这种你吃过的常用药，居然能防癌
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">倘若</span>要评选出改变人类历史的10大传奇<span style="color: black;">药品</span>，阿司匹林<span style="color: black;">必定</span>算一个，几乎<span style="color: black;">每一个</span>人都吃过阿司匹林。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">每年<span style="color: black;">全世界</span>阿司匹林的产量多达50000吨，<span style="color: black;">倘若</span>把它们都制成500毫克每片的片剂，其<span style="color: black;">摆列</span>出来的长度足可绕地球25圈！</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">阿司匹林最早<span style="color: black;">做为</span>解热<span style="color: black;">止疼</span>退烧药被广泛应用，民国年间，阿司匹林的<span style="color: black;">宣传</span>就<span style="color: black;">非常多</span>了，专治头痛、牙痛、伤风、寒热等症。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q0.itc.cn/q_70/images03/20240419/2f6405c9f0ca4e13a45cdb410cc78c51.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：网络）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1971年，<span style="color: black;">专家</span>范恩<span style="color: black;">（John Vane）</span><span style="color: black;">发掘</span>阿司匹林能<strong style="color: blue;">减轻血栓<span style="color: black;">危害</span></strong>，就此阿司匹林在心血管方面的<span style="color: black;">功效</span>首次被<span style="color: black;">发掘</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q8.itc.cn/q_70/images03/20240419/25103e350c6f43cc8746ce7c23cd3c9c.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">专家</span>John Vame，后来<span style="color: black;">得到</span>诺贝尔奖。）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">如今阿司匹林<span style="color: black;">已然</span>是心脑血管<span style="color: black;">疾患</span>高危人群中的一级和二级预防的<span style="color: black;">举荐</span>用药，还<span style="color: black;">能够</span>用来治疗<span style="color: black;">有些</span>特殊的<span style="color: black;">疾患</span></strong>：如解救川崎病患儿免受炎症反应，用于糖尿病和阿尔茨海默症的治疗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在诞生120<span style="color: black;">数年</span>后，阿司匹林再一次<span style="color: black;">作为</span><span style="color: black;">研究</span><span style="color: black;">行业</span>的新星。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这一次，是<span style="color: black;">由于</span>抗癌：<strong style="color: blue;">“抗癌<span style="color: black;">爱宠</span>”——阿司匹林。</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q1.itc.cn/q_70/images03/20240419/c5f8b09326a643088c667fc8bdf1dce5.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：giphy）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在医疗<span style="color: black;">行业</span>，当一种<span style="color: black;">药品</span>被<span style="color: black;">加入</span>指南<span style="color: black;">举荐</span>，<span style="color: black;">寓意</span>着这种<span style="color: black;">药品</span>的疗效有扎实的证据<span style="color: black;">基本</span>，并得到了医学界的公认。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2016年，美国预防医学工作组<span style="color: black;">(USPSTF,U.S. ）</span>，<strong style="color: blue;">正式将阿司匹林<span style="color: black;">准许</span>为结直肠癌一级预防<span style="color: black;">药品</span><span style="color: black;"></span></strong>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q3.itc.cn/q_70/images03/20240419/db352c4ab73541a8991b19803b234cc2.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：giphy）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">其实早在2009年，The Lancet Oncology<span style="color: black;">（《柳叶刀肿瘤》）</span>就总结了阿司匹林预防结肠癌和其他癌症的成果，<span style="color: black;">然则</span>因<span style="color: black;">科研</span>数据不足，当时科学界认为阿司匹林<span style="color: black;">做为</span>抗癌<span style="color: black;">药品</span>，还存在<span style="color: black;">非常多</span>争议<span style="color: black;"></span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">某种<span style="color: black;">道理</span>上，这<span style="color: black;">亦</span><span style="color: black;">作为</span>阿司匹林开启抗癌疗效之路的起点。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q7.itc.cn/q_70/images03/20240419/89696d1a96754087be5f6a6b27279225.