颠覆认知!新科研首次证明:没基因突变亦会显现癌症【附中国抗肿瘤药物行业市场规模预测】
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q2.itc.cn/q_70/images03/20240425/38dae71a9d254a419788418ed9cbdd12.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图源:摄图网</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">癌症是<span style="color: black;">引起</span>人类死亡的<span style="color: black;">要紧</span>病因。</strong>几十年来,<span style="color: black;">专家</span>们都在寻找<span style="color: black;">有些</span><span style="color: black;">要紧</span>的基因,<span style="color: black;">例如</span>抑癌基因或原癌基因,试图查明癌症<span style="color: black;">出现</span>机制。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">近期</span>,《自然》最新<span style="color: black;">科研</span>将颠覆<span style="color: black;">咱们</span>的认知</strong>。来自法国国家科学<span style="color: black;">科研</span>中心(CNRS)和蒙彼利埃大学的<span style="color: black;">专家</span><span style="color: black;">发掘</span>,即便驱动基因<span style="color: black;">无</span><span style="color: black;">出现</span>突变——即DNA序列上的变异,仅仅表观遗传上的变异<span style="color: black;">亦</span>足以<span style="color: black;">引起</span>细胞癌变。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">“这是<span style="color: black;">专家</span>们<span style="color: black;">第1</span>次证明基因突变并不是癌症发病的必要<span style="color: black;">前提</span></strong><strong style="color: blue;">。”</strong><span style="color: black;">科研</span>作者在<span style="color: black;">资讯</span>稿中指出,“这一<span style="color: black;">发掘</span>迫使<span style="color: black;">咱们</span>重新<span style="color: black;">思虑</span>30<span style="color: black;">数年</span>来<span style="color: black;">始终</span>认为癌症<span style="color: black;">重点</span>是基因<span style="color: black;">疾患</span>的理论。”</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>人员重点关注了能够改变基因活性的一类表观遗传因子——<strong style="color: blue;">Polycomb(多梳蛋白)</strong>。<span style="color: black;">经过</span>实验据得知,在<span style="color: black;">无</span>驱动基因突变的<span style="color: black;">状况</span>下,Polycomb蛋白的可逆损耗<span style="color: black;">能够</span>诱发癌症。”论文摘要总结,“这<span style="color: black;">显示</span>肿瘤<span style="color: black;">能够</span><span style="color: black;">经过</span>表观遗传失调<span style="color: black;">诱发</span>的细胞命运改变而<span style="color: black;">显现</span>。”</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">基于果蝇实验的结果,<span style="color: black;">科研</span>人员推测在哺乳动物身上,表观遗传事件<span style="color: black;">亦</span>可能在癌症的<span style="color: black;">初期</span><span style="color: black;">出现</span><span style="color: black;">周期</span>或<span style="color: black;">发展</span>过程中发挥<span style="color: black;">要紧</span><span style="color: black;">功效</span>。为此,<span style="color: black;">科研</span>人员<span style="color: black;">已然</span><span style="color: black;">起始</span>在<span style="color: black;">触及</span>不同癌症类型的<span style="color: black;">病人</span>数据库中展开调查。期待新<span style="color: black;">发掘</span>为癌症治疗开辟新的途径。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">全世界</span>癌症新发及死亡病例数<span style="color: black;">连续</span><span style="color: black;">提升</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">按照</span>世界卫生组织(WHO)下属的国际癌症<span style="color: black;">科研</span><span style="color: black;">公司</span>(IARC)<span style="color: black;">颁布</span>的信息,<strong style="color: blue;"><span style="color: black;">全世界</span>癌症新发病例数<span style="color: black;">连续</span><span style="color: black;">提升</span>,从2018年的1807.9万例上涨到2022年的1996.5万例。</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">随着癌症新发病例数<span style="color: black;">提升</span>,<span style="color: black;">全世界</span>癌症死亡病例数<span style="color: black;">亦</span>呈<span style="color: black;">提升</span>趋势,但增速<span style="color: black;">小于</span>癌症新发病例数增速。<strong style="color: blue;">2022年,<span style="color: black;">全世界</span>癌症死亡病例数为973.7万例。