新科研：破解靶向药耐药困难，在癌细胞进化前消灭它！
<img src="https://mmbiz.qpic.cn/mmbiz_jpg/49iaFZeibYsYfM4h7pcba8wZdkFqpUib0YCnyOLia9bZnKp2QrzvdVNfyVwNL7cpoEQ2n8mmXDAGpz4VCWwbW4O38g/640?wx_fmt=jpeg&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;"><span style="color: black;">本文由盛诺一家原创编译，转载需经授权</span><p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">导读</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">非常多</span></span><span style="color: black;">肺癌<span style="color: black;">病人</span></span><span style="color: black;">会</span><span style="color: black;"><span style="color: black;">经过</span>基因检测检出携带有</span><span style="color: black;">EGFR突变</span><span style="color: black;">，而这些<span style="color: black;">病人</span></span><span style="color: black;"><span style="color: black;">常常</span></span><span style="color: black;"><span style="color: black;">能够</span></span><span style="color: black;"><span style="color: black;">运用</span></span><span style="color: black;">EGFR靶向药<span style="color: black;">掌控</span></span><span style="color: black;">肿瘤。虽然靶向药效果良好且副<span style="color: black;">功效</span></span><span style="color: black;"><span style="color: black;">少于</span>化疗</span><span style="color: black;">，但不可避免的会<span style="color: black;">显现</span>耐药，之后靶向药就没办法再起<span style="color: black;">功效</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">近期，</span><span style="color: black;"><span style="color: black;">全世界</span></span><span style="color: black;">知名癌症专科医院</span><span style="color: black;">MD安德森癌症</span><span style="color: black;">中心的<span style="color: black;">科研</span>人员确定了一个专门针对</span><span style="color: black;">EGFR突变</span><span style="color: black;">的非小细胞肺癌（</span><span style="color: black;">NSCLC</span><span style="color: black;">）</span><span style="color: black;">耐药</span><span style="color: black;">癌细胞的治疗新靶点</span><span style="color: black;">——CD70</span><span style="color: black;">，据<span style="color: black;">叫作</span></span><span style="color: black;">，</span><span style="color: black;">治疗</span><span style="color: black;">该靶点<span style="color: black;">能够</span>消除</span><span style="color: black;">EGFR靶向治疗</span><span style="color: black;">后残留的耐药细胞。该<span style="color: black;">科研</span><span style="color: black;">发布</span>在</span><span style="color: black;">了</span><span style="color: black;">《</span><span style="color: black;">癌细胞</span><span style="color: black;">》</span><span style="color: black;">上</span><span style="color: black;">。</span></p><img src="https://mmbiz.qpic.cn/mmbiz_jpg/49iaFZeibYsYcBgfKjibprtTZXAAAicajxADyA2fsFklEV1Kk7zB5KoMot8GvTNW5mTfIyYsSGBia5DMup488hkIEpQ/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><span style="color: black;"><span style="color: black;">源自</span>：</span><span style="color: black;">摄图网</span><strong style="color: blue;"><span style="color: black;">详情请看下文</span></strong><span style="color: black;">这项临床前<span style="color: black;">科研</span>由Monique Nilsson博士和John Heymach博士（胸腔/头颈内科肿瘤学主席）领导。<span style="color: black;">科研</span>人员<span style="color: black;">发掘</span>，CD70是一种<span style="color: black;">一般</span><span style="color: black;">能够</span>在免疫细胞上<span style="color: black;">发掘</span>的细胞表面蛋白，在EGFR靶向药治疗后残留的癌细胞中高度过表达。</span><span style="color: black;"><span style="color: black;">科研</span>人员证实，在实验室模型中，CD70<span style="color: black;">能够</span>有效地<span style="color: black;">做为</span>靶点，用于前沿的抗体偶联<span style="color: black;">药品</span>（ADC<span style="color: black;">药品</span>）或细胞免疫疗法。</span><span style="color: black;">“靶向治疗后残留的癌细胞本质上是一个储存库，而<span style="color: black;">将来</span><span style="color: black;">拥有</span>耐药性的癌细胞蕞终会在里面进化而出，<span style="color: black;">持续</span>生长，”Heymach说。