警觉，乱吃中草药可能会让肿瘤病人血液的靶向药浓度降低90%，抗癌药治疗没效！
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/uicOLyYe0PeTTKgTamYPzuUG3fS7LRsHLiciaHTmtAPibVsGTzPRf2xFCg2fU36dju0Zyxz76ovnMllEnTF4NBVbQg/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">因为</span>恶性肿瘤是众病之王，<span style="color: black;">因此</span><span style="color: black;">非常多</span>的<span style="color: black;">病人</span>在确诊之后会想尽<span style="color: black;">各样</span>办法去找治疗策略，咱们国家的中草药<span style="color: black;">便是</span>一种，<span style="color: black;">始终</span><span style="color: black;">败兴</span>吃靶向药<span style="color: black;">时期</span>能<span style="color: black;">不可</span>吃中药都是一个问题。<span style="color: black;">大众</span>在就诊的时候<span style="color: black;">能够</span>咨询临床<span style="color: black;">大夫</span>，<span style="color: black;">她们</span><span style="color: black;">通常</span>会回答：“吃靶向药<span style="color: black;">时期</span>不要吃中药。”，当然<span style="color: black;">非常多</span>时候<span style="color: black;">咱们</span>还是会相信中药有某种<span style="color: black;">尤其</span>的奇迹。<span style="color: black;">因此</span>千方百计地去打听<span style="color: black;">各样</span>江湖术士来找“神药丹方”。今天<span style="color: black;">咱们</span>给<span style="color: black;">大众</span>讲述一篇<span style="color: black;">文案</span>，<span style="color: black;">瞧瞧</span>这个<span style="color: black;">病人</span>是在吃靶向药阿西替尼治疗<span style="color: black;">时期</span>，后面经过检测血药浓度降低了90%，这与中草药是有<span style="color: black;">有些</span>什么关系？</p><img src="https://mmbiz.qpic.cn/mmbiz_png/uicOLyYe0PeR1SfQeykrmunlTowiaUJlTVEeqJ5fQPsOOJw1L7n6icAQyp3bXNf7Q79dN6t0xHF9Z5HaXeIYicD74g/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">参考文献刊例图</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">1、</span>肾细胞癌和阿西替尼</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">肾细胞癌占所有癌症的3%，在这些癌症<span style="color: black;">病人</span>中有三分之一会<span style="color: black;">出现</span>转移，肿瘤会转移到肺部、骨、脑、肝、肾上腺和胰腺。尽管手术是局部<span style="color: black;">疾患</span>和特定晚期肾细胞癌最<span style="color: black;">要紧</span>的治疗<span style="color: black;">办法</span>，<span style="color: black;">然则</span><span style="color: black;">近期</span>的<span style="color: black;">有些</span><span style="color: black;">科研</span>数据<span style="color: black;">显示</span>PD-1和抗血管生成靶向药<span style="color: black;">亦</span>起<span style="color: black;">功效</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">截止<span style="color: black;">日前</span>，<span style="color: black;">针对</span>肾细胞癌<span style="color: black;">来讲</span>，<span style="color: black;">无</span>哪一项指标来预判PD-1治疗的效果。在众多的靶向药中，阿西替尼是最为活跃的靶向药，这款靶向药在肾细胞癌的血管生成和肿瘤<span style="color: black;">发展</span>中<span style="color: black;">能够</span>起到很好的<span style="color: black;">控制</span><span style="color: black;">功效</span>，但是这款药的代谢<span style="color: black;">亦</span>存在<span style="color: black;">有些</span><span style="color: black;">重视</span>事项，<span style="color: black;">例如</span>利福平就会影响这款药的代谢。<span style="color: black;">因此</span>就<span style="color: black;">显现</span>了对靶向药的血药浓度进行<span style="color: black;">测绘</span>的<span style="color: black;">状况</span>，<span style="color: black;">亦</span>就有了下面的治疗故事。这<span style="color: black;">病人</span>经历了多次复发，最后才<span style="color: black;">发掘</span>是中草药的<span style="color: black;">原由</span>（自2021年12月就<span style="color: black;">起始</span>用10种草药混合物）。