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：soogif）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">幸运的是，<span style="color: black;">火速</span>就迎来曙光。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2年后，The Lancet<span style="color: black;">（《柳叶刀》）</span>针对阿司匹林<span style="color: black;">发布</span>了一篇学术论文，<strong style="color: blue;">提出<span style="color: black;">长时间</span><span style="color: black;">吃下</span>阿司匹林能够降低遗传性结肠癌的患癌概率</strong><span style="color: black;"></span>；随后，JAMA<span style="color: black;">子刊</span><span style="color: black;">（《美国医学会杂志》<span style="color: black;">子刊</span>）</span><span style="color: black;">亦</span>证明阿司匹林<span style="color: black;">针对</span>结肠癌<span style="color: black;">病人</span>有治疗作用，<span style="color: black;">吃下</span>阿司匹林的<span style="color: black;">病人</span>，<strong style="color: blue;">死亡率<span style="color: black;">显著</span><span style="color: black;">小于</span>未<span style="color: black;">吃下</span>组</strong><span style="color: black;"></span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">一篇又一篇临床<span style="color: black;">科研</span>数据，都在夯实阿司匹林治疗结直肠癌的证据<span style="color: black;">基本</span>！</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">直到2016年，阿司匹林<span style="color: black;">作为</span>结直肠癌一级预防指南<span style="color: black;">举荐</span><span style="color: black;">药品</span>。阿司匹林就此<span style="color: black;">最终</span>“<span style="color: black;">数年</span>的媳妇熬成婆”，正式进军癌症治疗<span style="color: black;">行业</span>！</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q3.itc.cn/q_70/images03/20240419/c172548d4a3744328db3c45f0ffaaf02.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：giphy）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1年后，<span style="color: black;">专家</span>又<span style="color: black;">科研</span><span style="color: black;">发掘</span>，结直肠癌<span style="color: black;">病人</span>确诊后<span style="color: black;">吃下</span>阿司匹林的临床效果取决于肿瘤亚型，幸运的是，<strong style="color: blue;">阿司匹林效果最好的亚型恰好是结直肠癌最<span style="color: black;">平常</span>的亚型，死亡率足足降低了40%</strong><span style="color: black;"></span>！</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">许多<span style="color: black;">科研</span>证明了阿司匹林预防癌症的<span style="color: black;">功效</span>，以结直肠癌为例，今年<span style="color: black;">发布</span>在《Ann Oncol》的一篇<span style="color: black;">文案</span><span style="color: black;">显示</span><span style="color: black;"></span>，针对结直肠癌，阿司匹林<span style="color: black;">运用</span>剂量越高，<span style="color: black;">危害</span>降低越大：<span style="color: black;">每日</span>100mg，发病<span style="color: black;">危害</span>降低13%；<span style="color: black;">每日</span>325mg，发病<span style="color: black;">危害</span>降低35%；<span style="color: black;">每日</span>500mg，发病<span style="color: black;">危害</span>降低50%。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">没错，<span style="color: black;">每日</span>吃阿司匹林500mg，结直肠癌发病<span style="color: black;">危害</span>降低50%！</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q8.itc.cn/q_70/images03/20240419/b4a628285f934f81a0878324180bfa91.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：soogif）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">除了剂量外，<span style="color: black;">科研</span><span style="color: black;">表示</span>，<span style="color: black;">吃下</span>阿司匹林时间越久，结直肠癌发病<span style="color: black;">危害</span>降低越多</strong><span style="color: black;"></span>。<strong style="color: blue;">常规<span style="color: black;">运用</span>阿司匹林1年，结直肠癌发病<span style="color: black;">危害</span>会降低4%；<span style="color: black;">运用</span>5年，发病<span style="color: black;">危害</span>降低19%；<span style="color: black;">运用</span>10年，发病<span style="color: black;">危害</span>降低29%！</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">阿司匹林的抗癌<span style="color: black;">功效</span>远不止结直肠癌：</p>梅奥诊所的<span style="color: black;">科研</span>人员<span style="color: black;">发掘</span><span style="color: black;">吃下</span>阿司匹林的人<span style="color: black;">出现</span>胆管癌的<span style="color: black;">危害</span><span style="color: black;">明显</span>降低。