</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q0.itc.cn/q_70/images03/20240425/febdfb9d27524cce82aa1a766b32f3a2.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">中国各类癌症新发病例数量占比<span style="color: black;">状况</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2016-2022年,中国癌症新发病例数呈现逐年增长趋势。2022年,中国癌症新发病例数达到了482.5万人,同比增长2.9%。<strong style="color: blue;">初步估计,2023年中国癌症新发病例数超490万人。</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">从不同癌症新发病例数量来看,<strong style="color: blue;">肺癌</strong>新发病例数为106.06万例,占比约22%,在中国癌症中占据首位,<span style="color: black;">作为</span>最<span style="color: black;">平常</span>的癌症类型。其后依次是结直肠癌、甲状腺癌、肝癌和胃癌。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q7.itc.cn/q_70/images03/20240425/6cd658bc74f04adba5600b888750dffb.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">全世界</span>抗肿瘤<span style="color: black;">药品</span><span style="color: black;">归类</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">按照</span>药智数据披露的“2023年<span style="color: black;">全世界</span>抗肿瘤<span style="color: black;">药品</span><span style="color: black;">营销</span>额TOP20”榜单,2023年<span style="color: black;">全世界</span>抗肿瘤<span style="color: black;">药品</span><span style="color: black;">制品</span>需求中,靶向<span style="color: black;">药品</span><span style="color: black;">已然</span><span style="color: black;">作为</span>主流,TOP20<span style="color: black;">营销</span>额<span style="color: black;">药物</span><span style="color: black;">所有</span>是靶向<span style="color: black;">药品</span>。从<span style="color: black;">详细</span><span style="color: black;">药品</span>类型来看,Top20中有11个小分子靶向<span style="color: black;">药品</span>、7个单克隆抗体和2个抗体偶联<span style="color: black;">药品</span>(ADC)。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q2.itc.cn/q_70/images03/20240425/6141ddc639364bb6a7947d25ac4ba0a4.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">中国抗肿瘤<span style="color: black;">药品</span>行业市场规模预测</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">随着医学技术的飞速发展和公众癌症预防<span style="color: black;">认识</span>的<span style="color: black;">加强</span>,癌症检出率<span style="color: black;">亦</span>相应<span style="color: black;">加强</span>。老龄化及公众癌症预防<span style="color: black;">认识</span><span style="color: black;">加强</span>推动抗肿瘤<span style="color: black;">药品</span>市场规模上涨。前瞻预计,到2029年,中国抗肿瘤<span style="color: black;">药品</span>行业市场规模有望达到5590亿元,2024-2029年复合增长率约19%。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q6.itc.cn/q_70/images03/20240425/177a690721a84123ad4813ee607b4c0e.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">日前</span>,<span style="color: black;">经过</span>企查猫及前瞻智慧招商系统数据<strong style="color: blue;">,国内抗肿瘤药行业上市<span style="color: black;">公司</span>大多布局华东、华中、华北等地区,<span style="color: black;">少许</span>龙头<span style="color: black;">公司</span>布局海内外。</strong>在<span style="color: black;">制品</span>布局方面,抗肿瘤药<span style="color: black;">表率</span><span style="color: black;">公司</span>依托现有<span style="color: black;">制品</span>的市场<span style="color: black;">优良</span>,加快技术<span style="color: black;">开发</span>,进行<span style="color: black;">制品</span>升级。此外,龙头<span style="color: black;">公司</span>如恒瑞医药,<span style="color: black;">经过</span>工程建设,实现扩产计划。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">另外</span>,专家强调,<span style="color: black;">按照</span>临床案例数据<span style="color: black;">表示</span>,70%被确诊的肺癌<span style="color: black;">处在</span>III期,<strong style="color: blue;">但<span style="color: black;">倘若</span><span style="color: black;">经过</span>筛查,能够在<span style="color: black;">初期</span><span style="color: black;">周期</span>识别出癌变可能性,将为<span style="color: black;">病人</span>带来<span style="color: black;">更加多</span>的治疗<span style="color: black;">选取</span>和更有<span style="color: black;">期盼</span>治愈。 </strong></p>
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