鹿明生物大盘点 | 最受瞩目的8项癌症行业科研文案~
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">从人类诞生之初，就在<span style="color: black;">一直</span>的与<span style="color: black;">各样</span><span style="color: black;">疾患</span>做着斗争，其中与癌症的抗争从未熄火。从最初<span style="color: black;">认识</span>肿瘤的临床表现，到<span style="color: black;">此刻</span>利用新型的空间<span style="color: black;">影像</span>技术看到生物组织的空间分布等等。新技术的运用和多组学的联合分析进入了癌症<span style="color: black;">行业</span>的<span style="color: black;">科研</span>视野，让<span style="color: black;">专家</span>们“独具慧眼”，破解了一个又一个未知的谜团。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本期，<span style="color: black;">博主</span>分享最受瞩目的8项癌症<span style="color: black;">科研</span>文章，<span style="color: black;">期盼</span>能给各位学者老师的<span style="color: black;">研究</span>有所助益~</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">1</strong></p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">人结核病变组织-肉芽肿中炎症信号的空间分布<span style="color: black;">科研</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Inflammatory signaling in human tuberculosis granulomas is spatially organized</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">发布</span>期刊：</strong>Nature medicine</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">影响因子：</strong>53.440</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">物种：</strong>
</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">人结核肉芽肿组织</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">组学技术：</strong><strong style="color: blue;">空间代谢组学</strong>、激光显微切割技术、<strong style="color: blue;">Label free蛋白质组</strong>、免疫组化(IHC)、<strong style="color: blue;">LC-MS靶向代谢组学</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>思路：</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-7287298a74e60b7b131a98c438f54fbe_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>结论：</strong></p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图 | 空间代谢组学分析人体组织中含有AA的脂类和AA的<span style="color: black;">影像</span>图</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">综上肉芽肿中心坏死组织有一个促炎症环境。相反，肉芽肿<span style="color: black;">周边</span>的活性组织<span style="color: black;">拥有</span>相对消炎的特征，这些特征在人和兔子样本中一致，即宿主<span style="color: black;">控制</span>结核分枝杆菌和限制宿主<span style="color: black;">损害</span>的能力是一种局限于单个肉芽肿水平的现象。当然，肉芽肿之间的细菌负荷和免疫激活存在<span style="color: black;">明显</span>差异，即使在同一宿主内<span style="color: black;">亦</span>是如此。尽管此结果<span style="color: black;">必须</span>在更大的样本集中得到证实，但本文<strong style="color: blue;">空间代谢组学+多组学技术</strong><span style="color: black;">科研</span>数据<span style="color: black;">显示</span>，真正的平衡<span style="color: black;">出现</span>在局部，系统性<span style="color: black;">干涉</span>可能相当<span style="color: black;">繁杂</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">2</strong></p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">黑色素瘤对免疫治疗响应的蛋白质组学<span style="color: black;">科研</span>揭示线粒体依赖性</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">发布</span>期刊：</strong>Cell</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">影响因子：</strong>41.582</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">物种：</strong>黑色素瘤</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">组学技术：</strong><strong style="color: blue;">蛋白质组学</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>思路：</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic1.zhimg.com/80/v2-1c50459b78c0b9f80252a27977fe7b5c_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>结论：</strong></p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图 | 黑色素瘤对免疫治疗响应的蛋白质组学</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">免疫疗法彻底改变了癌症的治疗<span style="color: black;">办法</span>，<span style="color: black;">然则</span>大<span style="color: black;">都数</span><span style="color: black;">病人</span><span style="color: black;">无</span>响应。本文<span style="color: black;">经过</span><strong style="color: blue;">蛋白质组学</strong><strong style="color: blue;"><span style="color: black;">科研</span>来自肿瘤浸润淋巴细胞（TIL）治疗或抗PD1免疫治疗的晚期黑色素瘤<span style="color: black;">病人</span>的临床样品</strong>。统计分析<span style="color: black;">显示</span>在两种治疗中，响应组的氧化磷酸化和脂质代谢均高于非响应组。为了阐明代谢状态对免疫响应的影响，作者在代谢扰动或CRISPR-Cas9敲除后<span style="color: black;">检测</span>了黑色素瘤细胞。