tw4ld6 发表于 2024-6-26 07:09:28

晚期肿瘤治疗有效率96%!武汉协和医院团队创新治疗成果获国际认可


    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">近期</span>,</span><strong style="color: blue;"><span style="color: black;">华中科技大学同济医学院<span style="color: black;">附庸</span>协和医院(以下简<span style="color: black;">叫作</span>“武汉协和医院”)头颈部肿瘤多学科诊疗(MDT)团队</span></strong><span style="color: black;">,在<span style="color: black;">全世界</span>癌症治疗<span style="color: black;">行业</span>重点期刊《临床癌症<span style="color: black;">科研</span>》(Clinical Cancer Research)上<span style="color: black;">发布</span>了<span style="color: black;">全世界</span>首个应用新辅助化疗联合程序性死亡受体(PD-1)抗体治疗局部晚期头颈部鳞癌的临床<span style="color: black;">科研</span>数据。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">科研</span>结果<span style="color: black;">表示</span>肿瘤有效率达96%,病理完全缓解率达37%,<span style="color: black;">显著</span>病理缓解(MPR)(病理&gt;90%缓解)率74%;远超历史治疗<span style="color: black;">方法</span>的影像和病理缓解率。新辅助化疗联合免疫治疗模式可<span style="color: black;">明显</span><span style="color: black;">加强</span><span style="color: black;">病人</span>的肿瘤治愈率,减少<span style="color: black;">病人</span>肿瘤部位<span style="color: black;">例如</span>喉、口腔、口咽这些<span style="color: black;">要紧</span>器官的<span style="color: black;">损害</span>,为头颈部鳞癌<span style="color: black;">病人</span><span style="color: black;">供给</span>了一种新的治疗<span style="color: black;">选取</span>。</span></p><strong style="color: blue;">做中国人的原创<span style="color: black;">科研</span>,推动世界头颈部鳞癌治疗发展</strong>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">头颈部鳞癌是我国第九大<span style="color: black;">平常</span>癌症,年新发增发病人数约14.2万,治疗难度比<span style="color: black;">很强</span>。武汉协和医院肿瘤科<span style="color: black;">专家</span>杨坤禹教授介绍,</span><strong style="color: blue;"><span style="color: black;">我国超过60%的头颈肿瘤<span style="color: black;">病人</span>初诊时都<span style="color: black;">处在</span>局部晚期</span></strong><span style="color: black;">,这部分<span style="color: black;">病人</span>治疗后超过一半会<span style="color: black;">显现</span>肿瘤复发或转移,复发转移<span style="color: black;">病人</span><span style="color: black;">存活</span>时间仅14个月<span style="color: black;">上下</span>。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">针对</span>局部晚期的头颈部鳞癌<span style="color: black;">病人</span>,国际和国内指南<span style="color: black;">举荐</span>的治疗模式是根治性手术联合术后放疗,<span style="color: black;">或</span>是根治性同期放化疗,5年<span style="color: black;">存活</span>率约40%,疗效显然<span style="color: black;">不可</span>令人满意。<span style="color: black;">况且</span>,根治性手术后,舌、咽部和喉部等<span style="color: black;">要紧</span>器官的切除常常<span style="color: black;">引起</span>严重的功能<span style="color: black;">阻碍</span>,<span style="color: black;">病人</span>生活质量差。<span style="color: black;">因此呢</span>,探索新型治疗模式,<span style="color: black;">加强</span>局部晚期头颈部鳞癌<span style="color: black;">病人</span><span style="color: black;">存活</span>率,改善<span style="color: black;">病人</span>生活质量,是亟须<span style="color: black;">处理</span>的<span style="color: black;">困难</span>。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">经过3年<span style="color: black;">科研</span>,武汉协和医院头颈部肿瘤MDT团队首创了一种新型治疗模式,将头颈部鳞癌治疗水平向前推进了一大步。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">为<span style="color: black;">加强</span>肿瘤治愈率,武汉协和医院针对多个瘤种组<span style="color: black;">成为了</span>多学科联合诊疗团队。该<span style="color: black;">科研</span>由武汉协和医院在肿瘤头颈肿瘤MDT团队<span style="color: black;">一起</span>完成。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">每一例在武汉协和医院就诊的头颈鳞癌<span style="color: black;">病人</span>,<span style="color: black;">没</span>论是在外科还是肿瘤科住院,在完善<span style="color: black;">检测</span>后,病情数据均提交给由耳鼻喉头颈外科、口腔科、肿瘤科、影像科和病理科专家们<span style="color: black;">构成</span>的MDT团队<span style="color: black;">一起</span>讨论,制定治疗决策。