第五届中国微生态医疗创新论坛盛大开启!海内外专家学者在线探讨微生态医疗新发展
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">线上直播:知识盛宴</p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2022年11月5日,第七届整合肝肠病学学术年会暨第五届中国科技产业化促进会微生态医疗创新论坛在广州召开。因受新冠肺炎疫情影响,本届论坛采用线上直播形式举行,来自海内外的微生态学、消化科的专家学者千里连线,共赴这一场盛会,为观众们奉献了一场干货满满的知识盛宴。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">院士论坛:聚焦前沿</p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">最具价值的当属在上午举行的院士论坛,来自中国工程院的樊代明院士、李兆申院士和吴清平院士,分享了《疫后消化病学发展的思考》、《关于幽门螺杆菌的故事》以及《<span style="color: black;">要紧</span>健康微生物菌种定向选育及功能<span style="color: black;">制品</span><span style="color: black;">开发</span>》等课题。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">樊代明院士介绍了他负责主编的《整合消化病学》、《整合肿瘤学》、《整合肿瘤指南》等著作,为消化病学的发展指明了方向,<span style="color: black;">知道</span>了标准。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">李兆申院士说明了根除幽门螺杆菌(HP)<span style="color: black;">能够</span>有效预防胃癌的<span style="color: black;">出现</span>,降低胃癌的发病率,介绍了国内有共识的根除HP的7种<span style="color: black;">办法</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">吴清平院士<span style="color: black;">仔细</span><span style="color: black;">诠释</span>了微生态产业发展的需求:微生物资源的战略地位日益凸显,<span style="color: black;">研发</span>利用的前景非常广阔,微生物检测<span style="color: black;">已然</span><span style="color: black;">作为</span>非常<span style="color: black;">要紧</span>的产业。吴院士分析:肠道微生物的<span style="color: black;">科研</span>方向与胃肠病学、营养学、遗传学等学科<span style="color: black;">关联</span>;近年来,微生物制剂越来越受到广泛的关注;肠道微生物与许多<span style="color: black;">疾患</span>都有非常密切的关系,<span style="color: black;">包含</span>胃肠道<span style="color: black;">疾患</span>、代谢性<span style="color: black;">疾患</span>、肿瘤、精神<span style="color: black;">疾患</span>、心血管系统、<span style="color: black;">自己</span>免疫<span style="color: black;">疾患</span>、肝病等等。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">《肠道微生态和肿瘤<span style="color: black;">基本</span>与转化<span style="color: black;">科研</span><span style="color: black;">发展</span>》</p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">香港中文大学医学院助理院长于君教授,分享了课题《肠道微生态和肿瘤<span style="color: black;">基本</span>与转化<span style="color: black;">科研</span><span style="color: black;">发展</span>》。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">课题亮点</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1、在探索肠道微生态改变所<span style="color: black;">导致</span>的肿瘤<span style="color: black;">出现</span>发展的关系<span style="color: black;">科研</span>中,<span style="color: black;">已然</span><span style="color: black;">发掘</span>了<span style="color: black;">反常</span>的细菌,<span style="color: black;">能够</span>促进肠癌细胞的增殖,<span style="color: black;">控制</span>免疫细胞的<span style="color: black;">功效</span>;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2、下一步<span style="color: black;">科研</span>,各类促癌菌组合<span style="color: black;">针对</span>肠癌的发展机制;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">3、宿主的基因<span style="color: black;">亦</span><span style="color: black;">能够</span><span style="color: black;">经过</span>肠道细菌的<span style="color: black;">形成</span>和代谢的<span style="color: black;">形成</span>,使肠道变得不健康,以促进它所诱导的肠癌的<span style="color: black;">出现</span>和发展;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">4、高脂<span style="color: black;">膳食</span>会促进肠癌的<span style="color: black;">出现</span>发展;吸烟<span style="color: black;">亦</span><span style="color: black;">作为</span>诱导肠癌的一个<span style="color: black;">要紧</span><span style="color: black;">原因</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">《升阳法对肠道菌群<span style="color: black;">错乱</span>的调节<span style="color: black;">功效</span>》</p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">广东药科大学<span style="color: black;">恢复</span>治疗系<span style="color: black;">专家</span>赵昌林教授,分享了课题《升阳法对肠道菌群<span style="color: black;">错乱</span>的调节<span style="color: black;">功效</span>》。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">课题亮点</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1、肿瘤的放化疗会<span style="color: black;">引起</span>肠道菌群的改变,有益菌双歧杆菌数和普氏栖粪杆菌数的丰度下降,而病源菌,包括克雷伯菌属和肠球菌属<span style="color: black;">显著</span>地<span style="color: black;">增多</span>;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2、肠道菌群是一个动态平衡的过程,当细菌的总数繁殖过度的时候,<span style="color: black;">便是</span>有害的;当细菌数量减少的时候,可能是有益的,<span style="color: black;">亦</span>可能分泌<span style="color: black;">有些</span>有益的物质;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">3、中药复方<span style="color: black;">能够</span>有效扶持双歧杆菌、乳酸菌等厌氧菌菌群,并<span style="color: black;">控制</span>长杆菌、肠球菌的生长,疗效优于常聚半乳糖,能<span style="color: black;">加强</span>肠道的免疫力。