专家有望研发出一种更有效的癌症疫苗策略
<h1 style="color: black; text-align: left; margin-bottom: 10px;"><span style="color: black;">源自</span>:生物谷</h1>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">近期</span>,来自杜克大学等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span>,利用树突细胞前体细胞<span style="color: black;">做为</span>一种<span style="color: black;">有效</span>有效的<span style="color: black;">办法</span>成功刺激机体免疫系统来抵御癌症,<span style="color: black;">关联</span><span style="color: black;">科研</span>结果刊登于国际杂志Journal of Clinical Investigation上;<span style="color: black;">关联</span><span style="color: black;">科研</span>结果或能<span style="color: black;">供给</span>树突细胞癌症疫苗的替代<span style="color: black;">制品</span>,其能<span style="color: black;">做为</span>一种新<span style="color: black;">办法</span>来促进T细胞有效识别并攻击癌细胞,但在<span style="color: black;">加强</span>病人存活率上成效却非常有限。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q5.itc.cn/images01/20240524/4b455b2a63dd41a9a322656a170945e3.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这种新<span style="color: black;">办法</span>能够利用单核细胞来发挥<span style="color: black;">功效</span>,单核细胞是一种白细胞,<span style="color: black;">同期</span><span style="color: black;">亦</span>是树突细胞的先驱,当单核细胞被装载上抗原并被注射到小鼠<span style="color: black;">身体</span>时,其就会间接诱导机体<span style="color: black;">显现</span>攻击肿瘤组织的T细胞反应。<span style="color: black;">科研</span>者Michael D. Gunn<span style="color: black;">暗示</span>,这是一种全新的<span style="color: black;">办法</span>,相比树突细胞疫苗而言其<span style="color: black;">拥有</span>两大<span style="color: black;">优良</span>,<span style="color: black;">首要</span>,<span style="color: black;">咱们</span>能够观察到更好的免疫反应和抗肿瘤效应;其次,为了制造树突细胞疫苗,就<span style="color: black;">必须</span>从单核细胞<span style="color: black;">起始</span>,随后培养并处理细胞使其分化为树突细胞。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>者预测,单核细胞或许是将抗原运输到树突细胞的有效转运载体,但<span style="color: black;">她们</span>并<span style="color: black;">无</span>预料到单核细胞能够刺激机体强大的的T细胞反应;值得<span style="color: black;">重视</span>的是,当单核细胞利用一种名为缝隙连接(gap junction)的通路将抗原转运到脾脏中的树突细胞时,树突细胞就能靶向<span style="color: black;">功效</span>T细胞并有效<span style="color: black;">掌控</span>肿瘤的生长,缝隙连接能够<span style="color: black;">准许</span>不同的细胞之间进行连接。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>者Gunn说道,当<span style="color: black;">发掘</span>很强的免疫反应时<span style="color: black;">咱们</span>感到非常惊讶,<span style="color: black;">咱们</span>和其他人<span style="color: black;">同样</span>,都<span style="color: black;">必须</span><span style="color: black;">可疑</span><span style="color: black;">是不是</span><span style="color: black;">必须</span>注射树突细胞使其能够呈递抗原,但事实证明并不<span style="color: black;">必须</span>。后期<span style="color: black;">科研</span>人员还会进行更为深入的<span style="color: black;">科研</span>来阐明参与机体免疫反应的分子机制,<span style="color: black;">她们</span>计划于明年<span style="color: black;">起始</span>进行1期临床<span style="color: black;">实验</span>。<a style="color: black;"><span style="color: black;">返回<span style="color: black;">外链论坛:http://www.fok120.com/</span>,查看<span style="color: black;">更加多</span></span></a></p>
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