八大肝癌靶向药物引起的不良反应，为您一网打尽
<img src="https://mmbiz.qpic.cn/mmbiz_jpg/gLO8dn9uIfTytBEtcEicPTjWzOsWCmBpeP5ibIN3C8pr9wmF1lX2vRibxoGTejDLO1O12JxhYIHGZL2AOoyO8ms3w/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/gLO8dn9uIfT7mCyKlR9uk6bIDWhib2q1athiaia0QuDbqIhbFnQl0ibkfw1TfDviaHe96S5xyibY2VI4TUqAsl4tHuYw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/gLO8dn9uIfT7mCyKlR9uk6bIDWhib2q1ajffrR0sbiassuddJQ5Fv7l7bRBkmicLeHmSrmbnHicPKPqNMkBN0bkMQg/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">自2007年索拉非尼<span style="color: black;">获准</span><span style="color: black;">败兴</span>，靶向<span style="color: black;">药品</span><span style="color: black;">始终</span>占据着肝癌治疗的半壁江山，但随之而来的不良反应<span style="color: black;">亦</span>深深<span style="color: black;">困惑</span>着广大肝癌<span style="color: black;">病人</span>。今天<span style="color: black;">博主</span>在<span style="color: black;">安身</span>于《新型抗肿瘤<span style="color: black;">药品</span>临床应用<span style="color: black;">指点</span>原则（2019年版）》<span style="color: black;">基本</span>上，给<span style="color: black;">大众</span>整理了国内<span style="color: black;">获准</span>用于治疗肝癌<span style="color: black;">关联</span>的靶向治疗<span style="color: black;">药品</span>(索拉非尼、瑞戈非尼和仑伐替尼)以及在<span style="color: black;">实质</span>临床应用中常用的两大靶向<span style="color: black;">药品</span>（阿帕替尼和安罗替尼）的临床应用<span style="color: black;">指点</span>原则以及<span style="color: black;">药品</span>带来的<span style="color: black;">平常</span>不良反应，如腹泻、乏力、手足皮肤反应等处理<span style="color: black;">办法</span>，为<span style="color: black;">大众</span>排忧解难。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">1、</span>五大国内肝癌<span style="color: black;">病人</span>常用靶向<span style="color: black;">药品</span>不良反应<span style="color: black;">到底</span>有<span style="color: black;">那些</span>？</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">一线治疗靶向药</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">1、索拉非尼（sorafenib）</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">恰当</span>用药要点：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">举荐</span><span style="color: black;">吃下</span>剂量为每次400mg、每日两次，空腹或伴低脂、中脂<span style="color: black;">膳食</span><span style="color: black;">吃下</span>，对疑似不良反应的处理<span style="color: black;">包含</span>暂停或减少用量，如需减少剂量，索拉非尼的剂量减为每日一次，每次400mg，口服。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">平常</span>的不良反应：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">手足综合症（52％）、腹泻（46％）、高血压（30％）和食欲下降（27％）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">2、仑伐替尼（lenvatinib）</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">恰当</span>用药要点：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">1.仑伐替尼在肝癌的药代动力学在临床上<span style="color: black;">受到体重的<span style="color: black;">明显</span>影响</span>：</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">针对</span><span style="color: black;">体重＜60<span style="color: black;">公斤</span></span>的<span style="color: black;">病人</span>，<span style="color: black;">举荐</span>日剂量为<span style="color: black;">8mg</span>，每日一次；</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">针对</span><span style="color: black;">体重＞60<span style="color: black;">公斤</span></span>的<span style="color: black;">病人</span>，<span style="color: black;">举荐</span>日剂量为<span style="color: black;">12mg</span>，每日一次。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2、仑伐替尼应在<span style="color: black;"><span style="color: black;">每日</span>固<span style="color: black;">按时</span>间<span style="color: black;">吃下</span>，空腹或与<span style="color: black;">食品</span>同服均可</span>。<span style="color: black;">倘若</span><span style="color: black;">病人</span>遗漏一次用药且<span style="color: black;">没</span>法在12小时内<span style="color: black;">吃下</span>，<span style="color: black;"><span style="color: black;">没</span>需补服，应按常规用药时间进行下一次服药</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">最<span style="color: black;">平常</span>的不良反应：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">高血压、疲乏、腹泻、食欲下降、体重降低、关节痛/肌痛、腹痛、掌跖红肿<span style="color: black;">综合症</span>、蛋白尿、<span style="color: black;">流血</span>事件、发音困难、甲状腺功能<span style="color: black;">衰退</span>症、恶心，严重的不良反应<span style="color: black;">包含</span>肝衰竭、脑<span style="color: black;">流血</span>、<span style="color: black;">呼气</span>衰竭。