认识,能否重新审视癌症,用一个简单<span style="color: black;">有些</span>的办法。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz/Jo4d3t8GbiasYF8BSUDJkJ2rKMpxRxm4020rFxoFjdSV6ovuIpQ7csKUgucxtujibMZLltSo0hZReI4jQzs6iaU3Q/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">这个简单办法<span style="color: black;">便是</span>,<span style="color: black;">咱们</span>只要<span style="color: black;">晓得</span>癌症细胞和正常细胞有什么差别,而这个差别点,是免疫细胞能够认识它的,<span style="color: black;">倘若</span>免疫细胞能够对差别点能发起攻击的话,<span style="color: black;">亦</span>能被<span style="color: black;">咱们</span><span style="color: black;">海量</span>找到,<span style="color: black;">或</span><span style="color: black;">海量</span>的扩增后放到<span style="color: black;">身体</span>去,就有可能治愈癌症。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">因此呢</span>,<span style="color: black;">咱们</span><span style="color: black;">无</span>必要像<span style="color: black;">科研</span>机理<span style="color: black;">科研</span><span style="color: black;">那样</span>清楚,<span style="color: black;">咱们</span>只<span style="color: black;">必须</span><span style="color: black;">晓得</span>它的差别。<span style="color: black;">实质</span>上找到差别是个比较简单的<span style="color: black;">办法</span>,<span style="color: black;">由于</span>基因检测很容易看到它的差别。<strong style="color: blue;">一旦找到了差别,只要让细胞去发起攻击,免疫细胞就有可能治愈癌症。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">那样</span>,<span style="color: black;">日前</span>世界上的免疫疗法<span style="color: black;">发展</span>到什么程度了呢?2013年,《科学》杂志将癌症的免疫治疗在全世界所有科学突破<span style="color: black;">发掘</span>的排名里,排<span style="color: black;">第1</span>名。2015和2016年的美国临床肿瘤年会上(世界上所有顶级的<span style="color: black;">专家</span>和<span style="color: black;">大夫</span>,都会去参加这个年会)免疫治疗<span style="color: black;">作为</span>最大的亮点。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">实质</span>上,一百<span style="color: black;">数年</span>前人们就<span style="color: black;">已然</span>想过免疫疗法的原理了。<span style="color: black;">由于</span>人体的免疫细胞是天然能够识别正常细胞和肿瘤细胞的,<span style="color: black;">因此</span>在很<span style="color: black;">初期</span>,<span style="color: black;">咱们</span>就用这个<span style="color: black;">办法</span>来做了。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">这种非特异性的<span style="color: black;">加强</span>机体免疫,<span style="color: black;">期盼</span><strong style="color: blue;"><span style="color: black;">经过</span>机体免疫的<span style="color: black;">加强</span>来治愈癌症,虽然讲的非常好,但<span style="color: black;">实质</span>效果非常差</strong>。<span style="color: black;">非常多</span>时候,<span style="color: black;">咱们</span>都<span style="color: black;">期盼</span>它有非常好的临床疗效,但事实上做不出来。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">直到2010年过后,<span style="color: black;">非常多</span>特异性的免疫治疗,<span style="color: black;">创立</span>了非常<span style="color: black;">精细</span>的杀肿瘤的免疫<span style="color: black;">办法</span>,看到<span style="color: black;">非常多</span>的临床肿瘤消退,<span style="color: black;">乃至</span>肿瘤得到治愈。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">因此呢</span>,<span style="color: black;">咱们</span>把非特异性的免疫说成是民兵,尽管民兵人<span style="color: black;">非常多</span>,但并<span style="color: black;">不可</span>使有<span style="color: black;">海量</span>的肿瘤得到治疗,而特异性的免疫是一个特种兵,它能够更好底<span style="color: black;">解决</span>堡垒,针对很大的肿瘤组织进行治疗并产生疗效。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">进一步<span style="color: black;">来讲</span>,非特异性的免疫,对非常小的肿瘤残灶,就似是肿瘤<span style="color: black;">经过</span>手术切除了,可能还剩一点残留灶,或许是有<span style="color: black;">帮忙</span>的,对抗复发是有<span style="color: black;">帮忙</span>的,<span style="color: black;">然则</span>对晚期肿瘤,是几乎<span style="color: black;">无</span>什么效果的。