不化疗,不放疗,晚期肺癌病人找到了延长生命的新办法!
<h2 style="color: black; text-align: left; margin-bottom: 10px;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_gif/CwkERAMhICxkfWKjTWhz17Bah1MXChdQrN1HVaMUh898UbPzQ3RasTaP7oWh7fazQHLhXulgEic5Jjd1gic28BEQ/640?wx_fmt=gif&tp=webp&wxfrom=5&wx_lazy=1" style="width: 50%; margin-bottom: 20px;"></span></h2>确诊晚期肺癌,<span style="color: black;">存活</span>期不到一年<span style="color: black;">2016年,住在加拿大里贾纳Judy Bryden和丈夫带着女儿<span style="color: black;">一块</span>去国外旅行,当时Bryden有些感冒的症状但<span style="color: black;">大众</span>都<span style="color: black;">无</span>太<span style="color: black;">留意</span>,以为只是对气候不太适应。</span><span style="color: black;">回家后,看了家庭<span style="color: black;">大夫</span>,<span style="color: black;">亦</span>吃了药,然而症状<span style="color: black;">无</span>任何改善,丈夫和女儿带她去大医院进行了全面的<span style="color: black;">检测</span>。</span>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_jpg/CwkERAMhICwZpLFpicwwUpfiboHX0Qic7gQEN4Z30a8n48xu58eSr29WMjmsWO83R0dNyrbVCUxCDiburoNKVpEmbA/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p><span style="color: black;">胸部扫描结果出来后,得到的诊断对<span style="color: black;">整家</span>是毁灭性的:</span><span style="color: black;">晚期肺癌,并且<span style="color: black;">已然</span><span style="color: black;">没</span>法手术。</span><span style="color: black;">2016年11月,Bryden<span style="color: black;">起始</span>接受化疗,她说,化疗差点要了她的命,副<span style="color: black;">功效</span>带来的痛苦远大于癌症带来的,并且化疗并<span style="color: black;">无</span>起到太大效果,病情还在<span style="color: black;">发展</span>。</span><span style="color: black;">在<span style="color: black;">大夫</span>的<span style="color: black;">意见</span>下,她做了基因检测,<span style="color: black;">然则</span><span style="color: black;">无</span>找到任何可用的<span style="color: black;">药品</span>。</span><span style="color: black;">于是她只能<span style="color: black;">选取</span>姑息性的放疗,幸运的是,放疗暂时<span style="color: black;">掌控</span>住了病情,但<span style="color: black;">大夫</span>说<span style="color: black;">由于</span>她的癌症太晚期,<span style="color: black;">因此</span><span style="color: black;">存活</span>期仅在一年<span style="color: black;">上下</span>。</span>不想放疗,不想化疗,找到延续生命的新<span style="color: black;">办法</span><span style="color: black;">“当<span style="color: black;">她们</span>告诉我我有一年的生活时,我说我要证明<span style="color: black;">她们</span>错了。</span><span style="color: black;">”Bryden说。</span><span style="color: black;"><span style="color: black;">第1</span>轮化疗结束后,Bryden拒绝了第二次化疗,他的丈夫<span style="color: black;">亦</span>不愿看着妻子承受如此巨大的痛苦,但<span style="color: black;">亦</span>不想就此放弃,于是他四处寻找能<span style="color: black;">尽可能</span>延长妻子生命的<span style="color: black;">办法</span>,<span style="color: black;">最终</span>,他在网上看到一种专门治疗晚期肺癌的疫苗,叫做Cimavax,<span style="color: black;">是由于</span>古巴分子免疫中心经过25年<span style="color: black;">开发</span>成功的,<span style="color: black;">已然</span>在古巴上市<span style="color: black;">运用</span><span style="color: black;">数年</span>。</span><span style="color: black;">又在网上查阅了<span style="color: black;">海量</span>的信息和文献,咨询了<span style="color: black;">有些</span><span style="color: black;">大夫</span><span style="color: black;">伴侣</span>后,<span style="color: black;">认识</span>到这款肺癌疫苗的与众不同之处:</span><span style="color: black;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">首要</span>Cimavax-EGF与靶向药的抗癌原理不同。</span></strong></span><span style="color: black;">它是一种基于生物技术的疫苗,它治疗晚期肺癌完全是生物治疗的方式:</span><span style="color: black;">它有助于身体产生自己的免疫系统,从而遏制癌症并阻止其增长。