这些实验结果<span style="color: black;">显示</span>脂质代谢是<span style="color: black;">经过</span><span style="color: black;">加强</span>抗原呈递而<span style="color: black;">增多</span>黑素瘤免疫原性，从而<span style="color: black;">增多</span>了对T细胞杀伤的<span style="color: black;">敏锐</span>性。总的<span style="color: black;">来讲</span>，<strong style="color: blue;">蛋白质组学分析揭示了黑色素瘤代谢状态与免疫治疗响应之间的<span style="color: black;">相关</span>，这可能有助于将来改善治疗响应。</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">3</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic2.zhimg.com/80/v2-58564457176bd2ad03e63524d2cd1029_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">纵向多组学揭示了肠易激<span style="color: black;">综合症</span><span style="color: black;">暗地里</span>的亚结构特定机制</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">期刊：</strong>Cell</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">影响因子：</strong>41.582</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">物种：</strong>粪便、血液、结肠组织</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">组学技术：</strong>肠道微生物组、代谢组、宿主表观基因组和转录组</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>思路：</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic4.zhimg.com/80/v2-29a11cb52f83311f2589e371d5f3d443_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>结论：</strong></p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图 | IBS-C<span style="color: black;">病人</span>的肠道菌群<span style="color: black;">构成</span>更加<span style="color: black;">显著</span>且易变</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本文作者整合了<strong style="color: blue;">肠道微生物组、代谢组、宿主表观基因组和转录组的纵向多组学数据，</strong>以肠易激<span style="color: black;">综合症</span>（IBS）宿主生理为背景，确定了IBS亚型特异性和症状<span style="color: black;">关联</span>的微生物<span style="color: black;">构成</span>和功能变异特征。部分<span style="color: black;">出现</span>变化的微生物代谢产物对应于与IBS<span style="color: black;">关联</span>的宿主生理机制。<span style="color: black;">经过</span>整合多组学数据，确定嘌呤代谢是IBS的一种新型宿主-微生物代谢途径。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">4</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic1.zhimg.com/80/v2-0d2f75be9bc71d5f3ed34ced68b21a70_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">人类恶性胶质瘤的蛋白基因组学和代谢组学图谱</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Proteogenomic and metabolomic characterization of human glioblastoma</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">期刊：</strong>Cancer Cell</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">影响因子：</strong>31.743</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>对象：</strong>人胶质母细胞癌</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">发布</span>时间：</strong>2021年2月</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">组学技术：</strong>全基因组测序（WGS）、全外显子测序（WES）、全转录组测序（RNA-seq）、小RNA测序（miRNA-seq）、单细胞核测序（snRNA-seq）、DNA甲基化芯片、蛋白质组学、修饰（磷酸化，乙酰化）蛋白质组学、代谢组学、脂质组学等</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>思路：</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic2.zhimg.com/80/v2-4aa3260cd37343563d96f0516daa94c5_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>结论：</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic2.zhimg.com/80/v2-cd76c981276be1a435b704f5f3117ed1_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图1 | GBMs队列的蛋白基因组图谱总览</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>人员<span style="color: black;">经过</span>整合来自10个平台的<strong style="color: blue;">蛋白基因组学和代谢组学数据</strong>，鉴定到了<span style="color: black;">重要</span>的磷酸化事件（如，磷酸化的PTPN11和PLCG1），这些磷酸化蛋白是介<span style="color: black;">引起</span>癌途径激活的潜在开关和EGFR-，TP53-和RB1-变异型肿瘤的潜在靶标。<span style="color: black;">运用</span>普通组学<span style="color: black;">办法</span><span style="color: black;">发掘</span>了GBMs<span style="color: black;">拥有</span>不同免疫细胞类型的免疫亚型，<strong style="color: blue;">并<span style="color: black;">经过</span>snRNA-seq进行验证</strong>，而这些亚型又与特异性表达和组蛋白乙酰化模式<span style="color: black;">关联</span>。经典类和免疫性低的GBMs中的组蛋白H2B乙酰化<span style="color: black;">重点</span>受BRD，CREBBP和EP300的驱动。全面的<strong style="color: blue;">代谢组学和蛋白质组学</strong>数据证实了IDH突变型肿瘤中各亚型的特定脂质分布和<span style="color: black;">明显</span>各异的整体代谢变化。