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz/Jo4d3t8GbiasYF8BSUDJkJ2rKMpxRxm40nviaXrKXfXQAffhyHdXevlQtFGLAlDoFicjXs4m41ibzWc7QHROZZ85IQ/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">讲到免疫治疗,<span style="color: black;">大众</span>会想到5月份(2016年)的时候,一个<span style="color: black;">导致</span>广泛关注的魏则西事件。<span style="color: black;">实质</span>上,<strong style="color: blue;">魏则西事件</strong>中,<span style="color: black;">便是</span>用一个非特异性免疫治疗晚期癌症的事例。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">咱们</span><span style="color: black;">能够</span>看到,<span style="color: black;">针对</span>晚期癌症,肿瘤细胞这么多的<span style="color: black;">状况</span>下,只是<span style="color: black;">经过</span><span style="color: black;">加强</span>非特异性来<span style="color: black;">加强</span>免疫,是不可能使病人得到治愈的。<span style="color: black;">然则</span>,当然<span style="color: black;">咱们</span><span style="color: black;">亦</span><span style="color: black;">不可</span>说是这个免疫疗法而<span style="color: black;">引起</span>病人的死亡。<span style="color: black;">由于</span>魏则西,在上海、北京、广州,所有的大医院都去看过了。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">大夫</span>都告诉他,你不要再治疗了,治疗了<span style="color: black;">亦</span><span style="color: black;">无</span>什么效果,<span style="color: black;">然则</span>家长还是<span style="color: black;">期盼</span>,哪怕<span style="color: black;">仅有</span>一点<span style="color: black;">期盼</span>,一点机会,都还是<span style="color: black;">期盼</span>能够进行治疗。<span style="color: black;">因此</span>他就跑到医院去做免疫治疗,<span style="color: black;">然则</span>非特异性免疫。我刚才讲过,它是能够<span style="color: black;">加强</span>生活质量的。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">魏则西用了免疫治疗后,他<span style="color: black;">火速</span>感觉到自己有力气了,各方面<span style="color: black;">状况</span>都在改善。<span style="color: black;">然则</span>,在<span style="color: black;">非常多</span>肿瘤的<span style="color: black;">状况</span>下,并<span style="color: black;">不可</span>够把肿瘤完全治好。他活了17个月。差不多病情的这种病人,在美国做临床<span style="color: black;">实验</span>,<span style="color: black;">倘若</span>用靶向<span style="color: black;">药品</span>做治疗,大概寿命是12个月。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">能够</span>看到,免疫治疗并<span style="color: black;">无</span>很<span style="color: black;">知道</span>地把他治好,但<span style="color: black;">亦</span><span style="color: black;">不可</span>说是免疫治疗把他治死了,只能说,<strong style="color: blue;">他是肿瘤发展到<span style="color: black;">必定</span>程度最后<span style="color: black;">引起</span>了<span style="color: black;">全部</span>死亡</strong>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">这般</span>一个事件,<span style="color: black;">为何</span><span style="color: black;">火速</span><span style="color: black;">导致</span>这么大的公众效应?<span style="color: black;">非常多</span>老<span style="color: black;">大众</span>都会关注,<span style="color: black;">晓得</span>这一件事情呢?是<span style="color: black;">由于</span>非特异性的免疫被过度<span style="color: black;">商场</span>化,被过度包装宣传。本来非特异性免疫疗法对微小肿瘤<span style="color: black;">或</span>和其它治疗<span style="color: black;">一块</span>可能会有<span style="color: black;">有些</span>疗效,但其实他并<span style="color: black;">不可</span>使大的肿瘤消退。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">当被过度<span style="color: black;">商场</span>化的时候,<span style="color: black;">导致</span>老<span style="color: black;">大众</span>很大的反感。</span></strong><span style="color: black;">还有一个很<span style="color: black;">要紧</span>的<span style="color: black;">原由</span>,他的承包科室、百度排名,这些<span style="color: black;">原因</span>合在<span style="color: black;">一块</span>,就变成一个非常大的事情。