癌症科研最新发展(2021年9月)
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【1】CANCER IMMUNOL IMMUN:揭秘前列腺癌放疗后免疫<span style="color: black;">关联</span>基因的<span style="color: black;">长时间</span>表达变化! 2021-09-06 </p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">近期,Iris Eke教授及其团队<span style="color: black;">发掘</span>了免疫<span style="color: black;">关联</span>基因表达的变化受到放疗<span style="color: black;">方法</span>的影响,这些<span style="color: black;">发掘</span>对去势难治性前列腺癌<span style="color: black;">病人</span>的免疫治疗<span style="color: black;">拥有</span><span style="color: black;">要紧</span><span style="color: black;">道理</span>。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic2.zhimg.com/80/v2-0b2b8a3fe52aa6a5475f6a976b4adb49_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">为了确定照射后基因表达的<span style="color: black;">长时间</span>变化,<span style="color: black;">科研</span>人员对PC3 (p53缺失)和LNCaP (p53野生型)前列腺癌细胞进行单剂量(SD, 10gy)或10份(每份1gy)的分步治疗(MF)照射。测定辐照后24小时和2个月的基因表达,并对免疫通路激活<span style="color: black;">状况</span>进行分析。<span style="color: black;">另外</span>,进行3D菌落形成<span style="color: black;">实验</span>和T细胞细胞毒性<span style="color: black;">实验</span>。与PC3相比,LNCaP<span style="color: black;">拥有</span>更高的免疫原性基因<span style="color: black;">基本</span>表达,且更能被细胞毒T细胞杀灭。在两种细胞系中,MF(分布治疗)辐照后会<span style="color: black;">引起</span>多个免疫<span style="color: black;">关联</span>基因的表达立即<span style="color: black;">增多</span>,而SD(单剂量)辐照对辐射诱导的基因表达的影响在两个月后会更<span style="color: black;">显著</span>。PC3细胞经10gy SD照射后免疫原性和免疫<span style="color: black;">控制</span>基因均上调,但LNCaP未上调。与未辐照对照相比, SD(10Gy)照射的PC3细胞中T细胞介导的细胞毒性<span style="color: black;">明显</span><span style="color: black;">增多</span>,并可<span style="color: black;">经过</span>免疫<span style="color: black;">检测</span>点<span style="color: black;">控制</span>剂进一步<span style="color: black;">加强</span>其<span style="color: black;">功效</span>。</p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">单剂量(SD)和多分馏(MF)照射的时间线</p>照射以分级依赖的方式影响癌细胞中免疫<span style="color: black;">关联</span>基因的表达。<span style="color: black;">认识</span>这些变化可能是治疗原发性前列腺癌和复发性肿瘤的一个切入点。总的<span style="color: black;">来讲</span>,该<span style="color: black;">科研</span>结果<span style="color: black;">显示</span>,辐射<span style="color: black;">能够</span>以分级依赖的方式调节癌细胞中免疫<span style="color: black;">关联</span>基因的表达。<span style="color: black;">科研</span>这些变化并且联合免疫疗法可能是治疗复发性肿瘤(<span style="color: black;">尤其</span>是前列腺癌)的一种有前途的新<span style="color: black;">办法</span>。
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文:Eke I, Aryankalayil MJ, et al. Long-term expression changes of immune-related genes in prostate cancer after radiotherapy. Cancer Immunol Immunother. 2021 Aug 25. doi: 10.1007/s00262-021-03036-w.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【2】JNCI:<span style="color: black;">运用</span>抗生素或会<span style="color: black;">增多</span>人群患结肠癌的<span style="color: black;">危害</span> 2021-09-04</p>来自瑞典于默奥大学等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span>旨在调查抗生素的<span style="color: black;">运用</span>和机体随后患结直肠癌<span style="color: black;">危害</span>之间的<span style="color: black;">相关</span>。
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">有<span style="color: black;">科研</span>证据<span style="color: black;">显示</span>,抗生素或能<span style="color: black;">经过</span>改变肠道菌群来<span style="color: black;">增多</span>机体患结直肠癌的<span style="color: black;">危害</span>,<span style="color: black;">近期</span>,一篇<span style="color: black;">发布</span>在国际杂志Journal of the National Cancer Institute上题为“Antibiotics Use and Subse</p>
哈哈、笑死我了、太搞笑了吧等。
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