最新出炉!全世界十大癌症疫苗重磅临床数据颁布!
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">咱们</span><span style="color: black;">必要</span><span style="color: black;">晓得</span>,时<span style="color: black;">迄今</span>日,疫苗仍是人类在<span style="color: black;">疾患</span>产生前预防的最佳武器。而医学从<span style="color: black;">亦</span>未停止对癌症疫苗的<span style="color: black;">科研</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">五十年前,麻疹,腮腺炎和风疹疫苗的<span style="color: black;">研发</span>,人类才得以终结肆虐的天花、脊椎灰质炎等致命<span style="color: black;">疾患</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">倘若</span>癌症<span style="color: black;">亦</span>能被疫苗终结,<span style="color: black;">非常多</span>的悲剧<span style="color: black;">是否</span><span style="color: black;">亦</span>就不会上演?</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">随着医学的进步,个性化癌症疫苗已<span style="color: black;">作为</span><span style="color: black;">精细</span>医疗的<span style="color: black;">目的</span>之一,被全球生物医药<span style="color: black;">机构</span>争先<span style="color: black;">科研</span>,<span style="color: black;">期盼</span>能够<span style="color: black;">经过</span>激活人体<span style="color: black;">自己</span>免疫细胞,来杀灭癌细胞!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">全世界</span> 癌症“ 治疗性疫苗 ” <span style="color: black;">开发</span>遍地开花,在各个癌症中取得了令人振奋的<span style="color: black;">科研</span>数据,<span style="color: black;">全世界</span>肿瘤<span style="color: black;">大夫</span>网医学部查阅了<span style="color: black;">海量</span>文献,为<span style="color: black;">大众</span>总结了<span style="color: black;">拥有</span>重磅数据,并且有望上市的癌症疫苗,<span style="color: black;">期盼</span>给<span style="color: black;">病人</span>多一份<span style="color: black;">期盼</span>和战胜癌症的<span style="color: black;">自信心</span>!</p>
<h2 style="color: black; text-align: left; margin-bottom: 10px;">什么是癌症疫苗?</h2>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">几十年来,癌症疫苗<span style="color: black;">已然</span><span style="color: black;">作为</span>免疫疗法的一种形式,<span style="color: black;">经过</span>刺激或恢复人体<span style="color: black;">自己</span>的免疫系统,来防止癌症发展或杀灭现有的肿瘤。癌细胞表面存在特殊的蛋白质,<span style="color: black;">经过</span>靶向这些蛋白质,免疫系统<span style="color: black;">能够</span>特异性地消除癌细胞,<span style="color: black;">同期</span>不<span style="color: black;">损伤</span>正常的细胞。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">预防性疫苗--HPV疫苗</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">HPV疫苗是最知名的癌症预防性疫苗。它能够预防人乳头瘤病毒感染。<span style="color: black;">已然</span>证实,某些HPV感染与宫颈癌,阴道癌,外阴癌,阴茎癌,肛门癌,直肠癌和头颈癌<span style="color: black;">相关</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">全世界</span><span style="color: black;">独一</span>已<span style="color: black;">获准</span>的治疗型疫苗--Provenge(sipuleucel-T)</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌症治疗性疫苗,<span style="color: black;">首要</span><span style="color: black;">得到</span>美国食品和<span style="color: black;">药品</span>管理局<span style="color: black;">准许</span>的是前列腺癌疫苗Provenge(sipuleucel-T),这种疫苗<span style="color: black;">第1</span>次实现了利用<span style="color: black;">病人</span><span style="color: black;">自己</span>的免疫系统攻击癌细胞的设想。</p>
<h2 style="color: black; text-align: left; margin-bottom: 10px;">癌症疫苗的类型</h2>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">日前</span>正在<span style="color: black;">科研</span>许多不同类型的疫苗来治疗多种癌症。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">肿瘤细胞疫苗:这些疫苗<span style="color: black;">是由于</span>在手术<span style="color: black;">时期</span>从<span style="color: black;">病人</span><span style="color: black;">身体</span>取出的<span style="color: black;">实质</span>癌细胞制成。癌细胞在实验室中被编辑,使它们<span style="color: black;">更易</span>被免疫系统攻击,<span style="color: black;">而后</span>注射回<span style="color: black;">病人</span><span style="color: black;">身体</span>。<span style="color: black;">病人</span>的免疫系统攻击这些细胞和身体中存在的类似细胞。<span style="color: black;">一般</span><span style="color: black;">必须</span><span style="color: black;">按照</span><span style="color: black;">每一个</span>癌症<span style="color: black;">病人</span><span style="color: black;">尤其</span>制作。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">抗原疫苗:这些疫苗只<span style="color: black;">运用</span>一种或几种抗原而不是<span style="color: black;">全部</span>肿瘤细胞来<span style="color: black;">加强</span>免疫系统。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">抗原疫苗<span style="color: black;">能够</span>特定于某种类型的癌症,但它们不是针对特定<span style="color: black;">病人</span>制造的,如自体肿瘤细胞疫苗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">树突状细胞疫苗:迄今为止,这类疫苗在治疗癌症方面取得了最大的成功。被<span style="color: black;">准许</span>用于治疗晚期前列腺癌的 Sipuleucel-T(Provenge)就属于树突细胞疫苗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">树突细胞(DC)是<span style="color: black;">身体</span>特殊的免疫细胞,有助于免疫系统识别癌细胞。