</p><img src="https://mmbiz.qpic.cn/mmbiz_jpg/uicOLyYe0PeR1SfQeykrmunlTowiaUJlTVXqmYkM5Wlia7SqsxiaYwkjyTdEUFnmIQkkkibYiaSgTl3sN7xhu8092VRg/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">2、</span>草药混合物和靶向药的干扰了</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这是一名68岁的白人女子，2021年被确诊为转移性肾细胞癌，这<span style="color: black;">亦</span>是新冠疫情<span style="color: black;">时期</span><span style="color: black;">由于</span>不明<span style="color: black;">原由</span>咳嗽而进行的CT扫描<span style="color: black;">发掘</span>的。这个<span style="color: black;">病人</span>之前吸烟<span style="color: black;">此刻</span><span style="color: black;">已然</span>戒掉了。确诊病情的时候<span style="color: black;">已然</span>转移到肝脏和胰腺，<span style="color: black;">然则</span>她仍然接受了左侧肾切除和脾脏切除。随后她<span style="color: black;">起始</span><span style="color: black;">运用</span>阿西替尼进行辅助治疗，每日两次每次5毫克的阿西替尼，每三周注册一次200毫克的PD-1<span style="color: black;">控制</span>剂帕博利珠单抗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">起始</span>治疗几周后，这个<span style="color: black;">病人</span><span style="color: black;">说到</span>她正在探索肿瘤针灸，<span style="color: black;">况且</span><span style="color: black;">亦</span><span style="color: black;">显现</span>有阿西替尼的不良反应手足<span style="color: black;">综合症</span>。但尽管如此受罪，她在治疗几个月之后就<span style="color: black;">显现</span>了肝转移灶。<span style="color: black;">按照</span><span style="color: black;">病人</span>的意愿对肝部病灶进行了切除。2022年10月<span style="color: black;">时期</span>，核磁<span style="color: black;">发掘</span>肝脏<span style="color: black;">另一</span>一个病灶，这次则是进行了<span style="color: black;">身体</span>放射治疗，最后这种快速且意想不到的动态性肿瘤生长让医生对阿西替尼的血药浓度进行了测试，结果是出乎意料的。<strong style="color: blue;"><span style="color: black;"><span style="color: black;">病人</span>早晨摄入5毫克的阿西替尼6小时，血药浓度仅为2纳克/毫升，这种血药浓度<span style="color: black;">明显</span><span style="color: black;">小于</span>12纳克/毫升（正常用药的血药浓度）</span></strong>。</p><img src="https://mmbiz.qpic.cn/mmbiz_png/uicOLyYe0PeR1SfQeykrmunlTowiaUJlTVoMUeHJFHZulwibLmzIG2nTeMEXRwaNS7Rn7CHTaoicb0vs1QsSXBoTTA/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">阿西替尼的<span style="color: black;">药品</span>浓度严重下降</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">血药浓度低是什么<span style="color: black;">原由</span>呢，<span style="color: black;">科研</span>者做了基因检测<span style="color: black;">发掘</span><span style="color: black;">病人</span><span style="color: black;">无</span>基因层面的问题，对 CYP2C19、CYP2C9、CYP2D6、CYP3A5 和 UGT1A1 进行了基因分型，<span style="color: black;">亦</span><span style="color: black;">无</span><span style="color: black;">发掘</span>遗传方面的问题。<span style="color: black;">然则</span><span style="color: black;">病人</span><span style="color: black;">暗示</span>她<span style="color: black;">每日</span><span style="color: black;">吃下</span>十种草药混合物，这会降低她的胃肠道<span style="color: black;">病痛</span>和治疗的副<span style="color: black;">功效</span>，<span style="color: black;">况且</span>她<span style="color: black;">已然</span>很<span style="color: black;">长期</span>这么用药了。<span style="color: black;">按照</span><span style="color: black;">科研</span>者的<span style="color: black;">意见</span><span style="color: black;">病人</span>停用了这些草药。