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">然则</span>,魏则西事件后并不是所有都是反面的,<span style="color: black;">亦</span>有正面的,它让<span style="color: black;">大众</span><span style="color: black;">更加多</span><span style="color: black;">认识</span>到免疫治疗。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">咱们</span>重点来说特异性免疫治疗,从刚才那个图<span style="color: black;">能够</span>看得非常清楚,<span style="color: black;">已然</span>越来越<span style="color: black;">导致</span>全世界的关注,全世界<span style="color: black;">亦</span>越来越多把肿瘤治疗的<span style="color: black;">期盼</span><span style="color: black;">拜托</span>在免疫治疗上,所<span style="color: black;">以避免</span>疫治疗是不可阻挡的,<span style="color: black;">况且</span>会越来越加速发展。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz/Jo4d3t8GbiasYF8BSUDJkJ2rKMpxRxm40OsGjGmtWk1ysZcNTtmUwCnbqbJicdVibcNUkNrB9ybNXw3GGDTGYPA3w/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">特异性的免疫</span></strong><span style="color: black;">,说到底就<span style="color: black;">便是</span>一个免疫T细胞,这个T细胞是在特异性免疫中起到一个<span style="color: black;">重要</span>的<span style="color: black;">功效</span>,<span style="color: black;">那样</span>这个T细胞怎么认识肿瘤细胞的?</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">咱们</span>把T细胞比成一个汽车,汽车<span style="color: black;">首要</span>要发动机去发动,发动过后<span style="color: black;">晓得</span>要去攻击什么<span style="color: black;">目的</span>,后面要加油门,最后刹车要松开,这是<span style="color: black;">咱们</span>开汽车的一个过程。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">T细胞是免疫细胞最<span style="color: black;">要紧</span>的一个细胞,<span style="color: black;">因此</span>发动,<span style="color: black;">咱们</span>的CAR-T、TCR-T,<span style="color: black;">亦</span>是加油门的CAR-T的一个部分,还有一个松刹车,那个免疫治疗的一个<span style="color: black;">要紧</span>方向,免疫在肿瘤微环境中受到很大的<span style="color: black;">控制</span>,<span style="color: black;">非常多</span>免疫细胞进去以后,被刹车刹住,它起不了效果,<span style="color: black;">因此</span>要把刹车松开,它才会有更好的效果。这几个方向高速的发展,使<span style="color: black;">咱们</span>对免疫治疗越来越明白。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">咱们</span>讲两个例证。国外的,<span style="color: black;">能够</span>看到这个Emily,她是用CAR-T来做治疗的。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">在所有治疗都<span style="color: black;">无</span>效果的时候,这种急性B淋巴细胞白血病,<span style="color: black;">包含</span>骨髓移植治疗都<span style="color: black;">无</span>效果了,用CAR-T来做治疗的,有90%到94%的完全缓解率。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">亦</span><span style="color: black;">便是</span>说,在所有常规<span style="color: black;">办法</span>都<span style="color: black;">不可</span>治疗的时候,还有90%到94%的肿瘤完全消退。还有一个例子<span style="color: black;">便是</span>美国的前总统卡特,这个可能<span style="color: black;">非常多</span>人都听过,他在去年8月份宣布他是黑色素瘤脑转移、肝脏转移。<span style="color: black;">由于</span>黑色素瘤是一个非常恶性的<span style="color: black;">疾患</span>,<span style="color: black;">因此</span>当初用<span style="color: black;">这般</span>常规治疗,他可能活<span style="color: black;">不外</span>半年<span style="color: black;">。</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz/Jo4d3t8GbiasYF8BSUDJkJ2rKMpxRxm40iaJnXQXD0nAMRp56xc9C7kRHO8w25kz8ThXXhyePticsp7tl2uC2sB6w/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">然则</span>他当时<span style="color: black;">晓得</span>自己<span style="color: black;">已然</span>90岁了,<span style="color: black;">晓得</span>自己得这种病的时候,他非常<span style="color: black;">阳光</span>,告诉<span style="color: black;">大众</span>我要用世界上最先进的免疫治疗要进行治疗了。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">后来,他<span style="color: black;">便是</span>用这个免疫治疗加放疗。