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">二线治疗靶向药：</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">1、瑞戈非尼 regorafenib</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">恰当</span>用药要点：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1、 用药前<span style="color: black;">没</span>需进行基因检测。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2、 <span style="color: black;">药物</span>说明书<span style="color: black;">举荐</span>剂量为160mg口服，每日一次，<span style="color: black;"><span style="color: black;">意见</span>与<span style="color: black;">食品</span>同服</span>，用药3周停药1周。基于个人的安全及耐受性<span style="color: black;">思虑</span>，<span style="color: black;">可能<span style="color: black;">必须</span>中断或降低剂量，<span style="color: black;">亦</span><span style="color: black;">能够</span><span style="color: black;">思虑</span>采用80～120mg<span style="color: black;">初始</span>剂量<span style="color: black;">逐步</span>递增。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">最<span style="color: black;">平常</span>的不良反应：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">手足皮肤反应、肝功能<span style="color: black;">反常</span>（高胆红素血症、丙氨酸氨基转移酶<span style="color: black;">上升</span>、门冬氨酸氨基转移酶<span style="color: black;">上升</span>）和高血压，<span style="color: black;">同期</span>，还要<span style="color: black;">重视</span><span style="color: black;">病痛</span>、乏力、腹泻、食欲下降及进食减少等不良反应；最严重的不良反应为重度肝功能<span style="color: black;">损害</span>、<span style="color: black;">流血</span>、胃肠道穿孔及感染；有血栓、栓塞病史者应<span style="color: black;">小心</span><span style="color: black;">运用</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">暂未<span style="color: black;">获准</span>肝癌靶向药：</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">以下<span style="color: black;">药品</span>都是<span style="color: black;">准许</span><span style="color: black;">日前</span>已<span style="color: black;">获准</span>用于其他癌种的靶向<span style="color: black;">药品</span>，但在<span style="color: black;">实质</span>临床应用中<span style="color: black;">亦</span>有肝癌<span style="color: black;">病人</span><span style="color: black;">运用</span>，<span style="color: black;">因此</span><span style="color: black;">咱们</span>将其不良反应<span style="color: black;">亦</span>做一次简单介绍。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">1、阿帕替尼（apatinib）</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">恰当</span>用药要点：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1、 <span style="color: black;">药物</span>说明书<span style="color: black;">举荐</span>剂量为850mg，每日一次。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">体能差的<span style="color: black;">病人</span><span style="color: black;">能够</span>适当降低<span style="color: black;">初始</span>剂量</span>，先从250mg<span style="color: black;">起始</span>服药，<span style="color: black;">吃下</span>1～2周后再酌情<span style="color: black;">增多</span>剂量。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2、<span style="color: black;"><span style="color: black;">运用</span>过程中<span style="color: black;">显现</span>3～4级不良反应时，<span style="color: black;">意见</span>暂停用药，并对症处理，待症状缓解恢复到1级以内，随后降低剂量<span style="color: black;">吃下</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">平常</span>的不良反应：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">用药<span style="color: black;">时期</span><span style="color: black;">必要</span><span style="color: black;">尤其</span>关注血压<span style="color: black;">上升</span>、蛋白尿、手足皮肤反应、<span style="color: black;">流血</span>、心脏毒性、肝脏毒性等不良反应。