“这些<span style="color: black;">发掘</span>奠定了<span style="color: black;">基本</span>，<span style="color: black;">咱们</span><span style="color: black;">能够</span>针对该靶点<span style="color: black;">供给</span>有效疗法，<span style="color: black;">运用</span>靶向CD70的<span style="color: black;">药品</span>来消除靶向治疗后的残留癌细胞。”</span><span style="color: black;">大约10-15%的非小细胞肺癌<span style="color: black;">病人</span>携带有EGFR突变。虽然用EGFR靶向药治疗（如奥希替尼）可有效杀死大<span style="color: black;">都数</span>癌细胞，但<span style="color: black;">少许</span>耐药癌细胞仍然存在。这些细胞<span style="color: black;">能够</span><span style="color: black;">长期</span>保持休眠，<span style="color: black;">乃至</span><span style="color: black;">没法</span>被<span style="color: black;">发掘</span>，但它们蕞终会悄悄生长、转移。</span><span style="color: black;">癌细胞<span style="color: black;">能够</span><span style="color: black;">经过</span>多种机制对EGFR靶向药产生抗性，<span style="color: black;">例如</span><span style="color: black;">包含</span>上皮到间充质转化（EMT）。经过EMT的肿瘤会对大<span style="color: black;">都数</span>已知<span style="color: black;">药品</span><span style="color: black;">拥有</span>耐药性，<span style="color: black;">引起</span>肿瘤复发<span style="color: black;">病人</span>的预后不良，<span style="color: black;">因此呢</span>，<span style="color: black;">病人</span><span style="color: black;">针对</span><span style="color: black;">处理</span>耐药问题的<span style="color: black;">需要</span>，远未得到满足。</span><span style="color: black;">进一步<span style="color: black;">科研</span><span style="color: black;">显示</span>，CD70的过表达在靶向治疗后残留的耐药细胞中<span style="color: black;">显著</span>上调。</span><span style="color: black;">“<span style="color: black;">发掘</span>CD70在肺癌细胞耐药性进化<span style="color: black;">初期</span><span style="color: black;">周期</span>上调，真的很令人鼓舞，<span style="color: black;">由于</span>这<span style="color: black;">寓意</span>着<span style="color: black;">咱们</span><span style="color: black;">能够</span>快速靶向这些细胞进行治疗，而非只能等待它们完成全面耐药，”Nilsson说。</span><span style="color: black;">基于这一<span style="color: black;">发掘</span>，<span style="color: black;">科研</span>人员后来<span style="color: black;">经过</span>靶向CD70的ADC<span style="color: black;">药品</span>、CAR-T疗法以及CAR-NK疗法，证实了这个思路的正确性，<span style="color: black;">她们</span>成功消除了实验室模型中的耐药残留癌细胞。</span><span style="color: black;">虽然这项<span style="color: black;">科研</span>是局限在肺癌的背景下，但CD70的过表达<span style="color: black;">亦</span>存在于许多<span style="color: black;">区别</span>的癌症类型中，如</span><strong style="color: blue;"><span style="color: black;">乳腺癌，胰腺癌，卵巢癌，肾脏癌和黑色素瘤</span></strong><span style="color: black;">。</span><span style="color: black;">“<span style="color: black;">咱们</span>相信，从肺癌EGFR靶向药耐药问题中学到的东西，可能更广泛地适用于其他<span style="color: black;">经过</span>EMT机制耐药的其他癌症，”Heymach说。</span><span style="color: black;"><span style="color: black;"><span style="color: black;">日前</span>，此类基于CD70的治疗策略<span style="color: black;">亦</span>正在针对其他癌症进行临床<span style="color: black;">实验</span>，让<span style="color: black;">咱们</span>拭目以待。</span> </span><span style="color: black;"><span style="color: black;">倘若</span>您<span style="color: black;">期盼</span><span style="color: black;">认识</span><span style="color: black;">更加多</span><span style="color: black;">全世界</span>前沿癌症<span style="color: black;">药品</span>、技术或临床<span style="color: black;">实验</span>信息，或是<span style="color: black;">期盼</span>预约国外权威癌症专家为您<span style="color: black;">供给</span>远程<span style="color: black;">看病</span><span style="color: black;">指点</span>，又或是快速办理国外<span style="color: black;">看病</span>，请</span><strong style="color: blue;"><span style="color: black;">扫描下方二维码</span></strong><span style="color: black;">联系<span style="color: black;">咱们</span>。</span><img src="https://mmbiz.qpic.cn/mmbiz_png/49iaFZeibYsYdNHB8r1ETlMS6R7WvfEsF24oFVsPtuApwrBPWJao8j9jibYSqWUFLG9eYVP7ttoPwlVufVZ7LgFWg/640?wx_fmt=png&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; 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