打一针就能预防癌症？
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">谈癌色变，癌症似乎<span style="color: black;">作为</span>极度痛苦、衰弱和死亡的代名词,对任何人都是一个从精神到肉体的<span style="color: black;">剧烈</span>刺激!在大<span style="color: black;">都数</span>人心中，癌症<span style="color: black;">常常</span>与“绝症”是同义词，癌症的可怕源自人们对不治之症的恐惧。癌症难以<span style="color: black;">初期</span><span style="color: black;">发掘</span>，<span style="color: black;">非常多</span>癌症<span style="color: black;">发掘</span>时已<span style="color: black;">处在</span>晚期；且容易转移难以治疗，现有的治疗手段<span style="color: black;">没</span>论是手术、放疗、化疗还是<span style="color: black;">药品</span>治疗都有各自的局限，难以彻底治愈癌。</p>
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<h1 style="color: black; text-align: left; margin-bottom: 10px;"><strong style="color: blue;"><span style="color: black;">以国人平均寿命75岁来估算，<span style="color: black;">每一个</span>人<span style="color: black;">一辈子</span>中患癌的可能性在1/3以上!癌症其实是<span style="color: black;">平常</span>病，它的影响之大，受害者之多，治愈之难，足以使它排在人类<span style="color: black;">疾患</span>榜的前列。</span></strong></h1>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/sz_mmbiz_jpg/FLOYjKAYNUE3dM5GrJn25w24uibFOXhOQ0H5dJ6rcpvqhgjDevFh9gRoDx4kYD3OnWevZu4qKEcKUDyxALPt1lQ/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></span></strong></p><img src="https://mmbiz.qpic.cn/mmbiz_gif/bL2iaicTYdZn4PfZhVn8nPMBOW1v8NKWwoYRQlVTPMbnlc8RcjoHOpGsIpeEPK4LPjMu6ScdjsL9wfXliaHBHIQ9g/640?wx_fmt=gif&tp=webp&wxfrom=5&wx_lazy=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">CAR-T疗法——给生命再生的机会</strong></p><img src="https://mmbiz.qpic.cn/mmbiz_gif/bL2iaicTYdZn4UQsuSPibycgVNox22LQBnDAUuT35qGmgNgPv7mRfrpHyjiafXxk9Ehgib1lB41DbUQBTHRJ0VIY6Fw/640?wx_fmt=gif&tp=webp&wxfrom=5&wx_lazy=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">2021年9月份一个<span style="color: black;">资讯</span>刷爆<span style="color: black;">伴侣</span>圈，上海一位60多岁的陈阿姨，确诊了淋巴癌且<span style="color: black;">没</span>法<span style="color: black;">经过</span>传统<span style="color: black;">办法</span>治疗了，<span style="color: black;">经过</span>120万一针的CAR-T细胞免疫疗法治疗，结果两个月之后痊愈出院了，且全身的癌细胞都<span style="color: black;">已然</span><span style="color: black;">无</span>了。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">此时，CAR-T疗法正式走进了老<span style="color: black;">大众</span>的视野里，那什么CAR-T治疗是什么呢？</span>CAR-T疗法即嵌合抗原受体T细胞免疫疗法，是一种治疗肿瘤的新型<span style="color: black;">精细</span>细胞免疫疗法。在实验室，技术人员<span style="color: black;">经过</span>基因工程技术，将T细胞激活，装上定位导航<span style="color: black;">安装</span>CAR（肿瘤嵌合抗原受体），将T细胞这个普通“战士”改<span style="color: black;">导致</span>“超级战士”，即CAR-T细胞，他利用“定位导航<span style="color: black;">安装</span>”CAR，专门识别<span style="color: black;">身体</span>肿瘤细胞，并<span style="color: black;">经过</span>免疫<span style="color: black;">功效</span>释放<span style="color: black;">海量</span>的多种效应因子，<span style="color: black;">有效</span>地杀灭肿瘤细胞，达到治疗恶性肿瘤的目的。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/sz_mmbiz_png/FLOYjKAYNUE3dM5GrJn25w24uibFOXhOQ12KmrtHV3tgE5zjJicydXWfOvcY1kjCoyRae7Kbnib2droiawia0MJVmgw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">1</span><span style="color: black;">2</span><span style="color: black;">0</span><span style="color: black;">万</span><span style="color: black;">一</span><span style="color: black;">针</span><span style="color: black;">打</span><span style="color: black;">了</span><span style="color: black;">要</span><span style="color: black;">钱</span><span style="color: black;">不</span><span style="color: black;">打</span><span style="color: black;">要</span><span style="color: black;">命</span><span style="color: black;">都</span><span style="color: black;">说</span><span style="color: black;">生</span><span