<span style="color: black;">她们</span>将癌细胞分解成较小的片段(<span style="color: black;">包含</span>抗原),<span style="color: black;">而后</span><span style="color: black;">保存</span>这些抗原,以便其他被<span style="color: black;">叫作</span>为T细胞的免疫细胞<span style="color: black;">能够</span>识别出<span style="color: black;">她们</span>。<span style="color: black;">而后</span>T细胞<span style="color: black;">起始</span>针对<span style="color: black;">身体</span>含有这些抗原的任何细胞发动攻击。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">“<span style="color: black;">没</span>论是用于预防传<span style="color: black;">患病</span>还是预防和治疗癌症,疫苗都可以<span style="color: black;">经过</span>类似的机制发挥<span style="color: black;">功效</span>:它们<span style="color: black;">教诲</span>免疫系统将传染性病原体或癌细胞识别为<span style="color: black;">必须</span>消除的外来物质,”--纪念斯隆卡瑟琳癌症中心的癌症免疫学家Dmitriy Zamarin 博士。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌细胞表面存在特殊的蛋白质,<span style="color: black;">经过</span>靶向这些蛋白质,免疫系统<span style="color: black;">能够</span>特异性地消除癌细胞,<span style="color: black;">同期</span>不<span style="color: black;">损伤</span>正常的细胞。</p>
<h2 style="color: black; text-align: left; margin-bottom: 10px;"><span style="color: black;">全世界</span>十大癌症疫苗重磅数据<span style="color: black;">颁布</span>!</h2>1NeoVax疫苗<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">NeoVax是一种个性化的实验性疫苗,旨在识别癌症特异性蛋白质,<span style="color: black;">亦</span><span style="color: black;">叫作</span>为新抗原,是特异性存在于癌细胞中但不存在于正常细胞上的的蛋白质。<span style="color: black;">日前</span>正在<span style="color: black;">脑肿瘤</span>,肾癌,黑色素瘤中开展临床<span style="color: black;">实验</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">脑肿瘤</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span><span style="color: black;">周期</span>:Ⅰb期</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span>数据:中位<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期PFS达到16.8个月</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">胶质母细胞瘤被<span style="color: black;">叫作</span>为免疫性“冷”肿瘤,这是<span style="color: black;">由于</span>脑肿瘤含有很少的免疫细胞,大脑中存在着一种叫做血脑屏障的系统,会阻碍T细胞进入大脑组织。想要这些免疫细胞<span style="color: black;">必须</span>产生针对肿瘤的免疫反应非常困难。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">个性化的“新抗原”疫苗<span style="color: black;">能够</span>刺激对胶质母细胞瘤的反应,疫苗产生的免疫T细胞会到达脑肿瘤中,使癌细胞<span style="color: black;">周边</span>产生热的炎症环境,可<span style="color: black;">明显</span>改善胶质母细胞瘤<span style="color: black;">病人</span>的<span style="color: black;">存活</span>期,中位<span style="color: black;">存活</span>期<span style="color: black;">亦</span>达到了16.8个月!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">“这是<span style="color: black;">第1</span>次证明疫苗<span style="color: black;">能够</span>产生针对肿瘤的免疫细胞,<span style="color: black;">能够</span>从血液流入胶质母细胞瘤中,” 该<span style="color: black;">科研</span>的资深作者David Reardon博士说。Reardon是Dana-Farber神经肿瘤学中心的临床<span style="color: black;">专家</span>。<span style="color: black;">日前</span>这款疫苗仅<span style="color: black;">处在</span>临床<span style="color: black;">实验</span><span style="color: black;">周期</span>,<span style="color: black;">咱们</span>期待<span style="color: black;">更加多</span>的临床数据<span style="color: black;">颁布</span>。(NCT03422094 华盛顿大学医学院)详情点击:Nature重磅|新抗癌疫苗取得重大突破,<span style="color: black;">解决</span>实体瘤的梦想终将照进现实!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">黑色素瘤</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span><span style="color: black;">周期</span>:Ⅰb期</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span>数据:2名<span style="color: black;">病人</span>完全缓解</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">去年7月Catherine Wu在nature上<span style="color: black;">发布</span>的<span style="color: black;">科研</span><span style="color: black;">显示</span>:将该疫苗给予6名<span style="color: black;">身患</span>黑素瘤已手术切除病灶并被认为是高度复发<span style="color: black;">危害</span>的<span style="color: black;">病人</span>。在手术后18周<span style="color: black;">起始</span>接种疫苗。在接种后25个月,6名<span style="color: black;">病人</span>中的4名未<span style="color: black;">发掘</span>癌症复发的迹象。<span style="color: black;">另一</span>两名癌症<span style="color: black;">已然</span>扩散到肺部的<span style="color: black;">病人</span>中,疫苗接种后复发。之后,<span style="color: black;">她们</span><span style="color: black;">起始</span>用<span style="color: black;">药品</span>派姆单抗进行治疗,该<span style="color: black;">药品</span><span style="color: black;">控制</span>PD-1免疫<span style="color: black;">检测</span>点。<span style="color: black;">按照</span>影像,两名<span style="color: black;">病人</span>均完全解除肿瘤并保持<span style="color: black;">没</span><span style="color: black;">疾患</span><span style="color: black;">发展</span>。