这项<span style="color: black;">科研</span>所挖掘聚焦的生物学关系可能有助于GBMs<span style="color: black;">病人</span>分型，并能有效的<span style="color: black;">指点</span>个性化<span style="color: black;">精细</span>治疗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">5</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">转移性结直肠癌的多组学<span style="color: black;">科研</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Integrated Omics of Metastatic Colorectal Cancer</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">期刊：</strong>Cancer Cell</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">影响因子：</strong>31.743</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>对象：</strong>结直肠癌</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">组学技术：</strong><strong style="color: blue;">基因组学、蛋白质组学、磷酸化蛋白质组学、药敏实验</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>思路<strong style="color: blue;">：</strong></strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>结论：</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"> 图3 | CCRC的<strong style="color: blue;">磷酸化蛋白质图谱</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本文作者整合了来自中国结直肠癌队列中146例<span style="color: black;">病人</span>的480个临床样本的<strong style="color: blue;">基因组学，蛋白质组学和磷酸化蛋白质组学</strong>。蛋白质组学将CRC分为三种亚型，每种亚型<span style="color: black;">拥有</span>不同的临床预后和分子特征。对原发灶的<strong style="color: blue;">蛋白质组学</strong>和<strong style="color: blue;">磷酸化蛋白质组学</strong>
</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">分析，<span style="color: black;">能够</span>成功地区分转移病例。转移组织在遗传学上与原发灶表现出高度<span style="color: black;">类似</span>性，但在蛋白质组学水平上却差异<span style="color: black;">很强</span>，并且激酶网络分析<span style="color: black;">表示</span>原发灶肿瘤与其肝转移灶肿瘤之间存在<span style="color: black;">明显</span>的异质性。<span style="color: black;">运用</span>31种原发性和转移性肿瘤的<span style="color: black;">身体</span>异种移植<span style="color: black;">药品</span>测试<span style="color: black;">表示</span>出个性化反应，且<span style="color: black;">能够</span><span style="color: black;">经过</span>激酶-底物网络分析预测，而这与<span style="color: black;">药品</span>靶标基因<span style="color: black;">可否</span>突变<span style="color: black;">没</span>关。本<span style="color: black;">科研</span>为更好地<span style="color: black;">认识</span>mCRC<span style="color: black;">供给</span>了宝贵的资源，并<span style="color: black;">拥有</span>临床应用<span style="color: black;">潜能</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">6</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">粪便宏基因组和血清代谢组的整合分析揭示肠道微生物组<span style="color: black;">关联</span>代谢物在结直肠癌和腺瘤检测的<span style="color: black;">功效</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome- associated metabolites in the detection of colorectal cancer and adenoma</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">期刊：</strong>Gut</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">影响因子：</strong>23.059</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>对象：</strong>人粪便，血清，组织</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">组学技术：</strong>AFADESI-MSI空间代谢组学、LC-MS非靶代谢组、宏基因组、靶向代谢组学</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">其中宏基因组由欧易生物完成，空间代谢组学由贺玖明教授团队<span style="color: black;">供给</span>技术支持</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>思路：</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>结论：</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图| 直肠腺瘤/肿瘤和癌旁活检组织的质谱<span style="color: black;">影像</span>结果</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">CRC <span style="color: black;">病人</span>的肠道微生物组重编程与血清代谢组的改变<span style="color: black;">相关</span>。本<span style="color: black;">科研</span><span style="color: black;">经过</span><strong style="color: blue;">非靶向代谢技术</strong><span style="color: black;">发掘</span>885种血清代谢物在CRC和腺瘤中<span style="color: black;">出现</span><span style="color: black;">明显</span>改变，<span style="color: black;">包含</span>8种肠道微生物组<span style="color: black;">关联</span>的血清代谢物（GMSM组）。这8种代谢物可<span style="color: black;">经过</span><strong style="color: blue;">靶向和非靶向代谢组学技术</strong>重复检测，并准确区分CRC/腺瘤与正常样本。基于GMSM组的模型用于预测CRC和结直肠腺瘤，建模队列中的曲线下面积（AUC）为0.98，在验证队列中AUC为0.92，结果<span style="color: black;">显著</span>优于临床标志物癌胚抗原（AUC=0.72）。