style="color: black;">命</span><span style="color: black;">是</span><span style="color: black;">平</span><span style="color: black;">等</span><span style="color: black;">的</span><span style="color: black;">但</span><span style="color: black;">有</span><span style="color: black;">的</span><span style="color: black;">时</span><span style="color: black;">候</span><span style="color: black;">金</span><span style="color: black;">钱</span><span style="color: black;">的</span><span style="color: black;">厚</span><span style="color: black;">度</span><span style="color: black;">直</span><span style="color: black;">接</span><span style="color: black;">决</span><span style="color: black;">定</span><span style="color: black;">生</span><span style="color: black;">命</span><span style="color: black;">的</span><span style="color: black;">长</span><span style="color: black;">度。</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">尽管CAR-T疗法在急性白血病和非霍奇金淋巴瘤的治疗上<span style="color: black;">拥有</span><span style="color: black;">明显</span>的疗效，为部分复发或难治性血液肿瘤<span style="color: black;">病人</span>带来了新的<span style="color: black;">期盼</span>，<span style="color: black;">然则</span>一次性拿出120万让大部分的人很难办到</span><span style="color: black;">。</span>CAR-T治疗虽然在院内治疗，但大额缴费在院外，不属于百万医疗<span style="color: black;">保证</span>范围。百万医疗险是<span style="color: black;">能够</span>报销自费药，<span style="color: black;">然则</span>只限于“院内药” <span style="color: black;">才可</span><span style="color: black;">得到</span>报销。除非百万医疗有全行业性质的大更新，<span style="color: black;">否则</span>是<span style="color: black;">不可</span>报销CAR-T治疗<span style="color: black;">花费</span>的。<span style="color: black;">最少</span>在<span style="color: black;">将来</span>一段时间很难实现报销CAR-T的政策。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/sz_mmbiz_png/FLOYjKAYNUE3dM5GrJn25w24uibFOXhOQQj9jGuzclmZzEXopoRhyPtQdjOrQgh0GsUtrAbJicicZYGtg9bEI4HFg/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">“打一针就能预防癌症，这是我的终极<span style="color: black;">目的</span>”</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">有<span style="color: black;">这般</span>一个团队，二十<span style="color: black;">数年</span>来<span style="color: black;">始终</span><span style="color: black;">保持</span><span style="color: black;">科研</span>热休克蛋白gp96免疫学功能和生物学功能，聚焦乙肝病毒与肝癌等肿瘤免疫、<span style="color: black;">自己</span>免疫<span style="color: black;">疾患</span>，<span style="color: black;">创立</span>了以热休克蛋白gp96<span style="color: black;">做为</span>T细胞佐剂<span style="color: black;">开发</span>平台。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">团队经<span style="color: black;">太多</span>年<span style="color: black;">科研</span><span style="color: black;">发掘</span>，从健康人胎盘提取的热休克蛋白gp96，天然结合胎盘中52种癌胚抗原，<span style="color: black;">经过</span>注射后可活化人体特异性T细胞，杀伤<span style="color: black;">处在</span>快速生长的肿瘤细胞，<span style="color: black;">加强</span>机体抗肿瘤的免疫力。临床<span style="color: black;">实验</span><span style="color: black;">已然</span>证明，<span style="color: black;">源自</span>于肿瘤<span style="color: black;">病人</span>肿瘤组织的gp96<span style="color: black;">拥有</span>良好的抗肿瘤免疫活性。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在“2021港科大百万奖金国际创业大赛”中，热休克蛋白GP96凭借在治疗癌症和<span style="color: black;">自己</span>免疫性<span style="color: black;">疾患</span>方面的功效，因其<span style="color: black;">拥有</span>靶点新颖、安全有效、<span style="color: black;">无</span><span style="color: black;">药品</span>依赖性和市场广阔等特点，在100多个项目脱颖而出，斩获“最具投资价值奖”。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">细分GP96<span style="color: black;">行业</span>，<span style="color: black;">日前</span><span style="color: black;">全世界</span>共有三家实验室在做，两家在美国，<span style="color: black;">另一</span>一家正是国内孟颂东教授的实验室。