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic2.zhimg.com/80/v2-27c2a18519ad3e2bf64b7018514622c5_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>上图Pt2,<span style="color: black;">亦</span><span style="color: black;">便是</span>实验组中的第2位<span style="color: black;">病人</span>,接受疫苗治疗8周后PET / CT扫描<span style="color: black;">表示</span>右肺门淋巴结肿大2.1cm,疫苗治疗12周后再次扫描<span style="color: black;">表示</span>右肺门淋巴结病的完全消退。Pt6,<span style="color: black;">亦</span><span style="color: black;">便是</span>实验组中的第6位<span style="color: black;">病人</span>,在疫苗治疗1周CT扫描<span style="color: black;">表示</span>左侧外侧和后侧胸壁有多个软组织结节(黄色箭头<span style="color: black;">表示</span>2.1×1.8 ),接受疫苗治疗16.5周后进行CT扫描,<span style="color: black;">表示</span>所有病灶的完全间隔消退。<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">肾癌</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span><span style="color: black;">周期</span>:Ⅰb期</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span>数据:暂<span style="color: black;">没</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2019年初,Dana-Farber癌症<span style="color: black;">科研</span>所的<span style="color: black;">专家</span>们宣布,将正式<span style="color: black;">起始</span>新型个性化癌症疫苗NeoVax与成熟的免疫<span style="color: black;">检测</span>点<span style="color: black;">控制</span>剂结合的临床测试,<span style="color: black;">科研</span>者说,<span style="color: black;">针对</span>手术后复发<span style="color: black;">危害</span>很高的肾癌<span style="color: black;">病人</span><span style="color: black;">来讲</span>,这是一种将改善预后的首创<span style="color: black;">办法</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这项双管齐下的<span style="color: black;">办法</span>旨在调动肾癌<span style="color: black;">病人</span>对手术后留在<span style="color: black;">身体</span>的癌细胞的免疫反应(这可能是癌症后期复发的罪魁祸首),这是<span style="color: black;">第1</span>个<span style="color: black;">评定</span>肾癌<span style="color: black;">病人</span>个性化癌症疫苗的<span style="color: black;">实验</span>。详情可致电<span style="color: black;">全世界</span>肿瘤<span style="color: black;">大夫</span>网医学部。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">该<span style="color: black;">实验</span>将招募15名<span style="color: black;">病人</span>~20名<span style="color: black;">病人</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span>编号:NCT02950766</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span><span style="color: black;">药品</span>:</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1、个性化新抗原癌症疫苗(NeoVax)。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2、Ipilimumab(Yervoy TM)。</p>2SurVaxM疫苗<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">SurVaxM是一款<span style="color: black;">全世界</span>首创的肽模拟肿瘤疫苗,<span style="color: black;">能够</span>靶向一种叫做Survivin的细胞存活蛋白,该蛋白存在于95%的恶性胶质瘤<span style="color: black;">病人</span>和许多其他癌症<span style="color: black;">病人</span>中。SurvAxM<span style="color: black;">拥有</span>刺激T细胞免疫以及抗体导向survivin通路<span style="color: black;">控制</span>的双重<span style="color: black;">功效</span>机制,<span style="color: black;">能够</span><span style="color: black;">掌控</span>肿瘤生长和预防或延缓肿瘤复发。SurVaxM<span style="color: black;">已然</span><span style="color: black;">得到</span>美国FDA孤儿药<span style="color: black;">叫作</span>号。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">开发</span><span style="color: black;">机构</span>:MIMIVAX生物科技<span style="color: black;">机构</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span><span style="color: black;">周期</span>:II期(NCT02455557 招募结束)</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">适应症:针对<span style="color: black;">刚才</span>诊断为胶质母细胞瘤的<span style="color: black;">病人</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span>数据:91%<span style="color: black;">病人</span>总<span style="color: black;">存活</span>期超一年</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">重要</span>的中期结果<span style="color: black;">包含</span>接受SurvAxM联合治疗的<span style="color: black;">病人</span>中有91%的<span style="color: black;">病人</span><span style="color: black;">得到</span>12个月的总<span style="color: black;">存活</span>期(OS-12),历史标准治疗相应<span style="color: black;">存活</span>率为61%;96%的<span style="color: black;">病人</span><span style="color: black;">得到</span>6个月的<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期(PFS-6),而历史标准治疗为54%。在这项<span style="color: black;">科研</span>中,63名<span style="color: black;">病人</span>中有13名在12个月内仍未<span style="color: black;">发展</span>。迄今为止的证据<span style="color: black;">显示</span>,SurVaxM易于给药,安全,耐受性好,副<span style="color: black;">功效</span>小。</p>3DCVax-L<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">加州大学洛杉矶分校的<span style="color: black;">科研</span>人员花费了将近20年的时间致力于激活抗脑癌的树突状细胞。Liau和她的团队是<span style="color: black;">第1</span>批在胶质母细胞瘤<span style="color: black;">病人</span>中测试树突状细胞疫苗的<span style="color: black;">科研</span>人员,<span style="color: black;">由于</span>先前这种肿瘤被认为是<span style="color: black;">拥有</span>免疫特权的,即免疫系统不会攻击它。