esc0rp 发表于 2024-8-10 18:16:04

歪打正着的药物（三）


    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">前边讲了两类无意中<span style="color: black;">发掘</span>的新药。<span style="color: black;">不外</span>，某些“</span><strong style="color: blue;"><span style="color: black;">新药</span></strong><span style="color: black;">”未必都新，有的是老药新用，在原有药理<span style="color: black;">功效</span>之外又<span style="color: black;">发掘</span>了还有其他活性。因而有些<span style="color: black;">药品</span>是跳槽跨界身兼数职的。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p26-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/18d0bf166e37455eb628ad7248c7d2a5~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=4FnIZ00OoB5X8ezlhdxwUoyMOVI%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;"><span style="color: black;">时来运转</span></span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;"><span style="color: black;">调节免疫</span></span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">甲氨喋呤</span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">这个20世纪50年代<span style="color: black;">研发</span>的<span style="color: black;">药品</span>，是</span><strong style="color: blue;"><span style="color: black;">抗叶酸类</span></strong><span style="color: black;">抗肿瘤药，用于急性白血病、乳腺癌、绒毛膜上皮癌等十几种癌症化疗。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/9b1e2f2da03f4adb80300e86a7937ebb~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=xW8mXFXg54DFCXJMLR6KzSHEJ%2F8%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">在<span style="color: black;">开发</span>初期，就<span style="color: black;">发掘</span>它既能<span style="color: black;">控制</span>癌细胞的增殖，<span style="color: black;">亦</span>能<span style="color: black;">控制</span>淋巴细胞的增殖，后者恰恰是治疗<span style="color: black;">自己</span>免疫性<span style="color: black;">疾患</span>的重要途径。<span style="color: black;">因此呢</span></span><strong style="color: blue;"><span style="color: black;">甲氨喋呤</span></strong><span style="color: black;">在1971年就被用于治疗与免疫系统<span style="color: black;">错乱</span><span style="color: black;">相关</span>的顽固性牛皮癣。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/898ac750e104455f96f44833eedd36dc~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=IvD4J3TlDocdWMzWiTcNNam1XfA%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">1988年，低剂量的</span><strong style="color: blue;"><span style="color: black;">甲氨喋呤</span></strong><span style="color: black;">正式用于治疗多种<span style="color: black;">自己</span>免疫性<span style="color: black;">疾患</span>，<span style="color: black;">包含</span>系统性红斑狼疮、类风湿关节炎或牛皮癣等。经过一波三折的<span style="color: black;">科研</span>，它已<span style="color: black;">作为</span>治疗这类风湿免疫性<span style="color: black;">疾患</span>的标准<span style="color: black;">药品</span>。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">左旋咪唑</span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">这个声名远播的广谱</span><strong style="color: blue;"><span style="color: black;">驱肠虫药</span></strong><span style="color: black;">，在1966年人工合成，<span style="color: black;">重点</span>用于驱蛔虫及钩虫等寄生虫，曾用别名</span><strong style="color: blue;"><span style="color: black;">左旋驱虫净</span></strong><span style="color: black;">。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/16408e80c8d04c1599a51f034d23461a~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=emlTgLWat0ZrngWjQU%2F04S9xAP0%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">自从它在中国自主生产，就把曾经的全民驱虫药</span><strong style="color: blue;"><span style="color: black;">宝塔糖</span></strong><span style="color: black;">给淘汰了。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p26-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/a0034dfedfda4450afd84061176cc050~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=f3EABLS1YTilTiYklb0UTJwhC0g%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">1971年<span style="color: black;">发掘</span></span><strong style="color: blue;"><span style="color: black;">左旋咪唑</span></strong><span style="color: black;">还<span style="color: black;">拥有</span>调节免疫功能的<span style="color: black;">功效</span>，<span style="color: black;">能够</span><span style="color: black;">加强</span>病人对细菌及病毒感染的抵抗力。<span style="color: black;">此刻</span><span style="color: black;">重点</span>用它治疗自体免疫性疾病，如类风湿关节炎、红斑性狼疮，以及上<span style="color: black;">呼气</span>道感染、肝炎、菌痢、疮疖、脓肿等。对顽固性支气管哮喘，近期疗效<span style="color: black;">明显</span>。<span style="color: black;">亦</span>用于治疗血小板减少性紫癜。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/3134a7fdd14a4fb89c776f3613f3a4c0~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=fjUw5X8ansPn6ZAPMbIei3WlZ2o%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">日前</span>还将其试用于肺癌、乳腺癌手术后或急性白血病、恶化淋巴瘤化疗后，<span style="color: black;">做为</span>辅助治疗。