美国癌症<span style="color: black;">科研</span>协会（AACR）的学会上，来自哈佛医学院的博士提出<span style="color: black;">吃下</span>阿司匹林的乳腺癌<span style="color: black;">病人</span>和前列腺癌<span style="color: black;">病人</span>的死亡率降低了11%和23%。
<span style="color: black;">每日</span><span style="color: black;">吃下</span>阿司匹林，患食管癌和胃癌的<span style="color: black;">危害</span>能够降低30％，死于这些癌症的<span style="color: black;">危害</span>降低35％-50％。<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q9.itc.cn/q_70/images03/20240419/dfd5ef7fb59f46688dbd29f13373640d.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：giphy）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">说到<span style="color: black;">这儿</span>，有人要问了：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">阿司匹林不是退烧、<span style="color: black;">止疼</span>、抗炎、心血管药吗？<span style="color: black;">为何</span>会“不务正业”，有抗癌的疗效呢？</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">阿司匹林的抗癌<span style="color: black;">功效</span>机制，<span style="color: black;">重点</span>从两方面<span style="color: black;">来讲</span>：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q5.itc.cn/q_70/images03/20240419/e79accd89d46419b868ede45b6e024ff.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：giphy）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">首要</span>是抗炎<span style="color: black;">功效</span></strong>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">许多人不<span style="color: black;">晓得</span>的是：慢性炎症恰恰是肿瘤发展的巨大<span style="color: black;">走狗</span>！</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">医学上的炎症，指的是血管系统抵抗<span style="color: black;">损害</span>的过程，<span style="color: black;">全部</span>过程简单<span style="color: black;">来讲</span><span style="color: black;">便是</span><span style="color: black;">损害</span>、抗<span style="color: black;">损害</span>、修复。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">炎症发展过程中会促进血管生长，<span style="color: black;">从而</span>为肿瘤细胞带去氧气和营养，<span style="color: black;">同期</span>产生自由基进一步损害DNA<span style="color: black;"></span></strong>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q2.itc.cn/q_70/images03/20240419/9d22414f39d14b40aff611f1e5bbe0e2.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：giphy）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">阿司匹林正是<span style="color: black;">经过</span><span style="color: black;">掌控</span>炎症发展来抗癌的！</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">其次是抗血栓<span style="color: black;">功效</span>。</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌细胞想要从<span style="color: black;">本来</span>的位置扩散到全身，<span style="color: black;">必要</span>想办法冲破血管壁，进入血液循环系统，在到达目的地后，再突破血管壁，侵犯相应的器官组织，从而完成转移与扩散<span style="color: black;"></span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q3.itc.cn/q_70/images03/20240419/4c8f1e553a2941b68ff5904101298fcb.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：giphy）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这个过程中，<span style="color: black;">倘若</span>许许多多个癌细胞抱团起来，转移成功率更高，于是聪明的癌细胞“挟持”了<span style="color: black;">拥有</span>黏附作用的血小板，把自己和同类打包在<span style="color: black;">一块</span>，悄咪咪地在身<span style="color: black;">身体</span>进行转移<span style="color: black;"></span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q8.itc.cn/q_70/images03/20240419/95fd1164fb5440d8982e7b272aca8908.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：soogif）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">阿司匹林恰恰是<span style="color: black;">经过</span><span style="color: black;">控制</span>血小板的活化，降低黏附功能，让癌细胞<span style="color: black;">不可</span>“挟持”血小板抱团，从而<span style="color: black;">控制</span>癌细胞的转移<span style="color: black;"></span></strong>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">读到<span style="color: black;">这儿</span>有人说了——</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">阿司匹林这么好，是不是想<span style="color: black;">马上</span>转发给爸爸妈妈爷爷奶奶七大姑八大姨？</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q7.itc.cn/q_70/images03/20240419/a25198257bed4287bdea115111158621.