<span style="color: black;">火速</span>的到12月份,他肿瘤完全<span style="color: black;">无</span>了,到今年3月份,他宣布我<span style="color: black;">已然</span>治愈了,<span style="color: black;">再也不</span>接受任何治疗了。<span style="color: black;">因此</span><span style="color: black;">能够</span>看到这是特异性免疫治疗的两个例证。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">刚才所说的卡特<span style="color: black;">运用</span>的疗法,<span style="color: black;">便是</span>免疫<span style="color: black;">检测</span>点抗体的<span style="color: black;">办法</span>,<span style="color: black;">亦</span>是刚才说的松刹车这个<span style="color: black;">办法</span>。这个<span style="color: black;">办法</span><span style="color: black;">此刻</span>在世界上所有肿瘤基本都在做临床<span style="color: black;">实验</span>,<span style="color: black;">此刻</span>大概有效率在20%到30%<span style="color: black;">上下</span>。<span style="color: black;">然则</span>这个20%到30%对晚期实体瘤<span style="color: black;">来讲</span>,<span style="color: black;">实质</span>上它<span style="color: black;">已然</span>是非常有效果了。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">况且</span><strong style="color: blue;">它更大的特点是,一旦有效果,它复发几率比较低</strong>,它不像放化疗,放化疗做了以后肿瘤<span style="color: black;">火速</span><span style="color: black;">无</span>了,过一段时间又复发了,那免疫治疗呢,它一旦产生疗效过后,它的复发率很低。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">但这两种治疗<span style="color: black;">办法</span>的价格。CAR-T在美国预计30到50万美金一个疗程,那这个PD-1抗体,一个抗体一年15万美金,<span style="color: black;">那样</span>两个抗体30万美金,以后可能有<span style="color: black;">更加多</span>的抗体可能更贵。<span style="color: black;">因此</span><span style="color: black;">这般</span>的<span style="color: black;">状况</span>下,以中国人的平均收入来看,<span style="color: black;">好似</span>很难用得起。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">因此呢</span><span style="color: black;">咱们</span>提出来一个白泽计划,<strong style="color: blue;"><span style="color: black;">目的</span>是在<span style="color: black;">将来</span>十年,<span style="color: black;">期盼</span>60%的晚期肿瘤能够消退,60%的中国人能够用得起这个治疗的<span style="color: black;">办法</span>。</strong><span style="color: black;">这般</span>的话,才会使<span style="color: black;">非常多</span>中国人真正得到获益。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">什么叫白泽计划,<span style="color: black;">为何</span>叫白泽计划?白泽<span style="color: black;">实质</span>上是一个昆仑山上的一个神兽,它<span style="color: black;">晓得</span>所有妖怪,鬼怪的名字,形状和驱除方术。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">这和<span style="color: black;">咱们</span>免疫细胞非常相近,<span style="color: black;">咱们</span>免疫细胞能够<span style="color: black;">晓得</span>机<span style="color: black;">身体</span>所有的肿瘤细胞,异型细胞,衰老细胞,<span style="color: black;">亦</span>能够知晓怎么能够驱除,能够把它杀死。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">况且</span>一个<span style="color: black;">原由</span>,白泽是一个吉祥之兽,是一个神兽,<span style="color: black;">因此</span><span style="color: black;">咱们</span><span style="color: black;">期盼</span>吉祥的神兽给<span style="color: black;">更加多</span>的病人来<span style="color: black;">期盼</span>、吉祥和<span style="color: black;">安全</span>,这<span style="color: black;">便是</span><span style="color: black;">咱们</span>的初衷。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">白泽计划一个很<span style="color: black;">要紧</span>的核心,<span style="color: black;">便是</span>怎么能够实现疗效达到60%肿瘤消褪,价格又要便宜。<span style="color: black;">咱们</span>很明白一点,肿瘤是一个全身性<span style="color: black;">疾患</span>,局部表现。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">对一个肿瘤<span style="color: black;">来讲</span>,它<span style="color: black;">实质</span>上并不是均质的免疫<span style="color: black;">控制</span>,均质的免疫<span style="color: black;">反常</span>,在肿瘤组织里面免疫<span style="color: black;">控制</span>是非常非常高的。