孟颂东在美国西南医学中心肿瘤免疫中心学成归来后，20<span style="color: black;">数年</span>来<span style="color: black;">始终</span>从事热休克蛋白GP96的<span style="color: black;">基本</span>和应用<span style="color: black;">科研</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">孟颂东教授说：</span><strong style="color: blue;"><span style="color: black;">“打一针就能预防癌症，这是我的终极<span style="color: black;">目的</span>”</span></strong><span style="color: black;">。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/sz_mmbiz_png/FLOYjKAYNUE3dM5GrJn25w24uibFOXhOQFfbghaKbmTSUcr9lq5ugucLfk8icxwvzoaraVqb5tGtO98PQcmzfPhA/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">简单<span style="color: black;">来讲</span></span><span style="color: black;">GP96是一种蛋白质，属于热休克蛋白家族，而这个蛋白家族<span style="color: black;">拥有</span>天然结合<span style="color: black;">各样</span>抗原的特性。<span style="color: black;">因此呢</span>胎盘中提取的GP96，天然结合胎盘中的52种癌胚抗原，其进入人<span style="color: black;">身体</span>后将此抗原信息递呈给免疫系统，就相当于给免疫系统<span style="color: black;">供给</span>了癌细胞的照片，使其更易识别<span style="color: black;">身体</span>的癌细胞，并将其消灭。</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">GP96与CAR-T有<span style="color: black;">那些</span>区别？</span></strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">功效</span>机理不同</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">CAR-T<span style="color: black;">制品</span>是抽取<span style="color: black;">病人</span>血液后，在体外，利用基因工程技术对T细胞进行改造，让它<span style="color: black;">作为</span>更好地识别并且攻击肿瘤的CAR-T免疫细胞，<span style="color: black;">而后</span>再注入<span style="color: black;">身体</span>，它<span style="color: black;">能够</span>在癌细胞的干扰下继续识别并消灭癌细胞。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">热休克蛋白GP96与CAR-T<span style="color: black;">制品</span>其最<span style="color: black;">明显</span>的区别是：<span style="color: black;">全部</span><span style="color: black;">功效</span>过程是在<span style="color: black;">身体</span>进行的。<span style="color: black;">病人</span><span style="color: black;">没</span>需抽血，只<span style="color: black;">必须</span>将GP96<span style="color: black;">经过</span>腋下淋巴结注入<span style="color: black;">身体</span>，<span style="color: black;">就可</span>激活免疫细胞，实现对癌细胞的消灭和预防。该蛋白制剂不止对癌症人群有效，健康人群<span style="color: black;">一样</span><span style="color: black;">能够</span>获益。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">适用范围不同</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">日前</span>CAR-T疗法应用最多的还是血液肿瘤<span style="color: black;">行业</span>，但血液肿瘤<span style="color: black;">病人</span>在所有癌症<span style="color: black;">病人</span>中只占到10%<span style="color: black;">上下</span>的比例。更高比例的实体肿瘤，<span style="color: black;">因为</span>有脱靶效应、免疫细胞<span style="color: black;">很难</span>进入实体瘤内部等<span style="color: black;">原因</span>，该应用尚<span style="color: black;">处在</span>临床前期<span style="color: black;">实验</span><span style="color: black;">周期</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">GP96<span style="color: black;">因为</span>其携带多种癌胚抗原信息，适合胃癌、肝癌、肺癌、结直肠癌、肾癌、乳腺癌等十几种实体肿瘤的术后治疗。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">副<span style="color: black;">功效</span>不同</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">CAR-T疗法的<span style="color: black;">重点</span>副<span style="color: black;">功效</span>是细胞因子释放<span style="color: black;">综合症</span>，严重者可<span style="color: black;">引起</span>多器官功能衰竭<span style="color: black;">或</span>急性<span style="color: black;">呼气</span>窘迫<span style="color: black;">综合症</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">GP96因其独特的天然性，<span style="color: black;">无</span><span style="color: black;">显著</span>毒副反应，该<span style="color: black;">药品</span>潜在的毒副<span style="color: black;">功效</span><span style="color: black;">包含</span>轻微疲劳以及<span style="color: black;">平常</span>蛋白疫苗的轻微副反应等。