上海九院范先群课题组研发出“纳米武器”,实现对肿瘤的实时监控和有效治疗
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">BioWorld</strong>:据<strong style="color: blue;">国家癌症中心</strong>最新统计数据,我国恶性肿瘤新发病例为380.4万例/年,死亡病例229.6万/年,平均<span style="color: black;">每日</span>超过1万人被确诊为癌症,每分钟有7个人被确诊为癌症。详情见:国家癌症中心<span style="color: black;">颁布</span>最新中国恶性肿瘤发病和死亡分析。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌症的治疗<span style="color: black;">始终</span>是个<span style="color: black;">困难</span>,近年来随着科技的进步,<strong style="color: blue;">免疫治疗</strong>、<strong style="color: blue;">细胞治疗</strong>、<strong style="color: blue;">基因治疗</strong>以及<strong style="color: blue;">纳米技术</strong>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">等<span style="color: black;">逐步</span>应用于癌症治疗,并取得了一系列前所未有的辉煌成绩,人类距离<span style="color: black;">最后</span>战胜癌症的终极<span style="color: black;">目的</span>越来越近。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2017年,<strong style="color: blue;">Nature Nanotechnology</strong>(自然·纳米科技)杂志<span style="color: black;">发布</span>了一篇题为:In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers 的论文,<strong style="color: blue;"><span style="color: black;">运用</span>纳米材料将CAR表达质粒包裹后输入小鼠血液中,将小鼠<span style="color: black;">身体</span>的T细胞变成能够杀伤肿瘤的CAR-T细胞。该<span style="color: black;">科研</span>为CAR-T细胞治疗<span style="color: black;">供给</span>了一种新的思路</strong>。详情见:CAR-T新策略:纳米颗粒携带CAR载体在<span style="color: black;">身体</span>产生CAR-T细胞</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">纳米材料在癌症治疗中有着巨大的前景,但纳米材料的<strong style="color: blue;">低特异性</strong>很大程度上限制了它的应用和推广,<span style="color: black;">怎样</span><strong style="color: blue;"><span style="color: black;">精细</span>定位</strong>并杀灭肿瘤细胞,<span style="color: black;">同期</span>实现治疗过程中肿瘤病灶的<strong style="color: blue;">实时监控</strong>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">作为</span>当今癌症治疗中的<span style="color: black;">要紧</span><span style="color: black;">困难</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">近期</span>,上海交通大学医学院<span style="color: black;">附庸</span><strong style="color: blue;">第九人民医院</strong>眼科重点实验室的<strong style="color: blue;">范先群</strong>、<strong style="color: blue;">周慧芳</strong>课题组与中科院上海微系统与信息技术<span style="color: black;">科研</span>所<strong style="color: blue;">丁古巧</strong>课题组合作,在<strong style="color: blue;">Advanced Functional Materials</strong>杂志(IF=12.124)<span style="color: black;">发布</span>题为:Emancipating Target-Functionalized Carbon Dots from Autophagy Vesicles for a Novel Visualized Tumor Therapy的<span style="color: black;">科研</span>论文,该<span style="color: black;">科研</span>设计制备了表面修饰的C3N量子点(FN-CDs),<strong style="color: blue;"><span style="color: black;">经过</span>FN-CDs与临床常用的氯喹(CQ)联用,切断肿瘤细胞的自我<span style="color: black;">守护</span>途径,</strong><strong style="color: blue;">实现了肿瘤的可视化<span style="color: black;">有效</span>智能治疗</strong>。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic4.zhimg.com/80/v2-3daa7f957a0cff0ccedaa77e8e5c235f_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic1.zhimg.com/80/v2-39385da6a52714e2afbc0952c4bfbbdc_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">据说</span>,<strong style="color: blue;">李吉鹏</strong>为该论文<span style="color: black;">第1</span>作者,<strong style="color: blue;">范先群</strong>为通讯作者,<strong style="color: blue;">康振辉</strong>、<strong style="color: blue;">丁古巧</strong>、<strong style="color: blue;">周慧芳</strong>为<span style="color: black;">一起</span>通讯作者,杨思维和邓远为此<span style="color: black;">科研</span>做出了<span style="color: black;">要紧</span>贡献。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这是<strong style="color: blue;">范先群</strong>课题组近期继<strong style="color: blue;">Nucleic Acids Research</strong><span style="color: black;">发布</span>关于视网膜母细胞瘤新致病区<span style="color: black;">科研</span><span style="color: black;">文案</span>后的又一项<span style="color: black;">要紧</span><span style="color: black;">发展</span>。</p>
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