<strong style="color: blue;"><span style="color: black;">进一步的临床药理学<span style="color: black;">检测</span><span style="color: black;">表示</span>阿西替尼的治疗浓度降低了90%。可能是<span style="color: black;">由于</span>当归和白术等草药<span style="color: black;">导致</span>的。</span></strong></p><img src="https://mmbiz.qpic.cn/mmbiz_png/uicOLyYe0PeR1SfQeykrmunlTowiaUJlTVEDnsvoL1KibPqHDjibkkSjvnbMPsQJ8ib0z6N6ibRGfUiaUxq4RXdSne7icQ/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">病人</span><span style="color: black;">运用</span>的10种草药混合物</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">3、</span>启示</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本文的治疗案例并不是在说<span style="color: black;">大众</span><span style="color: black;">必定</span><span style="color: black;">不可</span>用中医药，而是<span style="color: black;">大众</span>在<span style="color: black;">选取</span>中医药治疗的时候要<span style="color: black;">选取</span>正规的<span style="color: black;">公司</span>，要跟中医师<span style="color: black;">仔细</span>说明您<span style="color: black;">此刻</span><span style="color: black;">运用</span>的靶向药是什么？会不会有什么干扰<span style="color: black;">功效</span>，切忌网上胡乱找到的中医师不<span style="color: black;">必定</span>是有这种能力，要是<span style="color: black;">得到</span>准确答案您可能<span style="color: black;">必须</span>自己准备功课。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">其实<span style="color: black;">倘若</span>不是<span style="color: black;">显现</span>很严重的<span style="color: black;">状况</span>，<span style="color: black;">或</span>实在是迫不得已，癌度不<span style="color: black;">意见</span><span style="color: black;">大众</span>几种治疗<span style="color: black;">办法</span>混用，中草药里的<span style="color: black;">成份</span>是比较<span style="color: black;">繁杂</span>的，<span style="color: black;">常常</span>不<span style="color: black;">晓得</span>什么会干扰到靶向或免疫<span style="color: black;">药品</span>的治疗效果，<strong style="color: blue;"><span style="color: black;"><span style="color: black;">非常多</span>的时候1+1是<span style="color: black;">少于</span>2的，<span style="color: black;">乃至</span>是可能<span style="color: black;">少于</span>1</span></strong>，<span style="color: black;">亦</span>欢迎<span style="color: black;">大众</span>留言<span style="color: black;">通知</span>您的经验和经历。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">关注癌度，为您的抗癌之路保驾护航！</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">参考文献：</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">Friederike Himmelreich, et al, Interference of Herbal Medicine with Axitinib in Metastatic Renal Cell Cancer Treatment: A Case Study, Case Rep Oncol 2023;16:1362–1369.</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌度联合吉因加、华大基因等知名基因检测结构推出基因检测团购计划，<strong style="color: blue;"><span style="color: black;">实体瘤基因检测最低3000元</span></strong>，术后复发监控MRD检测<strong style="color: blue;"><span style="color: black;">最高<span style="color: black;">补助</span>5000元</span></strong>，欢迎<span style="color: black;">大众</span>扫描下面的二维码联系癌度咨询。</p><img src="https://mmbiz.qpic.cn/mmbiz_png/uicOLyYe0PeSppiazIrSIcmYVxOLQ6Zrf3s0keIB78Lc5qaDgFLMbpXL99WRhsvqL6XvRlruoyA3ibQSSShia408LQ/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"> 往期<span style="color: black;">举荐</span> </strong></p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;">8%的恶性肿瘤、32%的乳腺癌存在PIK3CA突变，有什么靶向药？耐药怎么办？</a></p>
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