</span><span style="color: black;">简单<span style="color: black;">来讲</span>,正常细胞和癌细胞生长都<span style="color: black;">必须</span>一种<span style="color: black;">要紧</span>的蛋白质--表皮生长因子(EGF),肺癌细胞生长<span style="color: black;">亦</span><span style="color: black;">必须</span><span style="color: black;">海量</span>的表皮生长因子,这相当于是细胞生长的养料,当注射Cimavax肺癌疫苗后,会刺激机体产生<span style="color: black;">海量</span>的抗体,<span style="color: black;">这般</span>,<span style="color: black;">身体</span>的表皮生长因子就会与抗体特异性的结合而<span style="color: black;">海量</span>减少,<span style="color: black;">这般</span>一来,癌细胞的养料就被清除了,<span style="color: black;">此时</span>,正常细胞<span style="color: black;">能够</span><span style="color: black;">经过</span>其他途径<span style="color: black;">得到</span>生长的养料,而依赖表皮生长因子的肺癌细胞只能被活活饿死。</span><span style="color: black;"><span style="color: black;">日前</span>肺癌<span style="color: black;">病人</span>广泛<span style="color: black;">运用</span>的靶向药例如特罗凯等,其<span style="color: black;">经过</span><span style="color: black;">掌控</span>肿瘤生长激素延长<span style="color: black;">病人</span>寿命,与Cimavax类似。</span><span style="color: black;">然而,靶向药大都非常昂贵,<span style="color: black;">况且</span>有<span style="color: black;">必定</span>的副<span style="color: black;">功效</span>,而Cimavax<span style="color: black;">因为</span>其非常低的副<span style="color: black;">功效</span>和<span style="color: black;">优惠</span>的价格而使<span style="color: black;">更加多</span>晚期癌症<span style="color: black;">病人</span>受益(据<span style="color: black;">认识</span>古巴政府每次<span style="color: black;">药品</span>的<span style="color: black;">花费</span>为一美元<span style="color: black;">上下</span>,<span style="color: black;">此刻</span>古巴本土居民免费接收疫苗治疗)。</span><span style="color: black;"><strong style="color: blue;"><span style="color: black;">其次,这款疫苗有着自己独特的适应症,专门针<span style="color: black;">针对</span>像Bryden<span style="color: black;">这般</span>的晚期非小细胞肺癌<span style="color: black;">病人</span>。</span></strong></span><span style="color: black;"><span style="color: black;">科研</span>人员确信其中五分之一的<span style="color: black;">病人</span><span style="color: black;">得到</span>成功。大部分肿瘤消失,有一部分<span style="color: black;">病人</span>肿瘤完全消失!23%的<span style="color: black;">病人</span><span style="color: black;">存活</span>期超过5年。虽然是晚期肺癌。但接受疫苗治疗后,<span style="color: black;">有些</span><span style="color: black;">病人</span><span style="color: black;">能够</span>正常工作,生活,<span style="color: black;">况且</span><span style="color: black;">她们</span>的生活质量很高。</span><span style="color: black;"><strong style="color: blue;"><span style="color: black;">最后,这款疫苗并不是晚期肺癌的奇迹<span style="color: black;">处理</span><span style="color: black;">方法</span>,<span style="color: black;">没</span>法治愈肺癌。</span></strong></span><span style="color: black;">Bryden看到的一项大型数据<span style="color: black;">表示</span>,在古巴进行的III期<span style="color: black;">实验</span>中,A组有270名古巴<span style="color: black;">病人</span>接种了CIMAvax疫苗,B组175名<span style="color: black;">病人</span>未接种。所有人都<span style="color: black;">身患</span>晚期小细胞肺癌,首选化疗为<span style="color: black;">第1</span>线<span style="color: black;">方法</span>,病情基本稳定。五年<span style="color: black;">存活</span>期分别为16.62个月和6.22个月,延长了两倍多,<span style="color: black;">拥有</span><span style="color: black;">明显</span>的<span style="color: black;">存活</span>获益。但大<span style="color: black;">都数</span>非小细胞肺癌疫苗<span style="color: black;">运用</span>者被证明<span style="color: black;">能够</span>延长数月,而不是几年。并且并不是对<span style="color: black;">每一个</span><span style="color: black;">病人</span>都有效,在<span style="color: black;">实验</span>中,约20%的<span style="color: black;">病人</span><span style="color: black;">无</span>响应。<span style="color: black;">因此呢</span>非小细胞肺癌疫苗cimavax<span style="color: black;">亦</span>不是肺癌的奇迹<span style="color: black;">处理</span><span style="color: black;">方法</span>。它不会挽救终末期肺癌<span style="color: black;">病人</span>的生命。它只能延长和略微改善<span style="color: black;">存活</span>期。</span><span style="color: black;">但值得肯定的是,在古巴,与未接受标准化疗联合用药的肺癌<span style="color: black;">病人</span>相比,许多接受CIMAvax治疗的<span style="color: black;">病人</span>寿命更长,生活质量更高,副<span style="color: black;">功效</span>最小。