而在全身呢,<span style="color: black;">亦</span>有一点免疫<span style="color: black;">控制</span>,但不是很强。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">因此呢</span>,白泽计划很<span style="color: black;">要紧</span>的是,利用免疫细胞天然的特性,<span style="color: black;">经过</span>它的趋化性到肿瘤位置去,<span style="color: black;">火速</span>的把肿瘤里的免疫调上来,把免疫<span style="color: black;">控制</span>进行解除。<span style="color: black;">期盼</span>肿瘤局部<span style="color: black;">叫作</span>为免疫的战场,免疫占主导,<span style="color: black;">这般</span>的话,肿瘤细胞就能杀死了。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">由于</span>肿瘤组织可能在全身<span style="color: black;">非常多</span>部位,<span style="color: black;">经过</span>免疫细胞自动去寻找,寻找到它的部位,<span style="color: black;">而后</span>把它的免疫<span style="color: black;">控制</span>调节起来,而不是把全身<span style="color: black;">全部</span>免疫平衡破坏。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">国际上<span style="color: black;">此刻</span>用免疫<span style="color: black;">检测</span>点抗体,<span style="color: black;">特别有</span>可能<span style="color: black;">便是</span>说<span style="color: black;">引起</span>全身的免疫过强,最后产生<span style="color: black;">自己</span>免疫性<span style="color: black;">疾患</span>,<span style="color: black;">例如</span>间质性肺炎<span style="color: black;">这般</span>的副<span style="color: black;">功效</span><span style="color: black;">亦</span>会<span style="color: black;">引起</span>死亡,而这个白泽计划则不会,<span style="color: black;">咱们</span>全身是<span style="color: black;">处在</span>一个免疫平衡,只是把局部的肿瘤组织<span style="color: black;">作为</span>免疫的战场,<span style="color: black;">期盼</span>它能够更加有效果。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">在这个战场,免疫细胞越活得好,那肿瘤就越容易被杀死。越来越多的肿瘤能够得到治愈,<span style="color: black;">那样</span><span style="color: black;">咱们</span><span style="color: black;">由于</span>不<span style="color: black;">必须</span>大规模的工业化,只要<span style="color: black;">经过</span>免疫细胞来实现,<span style="color: black;">因此</span>价格就<span style="color: black;">能够</span>非常便宜。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">举一个例子,这是一个肝癌病人。他做了手术过后三个月,满肝都是肿瘤,<span style="color: black;">能够</span>看到这个红圆圈里面的,黑的<span style="color: black;">地区</span>都是肿瘤。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">在白泽计划里面,进行一个疗程的治疗,<span style="color: black;">咱们</span><span style="color: black;">能够</span>看到下面两张肿瘤完全<span style="color: black;">无</span>了。所<span style="color: black;">以避免</span>疫治疗<span style="color: black;">再也不</span>像以前那样是非常慢的,<span style="color: black;">好似</span>慢慢<span style="color: black;">护理</span>,他可能是一个非常快速的,能够使肿瘤<span style="color: black;">火速</span>的消退,这么大的肿瘤,这么多的肿瘤,<span style="color: black;">火速</span>在三个月不到的时间,肿瘤完全<span style="color: black;">无</span>了。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">因此</span>这计划,可能会带来一个突破性的<span style="color: black;">发展</span>。为了把这个白泽计划做的更加好,<span style="color: black;">咱们</span>申请了<span style="color: black;">非常多</span>专利,其中12项细胞治疗的<span style="color: black;">重要</span>专利,被国家专利局认为是<span style="color: black;">触及</span>到国家重大利益,<span style="color: black;">必须</span>保密审查的,<span style="color: black;">因此</span><span style="color: black;">咱们</span>的技术<span style="color: black;">必须</span><span style="color: black;">持续</span>的突破。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="data:image/svg+xml,%3C%3Fxml version=1.0 encoding=UTF-8%3F%3E%3Csvg width=1px height=1px viewBox=0 0 1 1 version=1.1 xmlns=http://www.w3.org/2000/svg xmlns:xlink=http://www.w3.org/1999/xlink%3E%3Ctitle%3E%3C/title%3E%3Cg stroke=none stroke-width=1 fill=none fill-rule=evenodd fill-opacity=0%3E%3Cg transform=translate(-249.000000, -126.000000) fill=%23FFFFFF%3E%3Crect x=249 y=126 width=1 height=1%3E%3C/rect%3E%3C/g%3E%3C/g%3E%3C/svg%3E" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">针对</span>免疫治疗<span style="color: black;">来讲</span>,<span style="color: black;">咱们</span>很早在《黄帝内经》上<span style="color: black;">亦</span>提过这个:正气存内,邪不可干。