GMSM组在腺瘤（AUC=0.84）和<span style="color: black;">初期</span> CRC（AUC=0.93）的AUC数据<span style="color: black;">表示</span>出该<span style="color: black;">办法</span>在这两组样本中<span style="color: black;">拥有</span>较高的诊断准确性，<span style="color: black;">表示</span>出GMSM在CRC和腺瘤检测的良好应用<span style="color: black;">基本</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">7</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">CCN2的自噬降解<span style="color: black;">引起</span>舒尼替尼的心脏毒性</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">期刊：</strong>Autophagy</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">影响因子：</strong>16.016</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>对象：</strong>小鼠</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">发布</span>时间：</strong>2021年8月</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">组学技术：</strong><strong style="color: blue;">iTRAQ蛋白质组学</strong>(由鹿明生物<span style="color: black;">供给</span>技术支持)、动物模型、功能实验、免疫组化、Western blot、qPCR、免疫荧光、流式分析、免疫沉淀</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>思路：</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>结论：</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图6 | 舒尼替尼<span style="color: black;">经过</span>自噬-溶酶体通路促进CCN2蛋白的降解</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">过度自噬是心血管<span style="color: black;">疾患</span>或癌症治疗<span style="color: black;">导致</span>心肌细胞死亡的<span style="color: black;">原由</span>之一，但其潜在机制尚不清楚。先前<span style="color: black;">报告</span>自噬可能<span style="color: black;">引起</span>舒尼替尼<span style="color: black;">导致</span>的心肌细胞死亡，这可能有助于理解自噬诱导的心肌细胞死亡的机制。本文<span style="color: black;">发掘</span>舒尼替尼诱导的自噬<span style="color: black;">引起</span>心肌细胞凋亡和心脏功能<span style="color: black;">阻碍</span>。舒尼替尼诱导的适应不良自噬<span style="color: black;">经过</span>TOLLIP介导的内体<span style="color: black;">关联</span>通路<span style="color: black;">选取</span>性降解心肌细胞存活介质CCN2。值得<span style="color: black;">重视</span>的是，Hmgb1的缺失<span style="color: black;">控制</span>了舒尼替尼诱导的心肌细胞自噬和凋亡，而HMGB1特异性<span style="color: black;">控制</span>剂甘草酸（GA）<span style="color: black;">明显</span>减轻了舒尼替尼诱导的自噬、心肌细胞死亡和心脏毒性。本文<span style="color: black;">科研</span>揭示了调节心肌细胞死亡的自噬降解新靶标蛋白，并强调了HMGB1的药理学<span style="color: black;">控制</span>剂<span style="color: black;">做为</span><span style="color: black;">加强</span>基于舒尼替尼的癌症治疗安全性的有吸引力的<span style="color: black;">办法</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">8</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">泛癌lncRNA PLANE调节<span style="color: black;">选取</span>性剪接程序以促进癌症发病</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">期刊：</strong>Nature Communications</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">影响因子：</strong>14.919</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>对象：</strong>细胞系、人组织、小鼠模型</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">发布</span>时间：</strong>2021年6月</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">组学技术：</strong>蛋白质组学质谱鉴定(由鹿明生物<span style="color: black;">供给</span>技术支持)、RNA测序、免疫沉淀、qPCR、免疫荧光</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>思路：</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>结论:</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图| 直肠腺瘤/肿瘤和癌旁活检组织的质谱<span style="color: black;">影像</span>结果</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">染色体3q远端部分的基因组扩增是恶性肿瘤中最<span style="color: black;">平常</span>的染色体<span style="color: black;">反常</span>之一。本文在功能上表征了3q区域的长链非编码RNA (lncRNA) PLANE，它<span style="color: black;">经过</span>拷贝数<span style="color: black;">增多</span>和E2F1介导的转录激活在不同的癌症类型中上调。PLANE与内含子45处的NCOR2前体mRNA形成RNA-RNA双链体，与hnRNPM结合并促进hnRNPM与内含子的结合，从而<span style="color: black;">引起</span><span style="color: black;">选取</span>性剪切的<span style="color: black;">控制</span>，产生NCOR2-202。这<span style="color: black;">最少</span>部分是PLANE介导的促进癌细胞增殖和致瘤性的<span style="color: black;">原由</span>。这些结果揭示了PLANE的功能，<span style="color: black;">显示</span>PLANE可能<span style="color: black;">形成</span>泛癌背景下的治疗靶点。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">文末看点</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">上海鹿明生物科技有限<span style="color: black;">机构</span><span style="color: black;">数年</span>来，<span style="color: black;">始终</span>专注于生命科学和生命技术<span style="color: black;">行业</span>，是国内<span style="color: black;">初期</span>开展以蛋白组和代谢组为<span style="color: black;">基本</span>的多层组学整合实验与分析的团队。<span style="color: black;">日前</span>正在热推<strong style="color: blue;">“双十一·2周购”</strong>活动，<strong style="color: blue;">空间多组学“火”促中.</strong><strong style="color: blue;">“暖冬大“放价“：</strong><strong style="color: blue;">4D蛋白组学低价抢“鲜”领</strong></p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
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