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">2、安罗替尼（anlotinib）</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">恰当</span>用药要点：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1、 安罗替尼<span style="color: black;">有<span style="color: black;">增多</span><span style="color: black;">出现</span><span style="color: black;">流血</span>事件和<span style="color: black;">出现</span>血栓/栓塞事件的<span style="color: black;">危害</span></span>，<span style="color: black;">因此呢</span>，<span style="color: black;">拥有</span><span style="color: black;">流血</span><span style="color: black;">危害</span>、凝血功能<span style="color: black;">反常</span>的<span style="color: black;">病人</span>、<span style="color: black;">拥有</span>血栓/卒中病史的<span style="color: black;">病人</span>以及<span style="color: black;">吃下</span>抗凝<span style="color: black;">药品</span>及<span style="color: black;">关联</span><span style="color: black;">疾患</span>的<span style="color: black;">病人</span>应慎用。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">最<span style="color: black;">平常</span>的不良反应：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">用药<span style="color: black;">时期</span>应密切关注高血压的<span style="color: black;">出现</span>，常规降压<span style="color: black;">药品</span>可有效<span style="color: black;">掌控</span><span style="color: black;">病人</span>血压。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">2、</span>靶向<span style="color: black;">药品</span><span style="color: black;">显现</span>不良反应怎么办？</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">下面<span style="color: black;">咱们</span>就<span style="color: black;">病人</span>最常<span style="color: black;">显现</span>的不良反应给<span style="color: black;">大众</span>做一个归纳<span style="color: black;">处理</span><span style="color: black;">方法</span></span></p><img src="https://mmbiz.qpic.cn/mmbiz_png/gLO8dn9uIfT7mCyKlR9uk6bIDWhib2q1ae9LBdoNLDoCUJVD05ib37iabe5ymtib4gQvHBTUxJHibGM0092tGichGgSQ/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">1、手足<span style="color: black;">综合症</span></strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">首要</span>，<span style="color: black;">倘若</span>手脚<span style="color: black;">显现</span>了<span style="color: black;">病痛</span>、对<span style="color: black;">叫作</span>性红斑以及掌心、脚底红肿脱皮<span style="color: black;">或</span>过度角质化的<span style="color: black;">状况</span>，就很可能<span style="color: black;">显现</span>了手足<span style="color: black;">综合症</span>不良反应。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">大众</span><span style="color: black;">能够</span>在患处涂抹资生堂尿素手足霜、香港二天堂拔毒生肌膏、凡士林软膏，口服维生素B6。脚跟肿痛脱皮<span style="color: black;">能够</span>涂扶他林。</span></p><img src="https://mmbiz.qpic.cn/mmbiz_png/gLO8dn9uIfT7mCyKlR9uk6bIDWhib2q1ackQKy5qpDAm7ulZiaA4bibpmISarCG0wmyPvl0U75gVdPTvEZsFpp5Ng/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">2、腹泻</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">还有一种<span style="color: black;">平常</span>症状，<span style="color: black;">便是</span>腹泻。<span style="color: black;">倘若</span><span style="color: black;">显现</span>了<span style="color: black;">能够</span>吃些止泻<span style="color: black;">药品</span>，避免体重减轻和脱水，<span style="color: black;">通常</span><span style="color: black;">状况</span>下症状会消失。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">倘若</span><span style="color: black;">根据</span><span style="color: black;">以上</span>办法<span style="color: black;">没</span>法减轻腹泻，则要咨询<span style="color: black;">大夫</span>，<span style="color: black;">思虑</span><span style="color: black;">调节</span>剂量或临时中断治疗。在<span style="color: black;">吃下</span>靶向<span style="color: black;">药品</span><span style="color: black;">时期</span>，<span style="color: black;">亦</span>要<span style="color: black;">重视</span>多喝水，少食多餐，更要避免食用辛辣<span style="color: black;">食品</span>、奶制品等</span>。</p><img src="https://mmbiz.qpic.cn/mmbiz_png/gLO8dn9uIfT7mCyKlR9uk6bIDWhib2q1a8zSN4abfeI443bEl79MlX0pEphNkVRibBuKY9icYLKXQwH8xwNCXxtZA/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">3、高血压</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">对应用抗血管生成<span style="color: black;">药品</span>后新发的高血压病人<span style="color: black;">能够</span><span style="color: black;">运用</span>钙离子拈抗剂<span style="color: black;">掌控</span>血压，如安内真（苯磺酸氨氯地平片）、拜新同（硝苯地平控释片）；</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">血压<span style="color: black;">掌控</span>稳定的病人<span style="color: black;">倘若</span>在接受抗血管生成<span style="color: black;">药品</span>治疗后<span style="color: black;">显现</span>血压<span style="color: black;">上升</span>，应<span style="color: black;">思虑</span>原有降压药加量或加用另一种降压<span style="color: black;">药品</span>。