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">符合<span style="color: black;">科研</span><span style="color: black;">前提</span>的<span style="color: black;">病人</span>,先接受三疗程新辅助化疗联合免疫治疗后,再接受根治性手术。在新辅助免疫化疗<span style="color: black;">时期</span>,<span style="color: black;">科研</span>团队会多次把治疗后肿瘤的反应<span style="color: black;">状况</span>提交MDT做多轮讨论和评估。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">新辅助化疗联合免疫治疗的目的是使肿瘤体积<span style="color: black;">快速</span>缩小<span style="color: black;">乃至</span>消失,使其<span style="color: black;">更易</span>被完整切除,并清除<span style="color: black;">病人</span><span style="color: black;">身体</span>的微小转移病灶。<span style="color: black;">况且</span>,免疫治疗<span style="color: black;">拥有</span>记忆效应,一旦有效,<span style="color: black;">能够</span><span style="color: black;">长时间</span><span style="color: black;">监测</span>肿瘤细胞,清除肿瘤复发或转移病灶。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">免疫治疗<span style="color: black;">运用</span>一种PD-1抗体,它<span style="color: black;">能够</span>恢复免疫细胞对肿瘤细胞的杀伤<span style="color: black;">功效</span>,逆转肿瘤细胞的免疫逃逸。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">这种新型治疗策略确实能够使局部晚期头颈鳞癌<span style="color: black;">病人</span>肿瘤<span style="color: black;">明显</span>退缩,<span style="color: black;">乃至</span>消失,从而能够被完全切除,并可能<span style="color: black;">得到</span>器官功能<span style="color: black;">保存</span>,且有更高的治愈机会,从而<span style="color: black;">提高</span>了局部晚期头颈部鳞癌的整体疗效和<span style="color: black;">病人</span>的生活质量。</span></p><strong style="color: blue;">打破历史纪录,晚期肿瘤治疗有效率达96%</strong>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">科研</span>结果<span style="color: black;">表示</span>,新辅助化疗进一步联合免疫治疗能<span style="color: black;">得到</span>更好的疗效,肿瘤有效率达96%(历史数据60%~70%),病理完全缓解率达37%(历史数据10%),MPR(病理&gt;90%缓解)率74%;远超历史治疗<span style="color: black;">方法</span>的影像和病理缓解率。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">该<span style="color: black;">科研</span>的副反应良好可控,95%<span style="color: black;">病人</span><span style="color: black;">处在</span><span style="color: black;">连续</span>缓解状态。“将新疗法应用于新辅助治疗还有几方面益处,<span style="color: black;">包含</span>在术前缩小肿瘤,降低手术难度,减少手术并发症。术前免疫治疗可能还<span style="color: black;">拥有</span><span style="color: black;">加强</span>T细胞<span style="color: black;">起步</span>,促进抗肿瘤T细胞扩增的益处,<span style="color: black;">从而</span>可清除微小的癌症转移灶,这比在辅助治疗时<span style="color: black;">运用</span>效果更好”,杨坤禹教授解释。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/NFJOSUpfftbblgPrhVMdWUzAeOibOXU5UFChw2tBUJws7eib7eA6Yyy44BGblz42N9RCrsiatfs8KkxibnFlcG1a6A/640?tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">武汉协和医院肿瘤中心杨坤禹教授介绍<span style="color: black;">科研</span><span style="color: black;">状况</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">今年<span style="color: black;">已然</span>62岁的马先生(化名)<span style="color: black;">亦</span>是受试者之一。马先生人<span style="color: black;">叫作</span>“烟酒先生”,只因他平日嗜烟酒如命。2020年5月,因 “咽部异物感伴声音嘶哑、吞咽梗阻”就诊于武汉协和医院。经过<span style="color: black;">仔细</span><span style="color: black;">检测</span><span style="color: black;">发掘</span>,马先生下咽处肿瘤上下径达到5厘米,侵犯舌根、会咽、梨状窝等<span style="color: black;">周边</span>组织并且伴有颈部淋巴结转移,诊断为局部晚期下咽鳞癌,临床分期ⅣA期。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">“<span style="color: black;">根据</span>传统手术<span style="color: black;">办法</span>,像马先生<span style="color: black;">这般</span>的<span style="color: black;">病人</span>,<span style="color: black;">必须</span>全喉全下咽切除,术后即便恢复不错,但言语功能基本就丧失了,<span style="color: black;">况且</span>术后留下的永久性的伤口会严重影响<span style="color: black;">平常</span>社交生活,<span style="color: black;">病人</span>容易产生自卑<span style="color: black;">心情</span>”,另一位MDT团队负责人、耳鼻咽喉头颈外科张小萌教授介绍,曾有一位全喉切除的<span style="color: black;">病人</span>,来院复查时因自卑<span style="color: black;">心情</span>,<span style="color: black;">没</span>法与<span style="color: black;">大夫</span>面对面沟通。