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">什么意思呢?是说全身<span style="color: black;">状况</span>非常好,你的免疫非常好,<span style="color: black;">实质</span>上是不会得肿瘤的,<span style="color: black;">这般</span>一个理念,<span style="color: black;">亦</span>是在中医文化里面<span style="color: black;">非常多</span>的得到讲解。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">那样</span><span style="color: black;">针对</span>一个人<span style="color: black;">来讲</span>,他可能确确实实免疫非常好,可能不会得肿瘤,<span style="color: black;">然则</span><span style="color: black;">倘若</span>肿瘤<span style="color: black;">已然</span>非常多了,单靠<span style="color: black;">加强</span><span style="color: black;">基本</span>的免疫,它是不足够的,是不足以让这个肿瘤消退的。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">因此</span><span style="color: black;">倘若</span>说<span style="color: black;">咱们</span>老是想<span style="color: black;">咱们</span>免疫功能稍微高一点,就<span style="color: black;">期盼</span>能够把肿瘤治好,这是不现实的,他还是<span style="color: black;">必须</span>像刚才讲的要特异性免疫,要这种特种兵,他<span style="color: black;">才可</span>更有机会把非常大的肿瘤得到治疗,逐步消退。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">医学是在<span style="color: black;">持续</span>的发展的,<span style="color: black;">仅有</span><span style="color: black;">持续</span>的发展,<span style="color: black;">持续</span>地<span style="color: black;">开发</span>新的技术,才有可能真正使肿瘤得到治愈。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">因此</span><span style="color: black;">咱们</span>再总结一下,<span style="color: black;">咱们</span>什么<span style="color: black;">处理</span>之道,<span style="color: black;">咱们</span>的白泽计划是干什么,<span style="color: black;">咱们</span>的白泽计划<span style="color: black;">便是</span><span style="color: black;">按照</span>这个病人差异性的免疫<span style="color: black;">控制</span>的<span style="color: black;">状况</span>,病人全身免疫低下一点,但肿瘤局部免疫是非常非常严重被<span style="color: black;">控制</span>的状态。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="data:image/svg+xml,%3C%3Fxml version=1.0 encoding=UTF-8%3F%3E%3Csvg width=1px height=1px viewBox=0 0 1 1 version=1.1 xmlns=http://www.w3.org/2000/svg xmlns:xlink=http://www.w3.org/1999/xlink%3E%3Ctitle%3E%3C/title%3E%3Cg stroke=none stroke-width=1 fill=none fill-rule=evenodd fill-opacity=0%3E%3Cg transform=translate(-249.000000, -126.000000) fill=%23FFFFFF%3E%3Crect x=249 y=126 width=1 height=1%3E%3C/rect%3E%3C/g%3E%3C/g%3E%3C/svg%3E" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">咱们</span><span style="color: black;">按照</span>这个差异性差别,能够利用免疫细胞天然的趋向肿瘤的特征,能够在肿瘤局部变成非常强的免疫的能力,变成免疫的战场,把免疫的<span style="color: black;">控制</span>进行解除掉,再<span style="color: black;">便是</span>会使局部肿瘤得到很好的治疗,<span style="color: black;">非常多</span>的局部肿瘤<span style="color: black;">火速</span>的消退。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">同期</span>释放出来免疫细胞,在全身做巡逻,变成一个记忆型的细胞,<span style="color: black;">这般</span>的话,它把全身其他残留的肿瘤<span style="color: black;">亦</span>得到治愈,这<span style="color: black;">便是</span><span style="color: black;">咱们</span>的<span style="color: black;">处理</span>之道。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">谢谢<span style="color: black;">大众</span>的聆听。</span></p>
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你的见解独到,让我受益匪浅,期待更多交流。 感谢楼主的分享!我学到了很多。
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