</span><span style="color: black;">2017年1月,在<span style="color: black;">认识</span>清楚Cimavax的利<span style="color: black;">坏处</span>后,Bryden和丈夫决定前往古巴进行尝试,<span style="color: black;">她们</span>都很清楚晚期肺癌是<span style="color: black;">没</span>法治愈的,只要有<span style="color: black;">办法</span><span style="color: black;">尽可能</span>延长<span style="color: black;">存活</span>期,相信随着抗癌药的快速<span style="color: black;">开发</span>,肺癌迟早会有一天变为慢性病。</span><span style="color: black;">而恰巧在<span style="color: black;">此时</span>,FDA<span style="color: black;">亦</span>正式<span style="color: black;">准许</span>Cima Vax疫苗在纽约州布法罗市罗斯威尔帕克癌症<span style="color: black;">科研</span>所对<span style="color: black;">病人</span>进行了临床<span style="color: black;">实验</span>。这<span style="color: black;">亦</span>让Bryden和丈夫坚定了治疗的<span style="color: black;">自信心</span>,<span style="color: black;">由于</span><span style="color: black;">倘若</span>这款<span style="color: black;">药品</span><span style="color: black;">无</span>效果,美国<span style="color: black;">做为</span>抗癌<span style="color: black;">药品</span><span style="color: black;">开发</span>和上市最多的国家,<span style="color: black;">亦</span>不会和古巴破冰合作,从它怒怼了50年的老邻居那引进<span style="color: black;">药品</span>。</span>重回正常生活,感谢肺癌疫苗让我还活着<span style="color: black;">在丈夫和女儿的陪同下,Brydens于2017年3月前往古巴的哈瓦那,接受疫苗治疗的地点是拉普拉德拉国际疗养中心,这是一家医疗水平和声望都很高的医院,之前委内瑞拉的前总统患癌时,<span style="color: black;">亦</span>是来<span style="color: black;">这儿</span>接受治疗的。它<span style="color: black;">重点</span>面向外国人,像Brydens<span style="color: black;">这般</span>的国际付费病人,<span style="color: black;">大夫</span>对<span style="color: black;">病人</span>的态度都非常友好。与其说La Pradera是一家医院,它感觉更像一家热带酒店,游泳池,棕榈树和开放式走廊。</span><img src="https://mmbiz.qpic.cn/mmbiz_jpg/CwkERAMhICycskn4PArhEgiba7NbLMpVarLib08FsGCUZCAwEZH2X8jCUw7gDs87xM4ZwAMDTSJVEwFJD3WH0e0Q/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><img src="https://mmbiz.qpic.cn/mmbiz_jpg/CwkERAMhICycskn4PArhEgiba7NbLMpVawslp3NodthH5pwZOkhKQ4Z82ticjumKWiblA0KXMnVUdDBC7yTNOGDeg/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><img src="https://mmbiz.qpic.cn/mmbiz_jpg/CwkERAMhICwMD67HYw76tdGnqXJ2ujoliatSQ0ibrSWTiauOE2HLGzdWsc9b9kVOv84vU7wn861ZoQAt2N0ORU8Fg/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><span style="color: black;"><span style="color: black;">她们</span>在哈瓦那停留了六天,这次旅行,加上将非小细胞肺癌疫苗(一年药量)带回加拿大,总共<span style="color: black;">花费</span>大约14,500美元。</span><img src="https://mmbiz.qpic.cn/mmbiz_jpg/CwkERAMhICycskn4PArhEgiba7NbLMpVakNqzZ3AzibcqRLkgPdRllDGenQlXf5xXEf80yTL5mklYnicJ7BL1JMxg/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><img src="https://mmbiz.qpic.cn/mmbiz_jpg/CwkERAMhICycskn4PArhEgiba7NbLMpVa190VibONnkL92CxOc5H5nQHica6UbONnF9Q68qPeCpSBO7VCGew33iaXg/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><span style="color: black;">直到今年2月,Bryden的CT扫描未<span style="color: black;">发掘</span>任何癌症迹象。</span><span style="color: black;">“我<span style="color: black;">期盼</span><span style="color: black;">更加多</span>像我<span style="color: black;">这般</span>的晚期肺癌<span style="color: black;">病人</span><span style="color: black;">晓得</span>古巴<span style="color: black;">已然</span>有了治疗肺癌的疫苗,并且每月的<span style="color: black;">花费</span>是1000美元,这很值得。”Bryden说。</span><span style="color: black;">布莱登说,<span style="color: black;">针对</span>她<span style="color: black;">这般</span>的晚期<span style="color: black;">病人</span>,不管是接受靶向治疗还是免疫治疗,都有严重的副<span style="color: black;">功效</span>,并且一段时间后都会产生耐药性,一旦<span style="color: black;">出现</span>耐药,病情<span style="color: black;">发展</span>,治疗将变的<span style="color: black;">非常</span>棘手。而古巴的疫苗<span style="color: black;">能够</span>在标准治疗后<span style="color: black;">运用</span>,<span style="color: black;">掌控</span>病情,<span style="color: black;">尽可能</span>延长<span style="color: black;">存活</span>期。