但Liau和她的同事能够在先前的<span style="color: black;">科研</span>中证明,在接种疫苗后,身体<span style="color: black;">实质</span>上<span style="color: black;">能够</span>对脑部肿瘤产生免疫应答。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic4.zhimg.com/80/v2-5a015d58acfcd1bccac776fe668cac93_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Dendritic cell with tumor cell materials(<span style="color: black;">照片</span><span style="color: black;">源自</span> UCLA)</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">该疫苗<span style="color: black;">经过</span>将在<span style="color: black;">病人</span>手术<span style="color: black;">时期</span>移除的脑肿瘤组织裂解物与从他或她的血液抽取的树突状免疫细胞组合起<span style="color: black;">功效</span>。树突状细胞在实验室中被激活以对抗肿瘤细胞,<span style="color: black;">而后</span>注入<span style="color: black;">病人</span><span style="color: black;">身体</span>,激活T细胞攻击肿瘤。总之,DCVax-L疫苗能够<span style="color: black;">教诲</span>免疫系统与癌症作斗争。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">开发</span><span style="color: black;">机构</span>:生物科技<span style="color: black;">机构</span>Northwest Biotherapeutics</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span><span style="color: black;">周期</span>:III期</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">适应症:新诊多形性胶质母细胞瘤(GBM)</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span>数据:30%<span style="color: black;">病人</span>存活时间超过两年</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">入组临床超过三年的<span style="color: black;">病人</span>中,67例(30%)存活超过30个月,44例(24.2%)存活超过36个月。预计这些<span style="color: black;">病人</span>的中位<span style="color: black;">存活</span>期为46.5至88.2个月。在分析时,参加<span style="color: black;">实验</span>的331名<span style="color: black;">病人</span>中有108名(32.6%)仍然保持存活。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-9e76ea6aca8a597ace2b4792f21d4b16_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">值得<span style="color: black;">重视</span>的是,每一个激活的、装载肿瘤特异性抗原的树突状细胞都<span style="color: black;">拥有</span>很大的乘数效应(multiplier effect),可动员数百个T细胞和其他免疫细胞。<span style="color: black;">因此呢</span>,小剂量的此类树突状细胞就<span style="color: black;">能够</span>动员大规模、持久的免疫应答。<span style="color: black;">一样</span><span style="color: black;">要紧</span>的是,DCVax-L是<span style="color: black;">没</span>毒的。在迄今为止的临床<span style="color: black;">科研</span>中,长达10<span style="color: black;">数年</span>和超过1000个疗程的治疗中<span style="color: black;">无</span><span style="color: black;">显现</span>任何诸如化疗<span style="color: black;">触及</span>的毒性,<span style="color: black;">亦</span><span style="color: black;">无</span><span style="color: black;">出现</span>治疗<span style="color: black;">关联</span>的严重不良事件。</p>4Cimavax-EGF<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">CimaVax是<span style="color: black;">全世界</span>首个注册的用于晚期非小细胞肺癌的治疗性疫苗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">CIMAvax EGF,<span style="color: black;">是由于</span>古巴分子免疫学中心经过25年,穷尽了<span style="color: black;">第1</span>代<span style="color: black;">专家</span>的心血<span style="color: black;">开发</span>出来的,这种治疗型疫苗将肺癌变成慢性病的梦想照进现实!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">初期</span>的<span style="color: black;">实验</span><span style="color: black;">显示</span>,这种治疗<span style="color: black;">办法</span><span style="color: black;">能够</span><span style="color: black;">帮忙</span>60岁以下的晚期肺癌<span style="color: black;">病人</span>平均比未接种疫苗的<span style="color: black;">病人</span>长11个月!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">按照</span>古巴政府官方<span style="color: black;">媒介</span>关于这种疫苗专利的信息,“有两项发明专利,其中一项在直到2028年,<span style="color: black;">包含</span>在欧洲和美国有效,<span style="color: black;">因此呢</span>这80个国家有资格能够<span style="color: black;">营销</span>这种疫苗。国内<span style="color: black;">病人</span>可<span style="color: black;">经过</span><span style="color: black;">全世界</span>肿瘤<span style="color: black;">大夫</span>网医学部向古巴提交申请,接受疫苗治疗。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic1.zhimg.com/80/v2-8cbdbdb08c57b5c6cb729cae2657124c_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">开发</span><span style="color: black;">机构</span>:古巴分子免疫中心</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span><span style="color: black;">周期</span>:III期</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">适应症:Ⅲ,Ⅳ期非小细胞肺癌</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span>数据:五年<span style="color: black;">存活</span>率<span style="color: black;">加强</span>两倍以上!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">发布</span>在国际著名期刊CCR的一项随机的Ⅲ期临床<span style="color: black;">实验</span>中,在年龄<span style="color: black;">少于</span>60岁,EGF水平高的<span style="color: black;">病人</span>中,肺癌疫苗<span style="color: black;">表示</span>出<span style="color: black;">明显</span>的<span style="color: black;">存活</span>获益,五年<span style="color: black;">存活</span>率<span style="color: black;">加强</span>两倍以上!