为了减少口服带来的副<span style="color: black;">功效</span>，<span style="color: black;">亦</span>把它做成涂布剂，<span style="color: black;">经过</span>皮肤给药透皮吸收。外用在治疗顽固性皮肤瘙痒症、复发性腔溃疡等<span style="color: black;">疾患</span>方面<span style="color: black;">亦</span>有良好效果。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">当然，它<span style="color: black;">亦</span>用在了兽药中，给动物防病。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">氨来呫诺</span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">本来它是防治支气管哮喘的，<span style="color: black;">亦</span>做成喷雾剂治疗过敏性鼻炎。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">上世纪90年代，日本有个年近70老太年视力<span style="color: black;">欠好</span>，错将</span><strong style="color: blue;"><span style="color: black;">氨来咕诺鼻腔喷雾剂</span></strong><span style="color: black;">当做口腔清新剂喷在了嘴里。<span style="color: black;">不想</span><span style="color: black;">次日</span>早上，老太多日的</span><strong style="color: blue;"><span style="color: black;">口腔溃疡</span></strong><span style="color: black;">喷好了。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/2fc1d61ba1d2439eaa0ea2f5a4f7221d~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=Js7XaxqAa%2B6xOOanTcFovukkB3g%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">日本某<span style="color: black;">药品</span><span style="color: black;">科研</span>所随即进行了<span style="color: black;">关联</span>实验。美国一家<span style="color: black;">机构</span>得知<span style="color: black;">这事</span>后，重金买下了所有资料，花了5年时间将</span><strong style="color: blue;"><span style="color: black;">氨来咕诺</span></strong><span style="color: black;"><span style="color: black;">研发</span>成专治</span><strong style="color: blue;"><span style="color: black;">口腔溃疡</span></strong><span style="color: black;">的新药，于1996年上市。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/de33a8a9fed94008b125473f46727ca9~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=7%2BainjPk5V588ZgybU047DJgq3s%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;"><span style="color: black;">老树新芽</span></span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;"><span style="color: black;">拓展领地</span></span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">阿司匹林抗血栓</span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">阿司匹林</span></strong><span style="color: black;">于1898年上市，是家喻户晓的</span><strong style="color: blue;"><span style="color: black;">解热<span style="color: black;">止疼</span></span></strong><span style="color: black;">百年老药，涵盖了<span style="color: black;">全部</span>二十世纪。直到如今，每年</span><strong style="color: blue;"><span style="color: black;">阿司匹林</span></strong><span style="color: black;">的<span style="color: black;">全世界</span>产量仍多达五万吨，相当于1000亿片！<span style="color: black;">能够</span>说是药界奇迹。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/b1b8db6fe8404a77888e464fea5cebd8~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=eS3ngEnKGuhlfz9Hy%2FWohRZrvWw%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">在1940年代，美国一位耳鼻喉科<span style="color: black;">大夫</span></span><strong style="color: blue;"><span style="color: black;">克雷文</span></strong><span style="color: black;"><span style="color: black;">重视</span>到，扁桃体发炎的病人<span style="color: black;">运用</span><span style="color: black;">很强</span>剂量</span><strong style="color: blue;"><span style="color: black;">阿司匹林</span></strong><span style="color: black;">会<span style="color: black;">引起</span><span style="color: black;">流血</span><span style="color: black;">太多</span>。他联想到，</span><strong style="color: blue;"><span style="color: black;">阿司匹林</span></strong><span style="color: black;">可能有抗血小板凝血的<span style="color: black;">功效</span>，或许能用在预防心肌梗塞方面。他<span style="color: black;">起始</span>搜集临床资料，并<span style="color: black;">发布</span>了不少这方面的论文。</span><strong style="color: blue;"><span style="color: black;">克雷文</span></strong><span style="color: black;">的判断<span style="color: black;">最终</span>在1971年被一位英国学者确定。<span style="color: black;">此刻</span></span><strong style="color: blue;"><span style="color: black;">阿司匹林</span></strong><span style="color: black;">俨然<span style="color: black;">作为</span>了心脑血管等代谢性<span style="color: black;">疾患</span>的一线防治<span style="color: black;">药物</span>。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/3129e8cd180c4453bb1ff633943a3ecc~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=z%2B8yZeyRkKI%2FNRzunQmk5sFfMj4%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">阿司匹林</span></strong><span style="color: black;">虽然老，可<span style="color: black;">持续</span>有新用途被发掘出来。