如口服降压药<span style="color: black;">没</span>法<span style="color: black;">掌控</span>高血压，则应终止抗血管生成<span style="color: black;">药品</span>的<span style="color: black;">运用</span>；</span></p><img src="https://mmbiz.qpic.cn/mmbiz_png/gLO8dn9uIfT7mCyKlR9uk6bIDWhib2q1aCRCibHfpmWpUE1OetRsGJwibUVMa7sFtJYuzxVrFUl59C4ibyPDiaCcvlA/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">4、乏力</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">倘若</span>在服药<span style="color: black;">时期</span>，经常感到身体乏力，提不起精神，<span style="color: black;">乃至</span>做<span style="color: black;">平常</span>小事都感到<span style="color: black;">疲劳</span>，就要<span style="color: black;">警觉</span>是不是得了疲乏的不良反应。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">倘若</span>只是轻度的疲乏，<span style="color: black;">能够</span><span style="color: black;">经过</span>多<span style="color: black;">休憩</span>、<span style="color: black;">或</span>是多<span style="color: black;">熬炼</span>，来<span style="color: black;">加强</span>身体的免疫力。<span style="color: black;">或</span>吃<span style="color: black;">有些</span><span style="color: black;">药品</span>治疗，<span style="color: black;">例如</span>，改善甲状腺功能<span style="color: black;">衰退</span>的<span style="color: black;">药品</span>，可能<span style="color: black;">状况</span>会有所改善。但<span style="color: black;">倘若</span><span style="color: black;">状况</span><span style="color: black;">尤其</span>严重，就<span style="color: black;">必须</span>咨询<span style="color: black;">大夫</span>来做针对性的治疗了。</span></p><img src="https://mmbiz.qpic.cn/mmbiz_png/gLO8dn9uIfT7mCyKlR9uk6bIDWhib2q1a1pEh7XUMKLoPkHy1Gicr7fJbsFmnNHyUj2SwBk0hQFbnX2OdCTVruJA/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">5、恶心呕吐</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">营养<span style="color: black;">膳食</span>很<span style="color: black;">要紧</span>，癌症<span style="color: black;">病人</span>想保持健康的<span style="color: black;">膳食</span>和适当的<span style="color: black;">膳食</span>习惯很困难。恶心、呕吐会影响治疗和生活质量。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">治疗前<span style="color: black;">运用</span>止吐药，<span style="color: black;">亦</span><span style="color: black;">能够</span>在治疗结束后继续用几天，咨询<span style="color: black;">大夫</span><span style="color: black;">详细</span>用药。<span style="color: black;">倘若</span>一旦<span style="color: black;">起始</span>感到胃部不适，立即<span style="color: black;">吃下</span>止吐药，不要等到恶心恶化。<span style="color: black;">倘若</span>用药后还恶心，立即告诉<span style="color: black;">大夫</span>，以便考虑替代止吐药或不同的<span style="color: black;">药品</span>组合。还<span style="color: black;">能够</span>询问您的<span style="color: black;">大夫</span><span style="color: black;">相关</span>针灸或针灸的信息。有些人<span style="color: black;">发掘</span>它<span style="color: black;">能够</span><span style="color: black;">帮忙</span>缓解恶心。</span></p><img src="https://mmbiz.qpic.cn/mmbiz_png/gLO8dn9uIfT7mCyKlR9uk6bIDWhib2q1ajCfnF9aahZGt7sQs8EGyAvMIMHEKFG4EXdBhiaib5QvpTicddfyfjEKhA/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">6、<span style="color: black;">流血</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">通常</span>是肿瘤<span style="color: black;">关联</span>的<span style="color: black;">流血</span>和微量黏膜与皮肤<span style="color: black;">流血</span>。在治疗<span style="color: black;">时期</span>，这类副<span style="color: black;">功效</span><span style="color: black;">通常</span>都很轻，<span style="color: black;">没</span>须处理就可恢复。但对严重中枢神经<span style="color: black;">流血</span>或其他部位 3／4 度<span style="color: black;">流血</span>，应立即终止治疗。</span></p><img src="https://mmbiz.qpic.cn/mmbiz_png/gLO8dn9uIfT7mCyKlR9uk6bIDWhib2q1aQZ2AfdJKHpo3DF0iah1edFrfg0cloA1p7HFqCg0pIjWRibePkobgtVSw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">7、蛋白尿</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">如<span style="color: black;">果是在上厕所的时候，发现尿中有<span style="color: black;">泡泡</span>，<span style="color: black;">况且</span>这些<span style="color: black;">泡泡</span><span style="color: black;">通常</span>会<span style="color: black;">连续</span>很久，<span style="color: black;">不易</span>消失。