</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic4.zhimg.com/80/v2-b5db1ae37b318883e43f6762ca15d07b_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在一线化疗后4~6周,405名IIIB/IV的非小细胞肺癌<span style="color: black;">病人</span>被随机分配到疫苗组(<span style="color: black;">运用</span>CIMAvax-EGF)和对照组(<span style="color: black;">运用</span>最佳支持治疗)。</p>五年<span style="color: black;">存活</span>率,疫苗组为14.4% ,对照组为7.9%,<span style="color: black;">存活</span>获益<span style="color: black;">拥有</span><span style="color: black;">明显</span><span style="color: black;">道理</span>。而EGF浓度高的患者接种疫苗后,<span style="color: black;">存活</span>获益更大。五年<span style="color: black;">存活</span>率分别为16.62个月和6.22个月。延长了两倍多!<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic1.zhimg.com/80/v2-97ce530d9983e5f6467636888154f5f8_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">还有很<span style="color: black;">要紧</span>的一点,<span style="color: black;">长时间</span>接受疫苗治疗是非常安全的,最<span style="color: black;">平常</span>的副<span style="color: black;">功效</span>是1或2级的注射部位<span style="color: black;">病痛</span>,发烧,呕吐和头痛。这说明肺癌疫苗<span style="color: black;">拥有</span>良好的耐受性,完成诱导期疫苗治疗的<span style="color: black;">病人</span>中位<span style="color: black;">存活</span>期<span style="color: black;">明显</span><span style="color: black;">加强</span>。EGF浓度高的<span style="color: black;">病人</span>更能获益。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2018年9月,世界肺癌大会上,<span style="color: black;">第1</span>次CIMAvax-EGF美国临床<span style="color: black;">实验</span>的初步结果<span style="color: black;">显示</span>,古巴<span style="color: black;">研发</span>的这种免疫疗法安全,耐受性好,值得进一步<span style="color: black;">科研</span>。<span style="color: black;">日前</span>二期临床<span style="color: black;">实验</span>正在顺利进行中。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-6a3916ae33d7453a5af52d6e780b91e6_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>5DCVAC / OvCA<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">DCVAC树突疫苗是一种活性细胞免疫治疗,其<span style="color: black;">运用</span><span style="color: black;">自己</span>树突细胞为<span style="color: black;">每一个</span><span style="color: black;">病人</span>生产和定制,试图诱导针对肿瘤抗原的免疫反应。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">开发</span><span style="color: black;">机构</span>:SOTIO国际生物技术<span style="color: black;">机构</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span><span style="color: black;">周期</span>:II期</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">适应症:晚期复发性卵巢癌</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span>数据:死亡<span style="color: black;">危害</span>降低62%!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2019年第50届妇科肿瘤学会(SGO)年会上,一项二期临床<span style="color: black;">实验</span>SOV02(NCT02107950)<span style="color: black;">最后</span>结果<span style="color: black;">颁布</span>:对复发,铂<span style="color: black;">敏锐</span>,上皮卵巢癌<span style="color: black;">病人</span><span style="color: black;">运用</span>基于树突状细胞的免疫疗法DCVAC / OvCA添加到标准卡铂和吉西他滨<span style="color: black;">方法</span>,<span style="color: black;">能够</span>使晚期复发的卵巢癌<span style="color: black;">病人</span>总<span style="color: black;">存活</span>期(OS)延长一年多,这个数据绝对<span style="color: black;">叫作</span>得上惊艳!</p>DCVAC / OvCa将卵巢癌二线治疗的死亡<span style="color: black;">危害</span>降低了62%。总<span style="color: black;">存活</span>期(OS)显着<span style="color: black;">增多</span>13.4个月。中位数<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>率(mPFS)<span style="color: black;">增多</span>了1.8个月。即将开展<span style="color: black;">全世界</span>三期<span style="color: black;">科研</span>。<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-529c8e17dab48b50e4e5514aacfc1092_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">近期</span>的是卵巢癌的三期树突细胞疫苗(DCVAC / OvCA)<span style="color: black;">实验</span>,将于今年下半年<span style="color: black;">起始</span>。一旦<span style="color: black;">起始</span>招募,<span style="color: black;">全世界</span>肿瘤<span style="color: black;">大夫</span>网医学部将<span style="color: black;">第1</span>时间为<span style="color: black;">大众</span><span style="color: black;">颁布</span>。</p>6Oncovax<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Oncovax疫苗是采用<span style="color: black;">病人</span>自体大肠癌细胞<span style="color: black;">研发</span>的自体肿瘤细胞疫苗,用于在大肠癌切除后对<span style="color: black;">病人</span>进行辅助治疗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">该疫苗是一种由经照射后<span style="color: black;">没</span>增殖和<span style="color: black;">没</span>致瘤性但<span style="color: black;">拥有</span>代谢活性的自体肿瘤细胞与活减毒分枝杆菌——TICE® BCG 结合而成的<span style="color: black;">病人</span>自体肿瘤细胞疫苗。