陆<span style="color: black;">持续</span>续<span style="color: black;">发掘</span></span><strong style="color: blue;"><span style="color: black;">阿司匹林</span></strong><span style="color: black;">还有延缓<span style="color: black;">痴傻</span>、降低肠息肉和肠癌发病率的效果。直到近来，<span style="color: black;">发掘</span>它还有抗衰老等<span style="color: black;">功效</span>。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">米索前列醇治溃疡</span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">阿司匹林</span></strong><span style="color: black;">的生理<span style="color: black;">功效</span>机制，与<span style="color: black;">控制</span><span style="color: black;">身体</span>的</span><strong style="color: blue;"><span style="color: black;">前列腺素</span></strong><span style="color: black;">合成<span style="color: black;">相关</span>，而</span><strong style="color: blue;"><span style="color: black;">前列腺素</span></strong><span style="color: black;">有<span style="color: black;">守护</span>胃粘膜<span style="color: black;">功效</span>。因而胃粘膜容易损害是</span><strong style="color: blue;"><span style="color: black;">阿司匹林</span></strong><span style="color: black;">的<span style="color: black;">重点</span>副<span style="color: black;">功效</span>之一，这正是它<span style="color: black;">控制</span>了</span><strong style="color: blue;"><span style="color: black;">前列腺素</span></strong><span style="color: black;">合成的结果。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/65a1296deff34a349b4248d13bb4a4e0~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=pnBFd%2BvdHs7NyXcxTbrpbmU86qs%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">而人工合成的前列腺素E1衍生物</span><strong style="color: blue;"><span style="color: black;">米索前列醇</span></strong><span style="color: black;">，<span style="color: black;">本来</span>是用于抗早孕和<span style="color: black;">药品</span>流产的，<span style="color: black;">亦</span><span style="color: black;">便是</span>俗<span style="color: black;">叫作</span>的打胎药。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">然而利用它<span style="color: black;">拥有</span>的</span><strong style="color: blue;"><span style="color: black;">前列腺素</span></strong><span style="color: black;"><span style="color: black;">功效</span>，正好转而用来<span style="color: black;">守护</span>胃及十二指肠粘膜，用于抗溃疡的药商品名</span><strong style="color: blue;"><span style="color: black;">喜克溃</span></strong><span style="color: black;">。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/97aa40b831484f6a9ac24eab3137bc16~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=%2BQYsbb4zSa7k8%2BkRxANqXhOOiGA%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;"><span style="color: black;">由此及彼</span></span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;"><span style="color: black;">治疗脱发</span></span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">有些</span></span><strong style="color: blue;"><span style="color: black;">治疗脱发</span></strong><span style="color: black;">的<span style="color: black;">药品</span><span style="color: black;">亦</span>是从其他<span style="color: black;">行业</span>挖来的。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">米诺地尔</span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">名字带“</span><strong style="color: blue;"><span style="color: black;">地尔</span></strong><span style="color: black;">”的<span style="color: black;">药品</span>多多少少都与心血管病<span style="color: black;">相关</span>，<span style="color: black;">例如</span>丁咯地尔、吡贝地尔、前列地尔等。它们除了在心血管方面发挥特长外，还各怀“特技”，都另有其他本事。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/a836f43bb5d94aeeb9dd3d2a63e4aec0~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=DT0vxtXXxovcPxuYH9%2B1PT3ek6s%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">其中有个</span><strong style="color: blue;"><span style="color: black;">米诺地尔</span></strong><span style="color: black;">，<span style="color: black;">拥有</span>强大的小动脉扩张<span style="color: black;">功效</span>，是<span style="color: black;">做为</span>口服降压药1979年上市的，不到10年它又<span style="color: black;">成为了</span></span><strong style="color: blue;"><span style="color: black;">治脱发药</span></strong><span style="color: black;">。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">在<span style="color: black;">起始</span>用</span><strong style="color: blue;"><span style="color: black;">米诺地尔</span></strong><span style="color: black;">治疗高血压时，<span style="color: black;">发掘</span>服用的<span style="color: black;">病人</span>中有80%以上，会在3~6周内<span style="color: black;">显现</span><span style="color: black;">区别</span>程度的毛发变浓或增粗。服药时间一长还有不少的病人<span style="color: black;">显现</span>了<span style="color: black;">区别</span>程度的多毛症。