</span><span style="color: black;">她<span style="color: black;">期盼</span>自己的故事鼓励其他人自己尝试治疗。<span style="color: black;">日前</span>她还在<span style="color: black;">保持</span>接受疫苗的治疗来<span style="color: black;">掌控</span>病情。</span><span style="color: black;">加拿大卫生部<span style="color: black;">暗示</span>,加拿大医疗<span style="color: black;">公司</span>不<span style="color: black;">供给</span>CIMAvax,<span style="color: black;">由于</span>还<span style="color: black;">无</span>提交疫苗<span style="color: black;">准许</span>申请。“加拿大卫生部发言人Renelle Briand说:“古巴肺癌疫苗生产<span style="color: black;">机构</span>会向加拿大卫生部提交申请,以便<span style="color: black;">她们</span>的<span style="color: black;">制品</span><span style="color: black;">能够</span>在加拿大卫生<span style="color: black;">分部</span><span style="color: black;">得到</span><span style="color: black;">准许</span>进入市场。”</span><span style="color: black;">美国食品和<span style="color: black;">药品</span>管理局于2016年<span style="color: black;">准许</span>了CIMAvax在美国的临床<span style="color: black;">实验</span>。该<span style="color: black;">实验</span>预计将招募多达90名<span style="color: black;">病人</span>,并<span style="color: black;">必须</span>三年的时间<span style="color: black;">才可</span>完成。<span style="color: black;">非常多</span>晚期<span style="color: black;">病人</span><span style="color: black;">已然</span>等不及了。</span><span style="color: black;">2018年9月,世界肺癌大会上,<span style="color: black;">第1</span>次CIMAvax-EGF美国临床<span style="color: black;">实验</span>的初步结果<span style="color: black;">显示</span>,古巴<span style="color: black;">研发</span>的这种免疫疗法安全,耐受性好,值得进一步<span style="color: black;">科研</span>。<span style="color: black;">日前</span>二期临床<span style="color: black;">实验</span>正在顺利进行中。</span><span style="color: black;">从古巴到纽约,<span style="color: black;">咱们</span>很高兴能够看到世界范围内,针对肺癌的治疗有一些创新的思路和<span style="color: black;">方向</span>,关于古巴肺癌疫苗,从<span style="color: black;">日前</span>看是有<span style="color: black;">必定</span>临床效果的,但绝不是什么“神药”,<span style="color: black;">咱们</span>不要轻易否定,更<span style="color: black;">不可</span>过分迷信,毕竟在国内还未<span style="color: black;">获准</span>,但<span style="color: black;">能够</span>保持关注。</span><span style="color: black;"><strong style="color: blue;"><span 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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">肺癌</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">胃癌</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">结直肠癌</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">肝癌</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">胰腺癌</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">乳腺癌</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">食管癌</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">肉瘤</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">儿童肿瘤</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">泌尿系统肿瘤</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">妇</span></strong></span></a><strong style="color: blue;">科肿瘤</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">其他肿瘤</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">PD-1</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">基因检测</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">靶向治疗</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">质子治疗</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">免疫治疗</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">电场治疗</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">专家会诊</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">出国<span style="color: black;">看病</span></span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_jpg/CwkERAMhICygicnpDHJezcZACibhKgGiaYNfrPUr81ToPaybdzdacvsvJwruMDAlvnDhtbTTDSsnQhu6uyTjbiaXbg/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
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