<span style="color: black;">经过</span>从切除的大肠癌组织中提取、纯化肿瘤细胞,再经放射处理,<span style="color: black;">而后</span>接种给<span style="color: black;">病人</span>,针对手术后可能仍存在于<span style="color: black;">病人</span><span style="color: black;">身体</span>的残留癌细胞产生有效和个性化的免疫应答。杀灭残留癌细胞是预防肿瘤复发的<span style="color: black;">重要</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">开发</span><span style="color: black;">机构</span>:美国Vaccinogen 生物技术<span style="color: black;">机构</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span><span style="color: black;">周期</span>:Ⅲ期</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">适应症:结直肠癌术后辅助治疗</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span>数据:延长复发时间,<span style="color: black;">加强</span>五年<span style="color: black;">存活</span>率</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在随机Ⅲ期临床<span style="color: black;">实验</span>中考察了OncoVAX® 对254 例Ⅱ、Ⅲ期结肠癌<span style="color: black;">病人</span>的效果,<span style="color: black;">病人</span>随机分入手术组(对照组,126 例)和手术+ 疫苗组(治疗组,128 例),中位随访期为5.3 年(8 ~ 107个月)。<span style="color: black;">发掘</span>治疗组的复发<span style="color: black;">危害</span><span style="color: black;">明显</span>降低。在<span style="color: black;">病人</span>分期分析中,OncoVAX® 对Ⅲ期结肠癌<span style="color: black;">病人</span><span style="color: black;">没</span><span style="color: black;">明显</span>疗效,但可<span style="color: black;">显著</span>延长Ⅱ期结肠癌<span style="color: black;">病人</span>的<span style="color: black;">没</span>复发期,并且总复发<span style="color: black;">危害</span>率和死亡<span style="color: black;">危害</span>降低。在5.8年的中位随访<span style="color: black;">时期</span>,OncoVAX® <span style="color: black;">显著</span>延长了<span style="color: black;">没</span>复发间期,<span style="color: black;">加强</span>了5 年OS 和<span style="color: black;">没</span>复发<span style="color: black;">存活</span>率等,所有这些<span style="color: black;">实验</span><span style="color: black;">目的</span>都<span style="color: black;">拥有</span>统计学<span style="color: black;">道理</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">迄今,Vaccinogen 生物技术<span style="color: black;">机构</span>已完<span style="color: black;">成为了</span>5 项<span style="color: black;">相关</span>OncoVAX® 对Ⅱ期结肠癌的安全性和有效性的临床<span style="color: black;">实验</span>,<span style="color: black;">包含</span>一项最佳剂量和<span style="color: black;">方法</span>的Ⅲa 期临床<span style="color: black;">实验</span>;就OncoVAX® 与FDA 已达成特殊<span style="color: black;">评定</span>协议(SPA)并被FDA 授予快速通道资格。<span style="color: black;">日前</span>该<span style="color: black;">机构</span>用OncoVAX® 治疗Ⅱ期结肠癌的<span style="color: black;">重要</span>Ⅲ b 期临床<span style="color: black;">实验</span>正在进行中,预计于2020 年7 月初步完成,于2022 年7 月<span style="color: black;">所有</span>完成,届时将提交上市申请,<span style="color: black;">咱们</span>期待这款疫苗<span style="color: black;">早点</span>上市。</p>7SD-101<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2018年1月31日<span style="color: black;">发布</span>在《Science Translational Medicin》上名为“Eradication of spontaneous malignancy by local immunotherapy” 的<span style="color: black;">科研</span>中,斯坦福大学医学院的<span style="color: black;">科研</span>人员成功的将微量的两种免疫刺激剂注射到小鼠的实体瘤中,并有效的消除了小鼠<span style="color: black;">身体</span>所有的癌症痕迹,<span style="color: black;">乃至</span><span style="color: black;">包含</span>远端未经处理的转移病灶!这一<span style="color: black;">科研</span>成果<span style="color: black;">导致</span>了肿瘤学届的轩然大波,临床<span style="color: black;">大夫</span>及肿瘤<span style="color: black;">病人</span>均期待这款癌症疫苗能尽快应用于人体,造福<span style="color: black;">病人</span>!</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">详情查看:震撼肿瘤界,新型“癌症疫苗”可使小鼠癌症<span style="color: black;">所有</span>消退!已进入临床<span style="color: black;">实验</span>!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2018年4月,该疫苗宣布正式开展人体临床<span style="color: black;">实验</span>,招募淋巴瘤<span style="color: black;">病人</span>。<span style="color: black;">倘若</span>它有效,<span style="color: black;">那样</span>在肿瘤手术切除以前<span style="color: black;">能够</span>用这种<span style="color: black;">办法</span>来<span style="color: black;">帮忙</span>预防转移,<span style="color: black;">乃至</span>预防癌症复发。(NCT03410901)</p>8NEO-PV-01<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">NEO-PV-01是 一种个体化新抗原疫苗,是<span style="color: black;">按照</span><span style="color: black;">每一个</span><span style="color: black;">病人</span>的独特突变定制设计和制造的。 其设计<span style="color: black;">包含</span>多达20种新抗原靶向肽,旨在产生抗肿瘤免疫应答,<span style="color: black;">指点</span>T细胞靶向<span style="color: black;">病人</span>肿瘤中的特定癌症新抗原。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌症的一个标志是DNA突变。这些突变中的<span style="color: black;">有些</span><span style="color: black;">引起</span>癌细胞在其表面上呈递<span style="color: black;">叫作</span>为新抗原的肽分子。<span style="color: black;">由于</span>这些新抗原不存在于正常细胞的表面,<span style="color: black;">因此</span>它们是免疫系统识别和攻击的理想靶标。