那可能是<span style="color: black;">显现</span>了蛋白尿的不良反应。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">病人</span>一旦<span style="color: black;">发掘</span>因去医院就诊，监测下尿蛋白的含量。<span style="color: black;">倘若</span>在24小时尿蛋白定量检测中，尿蛋白大于2g，就要立刻暂停靶向<span style="color: black;">药品</span>的<span style="color: black;">运用</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">8、血栓栓塞</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">为防止血栓栓塞的<span style="color: black;">出现</span>，在治疗<span style="color: black;">时期</span><span style="color: black;">病人</span>因多下床活动，<span style="color: black;">按时</span>对下肢进行局部按摩，并密切监测<span style="color: black;">病人</span>的血压及血栓栓塞<span style="color: black;">关联</span>症状的<span style="color: black;">状况</span>，<span style="color: black;">尤其</span>是年龄大于 65 岁的老年<span style="color: black;">病人</span>。如<span style="color: black;">显现</span>血栓<span style="color: black;">出现</span>的症状和体征，应给予正确的溶栓抗凝治疗，并停用抗 VEGF <span style="color: black;">药品</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">以上<span style="color: black;">便是</span>靶向药<span style="color: black;">平常</span>副<span style="color: black;">功效</span>的缓解<span style="color: black;">办法</span>啦，<span style="color: black;">大众</span><span style="color: black;">能够</span>参考一下，<span style="color: black;">不外</span><span style="color: black;">由于</span><span style="color: black;">每一个</span>人的体质和身体耐受<span style="color: black;">状况</span>的差异，在<span style="color: black;">运用</span><span style="color: black;">药品</span>的时候<span style="color: black;">必定</span>要事先和<span style="color: black;">大夫</span>确认好剂量和使用<span style="color: black;">办法</span>哦。<span style="color: black;">平常</span>的副<span style="color: black;">功效</span><span style="color: black;">咱们</span><span style="color: black;">能够</span><span style="color: black;">经过</span><span style="color: black;">有些</span>小<span style="color: black;">办法</span>来缓解，当身体<span style="color: black;">显现</span>严重不适时，要<span style="color: black;">即时</span><span style="color: black;">看病</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">参考文献：</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">1、新型抗肿瘤<span style="color: black;">药品</span>临床应用<span style="color: black;">指点</span>原则（2019年版）</span></p><img src="data:image/svg+xml,%3C%3Fxml version=1.0 encoding=UTF-8%3F%3E%3Csvg width=1px height=1px viewBox=0 0 1 1 version=1.1 xmlns=http://www.w3.org/2000/svg xmlns:xlink=http://www.w3.org/1999/xlink%3E%3Ctitle%3E%3C/title%3E%3Cg stroke=none stroke-width=1 fill=none fill-rule=evenodd fill-opacity=0%3E%3Cg transform=translate(-249.000000, -126.000000) fill=%23FFFFFF%3E%3Crect x=249 y=126 width=1 height=1%3E%3C/rect%3E%3C/g%3E%3C/g%3E%3C/svg%3E" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">声明：本资料中<span style="color: black;">触及</span>的信息仅供参考，请遵从<span style="color: black;">大夫</span>或其他医疗卫生专业人士的意见或<span style="color: black;">指点</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本文版权归国际肝胆<span style="color: black;">新闻</span>所有，任何个人或<span style="color: black;">公司</span>转载需<span style="color: black;">得到</span><span style="color: black;">国际肝胆<span style="color: black;">新闻</span></span>授权，在授权范围内<span style="color: black;">运用</span>，并标注<span style="color: black;">源自</span>“<span style="color: black;">国际肝胆<span style="color: black;">新闻</span></span>”。</p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">（PS：管理员繁忙，请备注癌种、<span style="color: black;">经过</span>验证后方可入群）</strong></p><img src="https://mmbiz.qpic.cn/mmbiz_png/gLO8dn9uIfT7mCyKlR9uk6bIDWhib2q1aJyrv7OzCoNLDvjrgBQj6cOucaBJ9L2VDv0pthGjvEZWQ3icQSdUTGdA/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/gLO8dn9uIfT7mCyKlR9uk6bIDWhib2q1avWrKNWRdlicBAFUbItt1KVib0v217qB4lfOfRF2WRd9JEFF89dquickEg/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
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