wrjc1hod 发表于 2024-10-3 07:53:52

Empower虎年小贴士｜网课又双叒叕初始啦


    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">新的一年，恭祝<span style="color: black;">大众</span>虎年新气象！</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">2022年，Empower自然<span style="color: black;">亦</span>要虎虎生威！为减少您工作中的烦忧，沃特世将推出</span><strong style="color: blue;"><span style="color: black;">系列Empower实操利器网课</span></strong><span style="color: black;">，让您的实验分析之路如虎添翼！</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">无论您是刚<span style="color: black;">起始</span><span style="color: black;">运用</span>Empower色谱数据软件(CDS)的新手，还是自20世纪90年代就<span style="color: black;">起始</span><span style="color: black;">运用</span>Waters Millennium软件的资深实验人员都适用！</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">Empower实操网课<span style="color: black;">第1</span>期：ICH杂质卡</span></span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;"><span style="color: black;">第1</span>期<span style="color: black;">咱们</span>将介绍</span><strong style="color: blue;"><span style="color: black;">Empower ICH杂质卡</span></strong><span style="color: black;">。众所周知，杂质<span style="color: black;">科研</span>是<span style="color: black;">药物</span><span style="color: black;">科研</span>的重要方面，它贯穿于<span style="color: black;">全部</span><span style="color: black;">药物</span><span style="color: black;">科研</span>的始终。<span style="color: black;">药物</span>中的杂质<span style="color: black;">是不是</span>能得到<span style="color: black;">恰当</span>、有效的<span style="color: black;">掌控</span>直接关系到<span style="color: black;">药物</span>的质量可控性与安全性，<span style="color: black;">另外</span>，ICH<span style="color: black;">亦</span>对<span style="color: black;">药品</span>检测的杂质报告限度、鉴定限度和质控限度做了<span style="color: black;">知道</span>的规定。</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">本篇<span style="color: black;">文案</span>将着眼于</span><strong style="color: blue;"><span style="color: black;">计算样品中的杂质</span></strong><span style="color: black;">、</span><strong style="color: blue;"><span style="color: black;">设置ICH阈值</span></strong><span style="color: black;">，并<span style="color: black;">运用</span>阈值来标记超过特定水平的杂质。</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">ICH杂质卡<span style="color: black;">运用</span>“五步走”</span></span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">第1步</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">在Review界面，打开“处理<span style="color: black;">办法</span>”，单击“处理<span style="color: black;">办法</span>工具”，<span style="color: black;">而后</span>单击“杂质”选项卡（如下图）。</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">在<span style="color: black;">照片</span>左侧可看到ICH阈值，且在</span><strong style="color: blue;"><span style="color: black;">报告阈值</span></strong>设定了需要报告杂质的限度。<strong style="color: blue;"><span style="color: black;">鉴定阈值</span></strong>设定了杂质需要鉴定的界限，即结构确证。<strong style="color: blue;"><span style="color: black;">质控阈值</span></strong>设定了杂质需要被质控的限度。质控是获取和<span style="color: black;">评定</span>数据的过程，这些数据可在规定的水平上确定单个杂质的生物安全性。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p26-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/5b2db5192be24542a36f6cc95800cd68~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1728090318&amp;x-signature=INMZzlSL1iBo%2Bhbye6yJVqGoklE%3D" style="width: 50%; margin-bottom: 20px;">
      <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图1. “杂质”选项卡界面</p>
    </div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">第2步</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">在定义了这些阈值后可<span style="color: black;">插进</span><span style="color: black;">有些</span>数字，如分别输入 0.025、0.05和0.075（见图2）。</span></span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/587df63db1664c29bb8e03ef2f918d04~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1728090318&amp;x-signature=an1Sxk0YN8why64lLHgrShDaPX4%3D" style="width: 50%; margin-bottom: 20px;">
      <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图2. 定义了阈值后分别输入0.025、0.05 和0.075</p>
    </div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">第3步</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">返回主窗口并</span><strong style="color: blue;"><span style="color: black;">单击“quantitate”</span></strong>。在表格属性中，取消<span style="color: black;">隐匿</span>以下字段：杂质、报告阈值、鉴定阈值和定量阈值（在添加了阈值字段后就不必在主窗口和处理<span style="color: black;">办法</span>之间来回查看阈值设置了多少）。<span style="color: black;">另外</span>，您<span style="color: black;">亦</span><span style="color: black;">能够</span>添加<span style="color: black;">是不是</span>超过阈值字段（图3）。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/905ff70d4ac54302979eeccf9515fb6d~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1728090318&amp;x-signature=2NzjYAPuGZkKZBLpKLe0wgI5BEA%3D" style="width: 50%; margin-bottom: 20px;">
      <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图3. 添加<span style="color: black;">是不是</span>超过阈值字段</p>
    </div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">第4步</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;"><span style="color: black;">首要</span>请<span style="color: black;">重视</span>，杂质字段中带有复选标记的任何峰<span style="color: black;">暗示</span>该杂质已超过报告阈值（图 4）。</span></span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p26-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/d45ac24343b64b898a17879e33871aca~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1728090318&amp;x-signature=TTwR4XcMe6QKIniw98pN1ISSCR0%3D" style="width: 50%; margin-bottom: 20px;">
      <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图4. 杂质字段中带有复选标记的任何峰<span style="color: black;">暗示</span>该杂质已超过报告阈值。</p>
    </div>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">第5步</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">细心的你会<span style="color: black;">发掘</span>图4中名为RRT0.623的杂质峰，它的杂质响应为0.051，超过0.05的鉴定阈值，但系统未有红色标记，这是<span style="color: black;">为何</span>呢？</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">这是<span style="color: black;">因为</span>阈值设置为0.05，而0.051的杂质响应四舍五入为0.05。<span style="color: black;">倘若</span><span style="color: black;">咱们</span>将鉴定阈值修改为0.050，则该峰的杂质响应被标记为超过鉴定阈值（图 5）。</span><strong style="color: blue;"><span style="color: black;">请<span style="color: black;">重视</span></span></strong>，响应超过鉴定阈值的任何杂质都会<span style="color: black;">引起</span>峰名<span style="color: black;">叫作</span>和杂质响应以红色、粗体、斜体字体<span style="color: black;">表示</span>。</span></p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://p3-sign.toutiaoimg.com/tos-cn-i-qvj2lq49k0/562e50fa492b496e834855c1f142303d~noop.image?_iz=58558&amp;from=article.pc_detail&amp;lk3s=953192f4&amp;x-expires=1728090318&amp;x-signature=rYPvKr7haVTwvOM3cn3DiPStilo%3D" style="width: 50%; margin-bottom: 20px;">
      <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">图5. 将鉴定阈值修改为 0.050，该峰的杂质响应被标记为超过鉴定阈值。</p>
    </div>




qzmjef 发表于 2024-11-8 22:35:40

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