它是从<span style="color: black;">病人</span><span style="color: black;">自己</span>提出来的,<span style="color: black;">因此</span>特异性非常强,并且副<span style="color: black;">功效</span>很小。这<span style="color: black;">寓意</span>着,新抗原<span style="color: black;">关联</span>的免疫疗法是一种真正的个性化疗法。<span style="color: black;">因此呢</span>,鉴定<span style="color: black;">病人</span>特异性免疫原性新抗原是<span style="color: black;">研发</span>此类个体化疫苗的<span style="color: black;">第1</span>步。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">开发</span><span style="color: black;">机构</span>:Neon Therapeutics<span style="color: black;">机构</span><span style="color: black;">开发</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span><span style="color: black;">周期</span>:1b期</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">适应症:黑色素瘤,非小细胞肺癌,膀胱癌</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span>数据:延长<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2019年7月15日 - Neon Therapeutics<span style="color: black;">机构</span>宣布:NEO-PV-01个体化癌症疫苗与OPDIVO®(nivolumab)联合用于晚期或转移性黑色素瘤,吸烟<span style="color: black;">关联</span>非小细胞肺癌(NSCLC)和膀胱癌<span style="color: black;">病人</span>,可<span style="color: black;">明显</span>延长<span style="color: black;">病人</span>的<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">黑色素瘤:在34例转移性黑色素瘤<span style="color: black;">病人</span>的13.4个月中位随访中,尚未达到中位PFS,<span style="color: black;">亦</span><span style="color: black;">便是</span>说,<span style="color: black;">仅有</span>不到一半的<span style="color: black;">病人</span>在13.4个月后<span style="color: black;">显现</span><span style="color: black;">发展</span>;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">非小细胞肺癌:在27例转移性NSCLC<span style="color: black;">病人</span>中,PFS中位数为5.6个月;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">膀胱癌:在21例转移性膀胱癌<span style="color: black;">病人</span>中,PFS中位数为5.6个月。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">而在历史数据中,单药<span style="color: black;">检测</span>点<span style="color: black;">控制</span>剂<span style="color: black;">表示</span>在转移性黑素瘤,非小细胞肺癌和膀胱癌的中位<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期分别为3-7个月,2-4个月和2-3个月。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这是<span style="color: black;">全部</span>新抗原<span style="color: black;">行业</span>的一个<span style="color: black;">要紧</span>里程碑。这些积极的<span style="color: black;">实验</span>结果将支持NEO-PV-01的进一步<span style="color: black;">研发</span>,<span style="color: black;">包含</span>NEO-PV-01在转移性<span style="color: black;">疾患</span>环境中的随机2期<span style="color: black;">实验</span>。</p>9Vaxira<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Racotumomab是CimaVax EGF后在古巴<span style="color: black;">研发</span>的第二种非小细胞肺癌疫苗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Racotumomab(Vaxira®)<span style="color: black;">经过</span>阻断肿瘤生长中存在的NeuGc GM3神经节苷脂的细胞和体液免疫应答起<span style="color: black;">功效</span>,从而延缓其发展并由此<span style="color: black;">增多</span><span style="color: black;">病人</span>的预期寿命并改善生活质量。与传统的化疗和放射治疗癌症不同的是,racotumomab是一种耐受性良好的治疗方式,最<span style="color: black;">平常</span>的副<span style="color: black;">功效</span>是注射部位轻微<span style="color: black;">病痛</span>以及虚弱乏力感。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">经验证,非小细胞肺癌<span style="color: black;">病人</span><span style="color: black;">运用</span>racotumomab(Vaxira)免疫治疗,<span style="color: black;">能够</span><span style="color: black;">做为</span>替代抗原,并使免疫系统活化,以使免疫系统在其表面产生抗癌细胞(表达式为NeuGcGM3)的特定反应杀死癌细胞,这种细胞毒性有别于细胞凋亡,它与温度<span style="color: black;">没</span>关,<span style="color: black;">无</span>染色体固缩等特征。Vaxira是<span style="color: black;">经过</span>诱导癌细胞产生类似肿胀坏死的反应。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌细胞肿胀坏死的过程</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">A 治疗前血清 B-D 三个免疫治疗<span style="color: black;">病人</span>的血清</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">开发</span><span style="color: black;">机构</span>:古巴分子免疫中心</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span><span style="color: black;">周期</span>:II / III期<span style="color: black;">科研</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">适应症:Ⅲ,Ⅳ期非小细胞肺癌</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span>数据:延长总<span style="color: black;">存活</span>期及<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">176位一线化疗后病情稳定的IIIb/IV期非小细胞肺癌<span style="color: black;">病人</span>被按1:1的比例随机分配到racotumomab组(每2周接种一次,每4周再次接种一次)或安慰剂组。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">racotumomab组中位总<span style="color: black;">存活</span>期为8.23个月,安慰剂组中位总<span style="color: black;">存活</span>期为6.80个月;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">racotumomab组中位<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期为5.33个月,安慰剂组中位<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期为3.90个月。