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">《<span style="color: black;">提高</span>肠菌移植有效性的新探索》</p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">广西大学原副校长、博士生导师魏远安教授,分享了课题《<span style="color: black;">提高</span>肠菌移植有效性的新探索》。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">课题亮点</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1、针对胃肠道<span style="color: black;">疾患</span>,像艰难梭菌感染、炎症性肠病等<span style="color: black;">疾患</span>的诱因和肠道菌群失调紧密<span style="color: black;">关联</span>,<span style="color: black;">因此呢</span>,肠菌移植疗法近年来<span style="color: black;">逐步</span>兴起;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2、菌种定植率和肠菌移植效果呈正<span style="color: black;">关联</span>,<span style="color: black;">亦</span><span style="color: black;">便是</span>说,定植率高,移植的效果就更好;肠菌移植采用联合给药途径<span style="color: black;">能够</span><span style="color: black;">增多</span>微生物<span style="color: black;">移植</span>的可能性;不同细菌的<span style="color: black;">移植</span>率是有差异的,厚壁菌门、变形菌门、拟杆菌门、放线菌门的平均菌株<span style="color: black;">移植</span>率会更高;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">3、在肠粘膜的<span style="color: black;">损害</span>和愈合<span style="color: black;">持续</span>变化平衡的过程中,肠道免疫细胞与肠屏障相互<span style="color: black;">功效</span>;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">4、在肠菌移植前,受体最好先<span style="color: black;">评定</span><span style="color: black;">检测</span>肠屏障功能的<span style="color: black;">状况</span>,预防可能的严重菌群移位情况的<span style="color: black;">出现</span>;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">5、在肠菌移植前,受体肠道菌群抗生素的冲击,和益生元预<span style="color: black;">守护</span><span style="color: black;">干涉</span>,这两点值得进一步探索。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">《<span style="color: black;">精细</span>肠菌移植在肿瘤的应用与前景》</p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">广东省中西医结合整合肝肠病学专业委员会副<span style="color: black;">专家</span>委员何剑全<span style="color: black;">科研</span>员,分享了课题《<span style="color: black;">精细</span>肠菌移植在肿瘤的应用与前景》。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">课题亮点</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1、肠道菌群<span style="color: black;">能够</span><span style="color: black;">做为</span>癌症的辅助诊断以及疗效的预测,<span style="color: black;">同期</span>在治疗过程中相应的毒副<span style="color: black;">功效</span>在菌群的<span style="color: black;">干涉</span>下<span style="color: black;">能够</span>得到<span style="color: black;">明显</span>的缓解;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2、从机制的<span style="color: black;">方向</span>,<span style="color: black;">能够</span><span style="color: black;">发掘</span>,肿瘤部位的菌群<span style="color: black;">能够</span>影响宿主的基因,<span style="color: black;">同期</span>诱发肿瘤的<span style="color: black;">出现</span>发展;肠道菌群<span style="color: black;">亦</span><span style="color: black;">能够</span>影响免疫的环境,促进肿瘤的生长,<span style="color: black;">同期</span>会影响免疫治疗的过程中耐药的机制;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">3、临床<span style="color: black;">科研</span><span style="color: black;">发掘</span>:肠菌移植<span style="color: black;">能够</span>逆转免疫治疗的耐药;<span style="color: black;">同期</span>,针对抗生素<span style="color: black;">导致</span>的<span style="color: black;">有些</span>不良反应、菌群失衡,肠菌移植<span style="color: black;">亦</span><span style="color: black;">能够</span>发挥<span style="color: black;">必定</span>的效果;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">4、特定供体的肠道菌群,<span style="color: black;">亦</span>决定了逆转免疫治疗耐药的<span style="color: black;">重要</span><span style="color: black;">原因</span>,<span style="color: black;">因此</span>,<span style="color: black;">针对</span>供体的肠道菌群分析以及<span style="color: black;">可否</span>实现<span style="color: black;">精细</span>化的移植<span style="color: black;">供给</span>了非常好的依据;<span style="color: black;">病人</span>的肠道菌群要<span style="color: black;">经过</span><span style="color: black;">必定</span>的变化,并接近于供体,<span style="color: black;">才可</span>实现免疫治疗耐药的逆转;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">5、肠菌移植<span style="color: black;">另一</span>一个<span style="color: black;">功效</span>是<span style="color: black;">能够</span>减轻癌症<span style="color: black;">关联</span><span style="color: black;">药品</span>的不良反应。</p>
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