神仙级生信肿瘤数据库运用指南，你不会还不晓得吧？
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">相信各位小伙伴们在听过我的生信导学课后，都<span style="color: black;">晓得</span>了生信的核心乃是数据，<span style="color: black;">无</span>数据就好比巧妇难为<span style="color: black;">没</span>米之炊~</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-e013141a0db7eccaf8a24cae963bb1c2_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">尤其是针对分析肿瘤<span style="color: black;">行业</span>的小伙伴们，<span style="color: black;">不但</span><span style="color: black;">必须</span>丰富的数据来支持自己的各项分析，<span style="color: black;">况且</span>还<span style="color: black;">必须</span>“独特”的数据来彰显自己分析的与众不同。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">那样</span>下面<span style="color: black;">博主</span>就给<span style="color: black;">大众</span>带来一个<span style="color: black;">包括</span>人类多个癌症细胞系（即<span style="color: black;">包括</span>基因表达数据、染色体拷贝数据和大规模平行测序数据）的神仙级数据库——CCLE数据库。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">CCLE数据库支持操作者在线<span style="color: black;">查找</span>基因在肿瘤细胞系的表达和突变<span style="color: black;">状况</span>，<span style="color: black;">经过</span>对该数据库的灵活<span style="color: black;">运用</span><span style="color: black;">能够</span>让你的生信分析从<span style="color: black;">更加多</span>维度解释肿瘤中基因表达谱的变化，并且<span style="color: black;">不但</span>是数据丰富，就连其自带的可视化操作<span style="color: black;">工具</span>都<span style="color: black;">能够</span>做到，只<span style="color: black;">必须</span>鼠标简单操作<span style="color: black;">就可</span>分分钟可视化<span style="color: black;">发布</span>级图表。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">那样</span>下面就让<span style="color: black;">咱们</span>进行CCLE数据库的<span style="color: black;">仔细</span><span style="color: black;">诠释</span>吧~</p>
<h2 style="color: black; text-align: left; margin-bottom: 10px;">CCLE数据库简介</h2>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">CCLE数据库全<span style="color: black;">叫作</span>——Cancer Cell Line Encyclopedia即癌症细胞系百科全书，其数据库内<span style="color: black;">包括</span>对上千种癌细胞系的多组学图谱深度解析且于2019年进行更新后，<span style="color: black;">更加是</span>新增了1000多个细胞系的遗传突变、RNA剪接DNA甲基化、组蛋白修饰等<span style="color: black;">关联</span>信息。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">不但</span>数据方面<span style="color: black;">非常</span>丰富，就连可视化方面都做得都与前者旗鼓相当，其基因表达数据能可视化为条形图、基因甲基化<span style="color: black;">能够</span><span style="color: black;">经过</span>气泡图来可视化<span style="color: black;">况且</span>支持在不同细胞系中进行可视化分析，更为<span style="color: black;">要紧</span>的是支持单个细胞系突变数据的在线查看和下载，满足你的一切生信需求，既<span style="color: black;">能够</span>当作数据的丰富<span style="color: black;">源自</span>，又<span style="color: black;">能够</span>分分钟可视化出<span style="color: black;">发布</span>级<span style="color: black;">照片</span>。是你肿瘤分析中的不二<span style="color: black;">选取</span>。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic2.zhimg.com/80/v2-47148c49092c1ccb8aa33eb7b7a0b7a9_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
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<h2 style="color: black; text-align: left; margin-bottom: 10px;">CCLE数据库页面介绍</h2>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">登录CCLE数据库，点击导航栏中的“about”<span style="color: black;">能够</span>进入about页面，此页面展示的是CCLE数据库的基本数据信息，<span style="color: black;">包含</span>数据数目及种类等等。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-e79aab3fc6309e1d3a27cdca55b96402_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">点击导航栏“Data”可进入Data页面之后<span style="color: black;">能够</span>查看和下载所要搜索的细胞系或基因组的<span style="color: black;">关联</span>数据，<span style="color: black;">这儿</span>的数据会分为三个模块（<span style="color: black;">博主</span>提示：<span style="color: black;">然则</span><span style="color: black;">必要</span>登录<span style="color: black;">网</span>才<span style="color: black;">能够</span>查看和下载哦~）</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic2.zhimg.com/80/v2-15fdb1881d518c3dde3dd49f36d91ff5_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">博主</span>划重点~~~，<span style="color: black;">倘若</span>你的分析中想做耐药实验，想对某个靶点进行<span style="color: black;">药品</span>处理，<span style="color: black;">此时</span>候你<span style="color: black;">亦</span><span style="color: black;">能够</span><span style="color: black;">运用</span>这个数据库，只<span style="color: black;">必须</span>在某个细胞系中，<span style="color: black;">查找</span>其IC50值，<span style="color: black;">就可</span><span style="color: black;">做为</span><span style="color: black;">药品</span>浓度参考（药理学的小伙伴们都惊呆了~）</p>
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<h2 style="color: black; text-align: left; margin-bottom: 10px;">CCLE数据库核心功能详解（可视化）</h2>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">俗话说的好“一图胜千言”，优秀的数据结果，<span style="color: black;">倘若</span><span style="color: black;">无</span>一个优秀的可视化结果岂不是一大憾事！<span style="color: black;">那样</span>接下来就带<span style="color: black;">大众</span>大致<span style="color: black;">认识</span>一下CCLE数据库可视化<span style="color: black;">过程</span>，<span style="color: black;">仔细</span>的学习请参见解螺旋精品单元课哦~</p>
<h3 style="color: black; text-align: left; margin-bottom: 10px;">绘制基因表达谱</h3>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在检索栏输入基因或细胞系名<span style="color: black;">叫作</span>，以“TP53”为例，点击“Search”，待页面刷新后，可视化结果即立刻呈现（不是吧~居然这么简单）。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-99132d69f5c3cfde906803fc3b95515e_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">敲黑板划重点啦~<span style="color: black;">不但</span>有箱线图，散点图<span style="color: black;">亦</span><span style="color: black;">能够</span><span style="color: black;">经过</span>鼠标点点点的操作进行即时可视化哦~</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-97f219c07d0b53e9334f2eb9168f589e_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">此时</span>候可能有小伙伴会问了，<span style="color: black;">博主</span>，你说这么好的数据库，<span style="color: black;">为何</span>我在以前<span style="color: black;">无</span><span style="color: black;">重视</span>到呢，<span style="color: black;">是否</span>很少有人<span style="color: black;">运用</span>啊！</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">面对这类的提问，<span style="color: black;">博主</span>的回答<span style="color: black;">仅有</span>一个“NO~NO~NO”其实有<span style="color: black;">非常多</span><span style="color: black;">文案</span>都<span style="color: black;">运用</span>了这个数据库，只<span style="color: black;">不外</span>平时的你可能<span style="color: black;">无</span><span style="color: black;">重视</span>到罢了，下面这篇<span style="color: black;">文案</span>就用了CCLE数据库进行了部分可视化：</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic2.zhimg.com/80/v2-1b3146d6da72352e19ff7833085ae499_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">倘若</span>觉得影响因子<span style="color: black;">不足</span>高，<span style="color: black;">咱们</span><span style="color: black;">这儿</span>还有更高的哦~</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic1.zhimg.com/80/v2-ef05b4eb11eeef82d14a35567a4a4dd0_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">都看到<span style="color: black;">这儿</span>了，小伙伴们还有理由不去学习这个数据丰富+分分钟可视化<span style="color: black;">发布</span>级<span style="color: black;">照片</span>+高影响因子杂志“红人”的神仙级数据库吗？</p>
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