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：soogif）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">能平常吃<span style="color: black;">阿司匹林</span>来预防癌症吗？</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">阿司匹林确实能预防癌症，但<span style="color: black;">仅有</span>相应的适应症的人适合用。</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2016年，美国预防服务工作组<span style="color: black;">举荐</span>阿司匹林<span style="color: black;">做为</span>结直肠癌一级预防<span style="color: black;">药品</span>指南，<span style="color: black;">知道</span>写道：<strong style="color: blue;">10年心血管<span style="color: black;">危害</span>≥10%且<span style="color: black;">没</span><span style="color: black;">流血</span><span style="color: black;">危害</span><span style="color: black;">增多</span>的50~69岁人群，应<span style="color: black;">思虑</span><span style="color: black;">吃下</span>低剂量阿司匹林来预防心血管病和结直肠癌<span style="color: black;"></span></strong>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">结直肠癌之外，其他<span style="color: black;">行业</span>的抗癌<span style="color: black;">功效</span>还在<span style="color: black;">科研</span>，<span style="color: black;">日前</span>还没得到科学界公认，<span style="color: black;">因此</span>更不<span style="color: black;">意见</span><span style="color: black;">自动</span>服药来预防。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">是药三分毒。<strong style="color: blue;">所有的药都有副<span style="color: black;">功效</span>，阿司匹林<span style="color: black;">亦</span>不例外。<span style="color: black;">仅有</span>适应症人群<span style="color: black;">吃下</span>，对身体的好处才是大于副<span style="color: black;">功效</span>的</strong>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">阿司匹林的副<span style="color: black;">功效</span>有胃肠道<span style="color: black;">流血</span>、过敏以及<span style="color: black;">头昏</span>等神经系统症状。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">其中最值得关注的副<span style="color: black;">功效</span>是消化道<span style="color: black;">流血</span>。</strong><span style="color: black;">由于</span>阿司匹林有抵抗血小板凝聚的<span style="color: black;">功效</span>，<span style="color: black;">因此</span><span style="color: black;">针对</span>血液系统有<span style="color: black;">阻碍</span><span style="color: black;">或</span>过量<span style="color: black;">吃下</span>的人群<span style="color: black;">来讲</span>，就会有自发<span style="color: black;">流血</span>的<span style="color: black;">危害</span>，<span style="color: black;">例如</span>在刷牙的时候会有牙龈<span style="color: black;">流血</span>，皮肤表皮<span style="color: black;">流血</span>瘀斑等现象，最危险的<span style="color: black;">便是</span>消化道大<span style="color: black;">流血</span>，严重者可危及生命。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q0.itc.cn/q_70/images03/20240419/dee68d5a1a964f46ab0af64aab8250ac.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：soogif）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">关于这点，<span style="color: black;">倘若</span>有家人正在<span style="color: black;">吃下</span>阿司匹林，你其实<span style="color: black;">亦</span>不必过于担心，<span style="color: black;">科研</span><span style="color: black;">表示</span>，<strong style="color: blue;"><span style="color: black;">吃下</span>阿司匹林的人和不<span style="color: black;">吃下</span>阿司匹林的人，10年累计消化道<span style="color: black;">流血</span>率分别为7.8%和6.9%，并<span style="color: black;">无</span><span style="color: black;">明显</span>差异</strong><span style="color: black;"></span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">但说到底，还是那句话，阿司匹林是药，不是营养品，没病的人别乱吃！</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">必定</span><span style="color: black;">必定</span>，要与<span style="color: black;">大夫</span>讨论<span style="color: black;">运用</span>阿司匹林的潜在<span style="color: black;">危害</span>及其可能的获益<span style="color: black;">状况</span>，再决定要不要<span style="color: black;">吃下</span>阿司匹林，尤其是有<span style="color: black;">药品</span>过敏、血小板低、消化道溃疡等其他<span style="color: black;">疾患</span>的人，更应<span style="color: black;">谨慎</span>咨询<span style="color: black;">大夫</span>意见。