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">价格不同</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">CAR-T<span style="color: black;">制品</span><span style="color: black;">因为</span><span style="color: black;">必须</span>支付<span style="color: black;">昂贵</span>的“个性化治疗”<span style="color: black;">花费</span>，仅一针就<span style="color: black;">必须</span>120万元。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">GP96蛋白制剂，胎盘中提取，<span style="color: black;">没</span>需额外<span style="color: black;">包袱</span>个性化改造的<span style="color: black;">花费</span>，价格不及CAR-T<span style="color: black;">制品</span>的<span style="color: black;">非常</span>之一。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">免疫疗法的<span style="color: black;">显现</span>是近年来临床上的巨大突破，两者的不同<span style="color: black;">亦</span>给癌症<span style="color: black;">病人</span><span style="color: black;">加强</span>了对抗病魔的决心和<span style="color: black;">保持</span>活下去的<span style="color: black;">期盼</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">随着患癌率越来越高，人们对各类癌症早已不陌生。不管从家庭层面还是国家层面来看，癌症都是一个巨大的经济<span style="color: black;">包袱</span>，且随着时间的推移，癌症的<span style="color: black;">包袱</span>越来越大。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">在美国的癌症统计报告中<span style="color: black;">表示</span>，预计到2022年，<strong style="color: blue;">美国将有约</strong></span><span style="color: black;"><strong style="color: blue;">237万例新发癌症</strong></span><span style="color: black;"><strong style="color: blue;">和</strong></span><span style="color: black;"><strong style="color: blue;">64万例癌症</strong></span><span style="color: black;"><strong style="color: blue;">死亡</strong>；而在陈教授的论文中<span style="color: black;">说到</span>，<strong style="color: blue;">我国的数据是</strong><strong style="color: blue;">约</strong></span><span style="color: black;"><strong style="color: blue;">482万例新发癌症</strong></span><span style="color: black;"><strong style="color: blue;">和</strong></span><span style="color: black;"><strong style="color: blue;">321万例癌症</strong></span><span style="color: black;"><strong style="color: blue;">死亡</strong>。</span><span style="color: black;"><strong style="color: blue;"><span style="color: black;">亦</span><span style="color: black;">便是</span>说，</strong></span><strong style="color: blue;">我国癌症的新发病例数约为美国的2倍，死亡病例约为5倍。</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">癌症致病<span style="color: black;">原因</span><span style="color: black;">繁杂</span>，防治难度大，给家庭、个人和社会经济发展带来了巨大的挑战。国内外的经验<span style="color: black;">显示</span>，采取<span style="color: black;">初期</span>预防、<span style="color: black;">初期</span>筛查、<span style="color: black;">初期</span>治疗等防治<span style="color: black;">办法</span>，<span style="color: black;">针对</span>降低癌症的发病和死亡<span style="color: black;">拥有</span><span style="color: black;">明显</span>的效果。</span></strong></p><img src="https://mmbiz.qpic.cn/mmbiz_gif/Ljib4So7yuWgv7wK9VmNicSzHAcfCNbwLpfugYPhpT45AQlcPfmInGGshAOeFzOhU0nbzJtzCWC4PYaWfmE22eeQ/640?wx_fmt=gif&tp=webp&wxfrom=5&wx_lazy=1" style="width: 50%; margin-bottom: 20px;"><img src="https://mmbiz.qpic.cn/mmbiz_gif/bL2iaicTYdZn4UQsuSPibycgVNox22LQBnDD0NdumaMoicrNPKGwwtFSl9sNEHkmkYibOymTOVNSWLjzicQXiaXITbQzA/640?wx_fmt=gif&tp=webp&wxfrom=5&wx_lazy=1" style="width: 50%; margin-bottom: 20px;"><img src="https://mmbiz.qpic.cn/mmbiz_gif/Ljib4So7yuWgv7wK9VmNicSzHAcfCNbwLpfugYPhpT45AQlcPfmInGGshAOeFzOhU0nbzJtzCWC4PYaWfmE22eeQ/640?wx_fmt=gif&tp=webp&wxfrom=5&wx_lazy=1" style="width: 50%; margin-bottom: 20px;">
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