于是把</span><strong style="color: blue;"><span style="color: black;">米诺地尔</span></strong><span style="color: black;">用在了治疗脱发上。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/05ebd1ff91de4b7080ff1ba486f98c68~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=8L3fajLZZtQfBzRF%2BHk0bym7k4E%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">将</span><strong style="color: blue;"><span style="color: black;">米诺地尔</span></strong><span style="color: black;">制成溶液或糊剂，涂抹于头皮，对最<span style="color: black;">平常</span>的</span><strong style="color: blue;"><span style="color: black;">雄激素脱发</span></strong><span style="color: black;">（或<span style="color: black;">叫作</span>“脂溢性脱发）有良好的疗效。它的局部外用<span style="color: black;">亦</span>对治疗瘢痕性脱发（斑秃）有效。1988年，</span><strong style="color: blue;"><span style="color: black;">米诺地尔溶液</span></strong><span style="color: black;">正式在美国上市，此后进入数十个国家<span style="color: black;">营销</span>。在中国，外用</span><strong style="color: blue;"><span style="color: black;">米诺地尔</span></strong><span style="color: black;">制剂属于非处方药。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/ffaaa99524344b73915805e57e310e74~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=gyTlHK%2FAk0ZFrqnQqbwzIQYV9H0%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">螺内酯</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">是一种人工合成的甾体利尿剂，20世纪50年代<span style="color: black;">研发</span>，60年代广泛应用。它又叫安体舒通。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/2fc959d739b84d40941ac4f3ffa3f9e6~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=tCMLuyUZXRfbUiNKd6S1XhhqJck%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">同期</span>它还能<span style="color: black;">控制</span>雄激素产生，从而减少雄激素对皮脂腺的刺激，可用来治疗痤疮。既然有抗雄激素的<span style="color: black;">功效</span>，因而<span style="color: black;">亦</span>拿来治疗</span><strong style="color: blue;"><span style="color: black;">雄激素脱发</span></strong><span style="color: black;">了。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/d059e4b8d34047029272e9e4777a6d29~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=a6Tf%2F32ObqCsJV0csX25yUNisXk%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">非那雄胺</span></span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">它是治疗前列腺增生的常用<span style="color: black;">药品</span>（商品名保列治），利用它的抗雄激素<span style="color: black;">功效</span>，正好<span style="color: black;">能够</span><span style="color: black;">调节</span>剂量治疗</span><strong style="color: blue;"><span style="color: black;">雄激素脱发</span></strong><span style="color: black;">。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/4fde5f01efa94147a43a5b53557e25f2~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=xmvz5X3GHllK5o3ZX%2FrrVHHAZJM%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">另一个抗雄激素的</span><strong style="color: blue;"><span style="color: black;">贝美前列素</span></strong><span style="color: black;">，<span style="color: black;">本来</span>是用于治疗青光眼的。在滴眼<span style="color: black;">病人</span>中，不少睫毛由短变长了，后来<span style="color: black;">亦</span>用于治疗睫毛<span style="color: black;">稀疏</span>症。类似<span style="color: black;">制品</span>还有</span><strong style="color: blue;"><span style="color: black;">比马前列素</span></strong><span style="color: black;">等。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/6766fe05eec74a6cbf6b49aafa0da0f8~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=%2FHxMFg1o5exd%2BN%2BGPH3IOm5W6cA%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">当然，<span style="color: black;">药品</span>不可能个个有效，否则葛优、孟非等人早就治好了。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">总之，人们在新药<span style="color: black;">研发</span>的大道上突进前行时，时不时会有意“</span><strong style="color: blue;"><span style="color: black;">回头望</span></strong><span style="color: black;">”。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/8ebe77b5454444bca70bbaeccf78be0e~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1723570128&amp;x-signature=MkkxMC5WMYWvJQtnln3sL3qMZWQ%3D" style="width: 50%; margin-bottom: 20px;"></div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">还有不少失败后爬起来，又有了新<span style="color: black;">发掘</span>的<span style="color: black;">药品</span>。且听下回继续。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">未完待续</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">以上<span style="color: black;">照片</span>未注明出处者，<span style="color: black;">通常</span>来自网络</span></p>




流星的美 发表于 2024-8-29 21:53:37

我完全同意你的观点，说得太对了。

taiker 发表于 2024-8-31 12:45:41

你的见解真是独到，让我受益匪浅。

4lqedz 发表于 2024-10-2 21:37:05

可以发布外链的网站 http://www.fok120.com/

b1gc8v 发表于 2024-10-31 03:15:19

感谢您的精彩评论，为我带来了新的思考角度。
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