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">阿司匹林经过了传奇般的演进，履历还在<span style="color: black;">持续</span>更新，可能<span style="color: black;">将来</span>某一天，阿司匹林还会<span style="color: black;">留意</span>想不到的<span style="color: black;">地区</span>发挥<span style="color: black;">功效</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">其实，又何止阿司匹林呢？</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">现代<span style="color: black;">药品</span>从发明到上市，<span style="color: black;">常常</span>要十<span style="color: black;">数年</span>时间，花费十多亿美金，但上市并不是终点，只是一个里程碑。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">许许多多的老药在<span style="color: black;">一直</span>制造着新惊喜，<span style="color: black;">此刻</span>的绝症可能在<span style="color: black;">将来</span>就能被<span style="color: black;">咱们</span>已知的某个药物治愈，科学总是在曲折中<span style="color: black;">持续</span>进步，螺旋<span style="color: black;">提升</span>。</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q8.itc.cn/q_70/images03/20240419/709d7035f8a246bcb79e3e5793836c25.gif" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">（<span style="color: black;">源自</span>：giphy）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">审稿专家：</strong><strong style="color: blue;">宋永朝</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">河北医科大学<span style="color: black;">第1</span>医院主管药师、执业药师</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">参考文献</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Bibbins-Domingo, K. and U.S.P.S.T. Force, Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement . Ann Intern Med, 2016. 164(12): 836-45.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Cuzick, J., F. Otto, J.A. Baron, et al., Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement . Lancet Oncol, 2009. 10(5): 501-7.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Antonoff, M.B. and J. DCunha, Killing two birds with one salicylate: aspirins dual roles in preventative health . Semin Thorac Cardiovasc Surg, 2011. 23(2): 96-8.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Reimers, M.S., E. Bastiaannet, R.E. Langley, et al., Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer . JAMA Intern Med, 2014. 174(5): 732-9.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Hua, X., A.I. Phipps, A.N. Burnett-Hartman, et al., Timing of Aspirin and Other Nonsteroidal Anti-Inflammatory Drug Use Among Patients With Colorectal Cancer in Relation to Tumor Markers and Survival . J Clin Oncol, 2017. 35(24): 2806-2813.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Bosetti, C., C. Santucci, S. Gallus, et al., Aspirin and the risk of colorectal and other digestive tract cancers: an updated meta-analysis through 2019 . Ann Oncol, 2020. 31(5): 558-568.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Choi, J., H.M. Ghoz, T. Peeraphatdit, et al., Aspirin use and the risk of cholangiocarcinoma . Hepatology, 2016. 64(3): 785-96.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Yin Cao, Meir Stampfer, Walter Willett, Donna Spiegelman, et al. Long-term aspirin use and total and cancer-specific mortality . In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3012. doi:10.1158/1538-7445.AM2017-3012</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Cuzick, J., M.A. Thorat, C. Bosetti, et al., Estimates of benefits and harms of prophylactic use of aspirin in the general population . Ann Oncol, 2015. 26(1): 47-57.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Murata, M., Inflammation and cancer . Environ Health Prev Med, 2018. 23(1): 50.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Lucotti, S., C. Cerutti, M. Soyer, et al., Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2 . J Clin Invest, 2019. 129(5): 1845-1862.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Bosetti, C., C. Santucci, S. Gallus, et al., Aspirin and the risk of colorectal and other digestive tract cancers: an updated meta-analysis through 2019 . Ann Oncol, 2020. 31(5): 558-568.</p>
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