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">治疗组和对照组<span style="color: black;">病人</span>总<span style="color: black;">存活</span>期(OS)的km曲线</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="data:image/svg+xml;utf8," style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">治疗组和对照组<span style="color: black;">病人</span><span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期(PFS)的km曲线</p>10树突疫苗<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">日前</span>树突状细胞肿瘤疫苗正在被<span style="color: black;">快速</span>、广泛的<span style="color: black;">科研</span> ,并且已在动物实验和<span style="color: black;">初期</span>的临床实验中取得了<span style="color: black;">特别有</span><span style="color: black;">道理</span>的结果。这些<span style="color: black;">科研</span>结果<span style="color: black;">显示</span>: 树突状细胞肿瘤疫苗不仅能够诱发针对原发肿瘤的免疫应答 , <span style="color: black;">况且</span><span style="color: black;">亦</span>能够诱发针对转移肿瘤的免疫应答 , 并且 CD4 + 、 CD8 + T 淋巴细胞和自然杀伤细胞 ( natur e kille r cells, N Ks)都参与抗肿瘤免疫应答。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">树突细胞可<span style="color: black;">经过</span><span style="color: black;">各样</span>方式用于癌症疫苗接种,<span style="color: black;">包含</span>:</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1)<span style="color: black;">身体</span>树突细胞<span style="color: black;">捕捉</span>的非靶向肽/蛋白和基于核酸的疫苗,</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2)直接与抗树突抗体偶联的抗原<span style="color: black;">构成</span>的疫苗,</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">3 )由体外产生的负载抗原的树突<span style="color: black;">构成</span>的疫苗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">一项新的小型新<span style="color: black;">科研</span><span style="color: black;">显示</span>,一种直接注射到单个肿瘤中的新型癌症“疫苗”<span style="color: black;">能够</span>激活免疫系统 攻击全身的癌细胞。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这项<span style="color: black;">科研</span><span style="color: black;">是由于</span>纽约西奈山伊坎医学院淋巴瘤免疫治疗项目<span style="color: black;">专家</span>Joshua Brody博士领导的,他说,“将疫苗注射到一个肿瘤后(原位疫苗接种),<span style="color: black;">咱们</span>看到<span style="color: black;">全部</span>身<span style="color: black;">身体</span>的肿瘤消失”。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这项重磅的<span style="color: black;">科研</span>4月8日<span style="color: black;">发布</span>在国际顶级期刊“ Nature medicine”杂志上。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在抗癌疫苗的治疗下,11名<span style="color: black;">病人</span>中有8名取得了病情缓解,其中完全缓解的<span style="color: black;">病人</span>有2名。1名达到完全缓解的<span style="color: black;">病人</span>,<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期<span style="color: black;">已然</span>接近4年!这些积极结果,<span style="color: black;">亦</span>让<span style="color: black;">科研</span>人员们充满<span style="color: black;">自信心</span>,现在该治疗<span style="color: black;">办法</span><span style="color: black;">亦</span>正在乳腺癌和头颈癌<span style="color: black;">病人</span>中进行检测。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">由于</span>DC是最有效的抗原呈递细胞,<span style="color: black;">因此呢</span>,利用它们的多样性可能产生改进的治疗性疫苗。树突细胞疫苗在各个癌症中取得了令人振奋的<span style="color: black;">科研</span>数据,想<span style="color: black;">认识</span>临床<span style="color: black;">实验</span><span style="color: black;">仔细</span>招募信息的<span style="color: black;">病人</span>可致电<span style="color: black;">全世界</span>肿瘤<span style="color: black;">大夫</span>网医学部进行初步<span style="color: black;">评定</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌症疫苗将打开攻破癌症的<span style="color: black;">前门</span>!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌细胞表面存在特殊的蛋白质,<span style="color: black;">经过</span>靶向这些蛋白质,免疫系统<span style="color: black;">能够</span>特异性地消除癌细胞,<span style="color: black;">同期</span>不<span style="color: black;">损伤</span>正常的细胞。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">将来</span>的新抗原疫苗<span style="color: black;">实验</span>将招募<span style="color: black;">更加多</span>的晚期<span style="color: black;">病人</span>测试疫苗的疗效,利用预测来<span style="color: black;">加强</span>有效的新抗原和<span style="color: black;">检测</span>点<span style="color: black;">控制</span>剂和其他免疫疗法协同<span style="color: black;">实验</span>的抗原呈递的改进<span style="color: black;">办法</span>,”<span style="color: black;">专家</span>们说。“<span style="color: black;">倘若</span>成功,在随后的<span style="color: black;">实验</span>中,个体化疫苗将被用于各类癌症,<span style="color: black;">持有</span>足够数量的新抗原接种疫苗<span style="color: black;">拥有</span>巨大<span style="color: black;">潜能</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">咱们</span>期待,从<span style="color: black;">此刻</span>起20年后,人类能够接种疫苗来预防癌症,战胜癌症,相信这一天离<span style="color: black;">咱们</span>不远了!</p>
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