“好在有了前期的<span style="color: black;">科研</span><span style="color: black;">基本</span>,<span style="color: black;">咱们</span><span style="color: black;">能够</span>尝试新的路径。”经过3个周期新辅助化疗联合免疫治疗后,马先生的肿瘤病灶<span style="color: black;">明显</span>缩小,张小萌教授术前<span style="color: black;">评定</span>下咽病灶时,以期肿瘤累及范围内<span style="color: black;">已然</span><span style="color: black;">无</span>看到<span style="color: black;">知道</span>的肿瘤病变,在随后的手术标本中<span style="color: black;">亦</span>未找到肿瘤细胞。<span style="color: black;">最后</span>手术成功切除原发病灶,<span style="color: black;">同期</span>保住喉咙。术后马先生恢复良好,已回归正常生活。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/NFJOSUpfftbblgPrhVMdWUzAeOibOXU5UKz5mWicFM4ctwURUEYiacsOSDrnoiaWxwKTia2z889lqrOicDlAebtxq4icA/640?tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">武汉协和医院耳鼻喉科张小萌教授介绍<span style="color: black;">科研</span><span style="color: black;">状况</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/NFJOSUpfftbblgPrhVMdWUzAeOibOXU5UgN1ia3b00Zz1c3ZicdNPbJ2Xj79JSGbLlqeXsAETjkCTpEcCV1322yAA/640?tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">武汉协和医院放射科马辉副<span style="color: black;">专家</span>医师介绍<span style="color: black;">科研</span><span style="color: black;">状况</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/NFJOSUpfftbblgPrhVMdWUzAeOibOXU5Uict3YXXCc7X3EkdiabOiaibXfBxibareWvrNPHWXdMLQMjconOqcILNdpPw/640?tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">武汉协和医院病理科肖桂香医师介绍<span style="color: black;">科研</span><span style="color: black;">状况</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">“</span><strong style="color: blue;"><span style="color: black;">这<span style="color: black;">便是</span><span style="color: black;">咱们</span><span style="color: black;">科研</span>的<span style="color: black;">道理</span>,晚期头颈肿瘤再难<span style="color: black;">解决</span>,<span style="color: black;">咱们</span><span style="color: black;">亦</span>要‘死磕’这块硬骨头</span></strong><span style="color: black;">。”<span style="color: black;">日前</span>,像马先生<span style="color: black;">这般</span>的<span style="color: black;">病人</span>,团队<span style="color: black;">已然</span>治愈了50余例。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">武汉协和医院头颈部肿瘤MDT团队成立<span style="color: black;">已然</span>有七年了,整合了耳鼻喉头颈外科、口腔科、肿瘤放化疗科、整形美容科、病理科、影像科、核医学科等多个专家团队,<span style="color: black;">一起</span>讨论<span style="color: black;">病人</span>的病情,为<span style="color: black;">病人</span>制定最个体化的、科学的最佳治疗<span style="color: black;">方法</span>。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/NFJOSUpfftbblgPrhVMdWUzAeOibOXU5UVyLkXickEefHnyziapjVh6olXm4Cicsic0wibHR3u6gJY6hFOOdcnnZclxw/640?tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">武汉协和医院党委宣传部王继亮部长阐述<span style="color: black;">科研</span><span style="color: black;">道理</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">将来</span>,团队将继续致力于晚期和复发性头颈部鳞状细胞癌免疫治疗的<span style="color: black;">基本</span>与临床<span style="color: black;">科研</span>,为广大肿瘤<span style="color: black;">病人</span>创造治愈的机会,<span style="color: black;">持续</span><span style="color: black;">加强</span><span style="color: black;">病人</span>生活质量,为<span style="color: black;">病人</span>带来新的<span style="color: black;">期盼</span>。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/NFJOSUpfftbblgPrhVMdWUzAeOibOXU5ULZcuAzpiacHN8H9qwEmcEWSTYgqoSmsL3wxSKLic57wDItDzr7tqMBqg/640?tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/NFJOSUpfftbblgPrhVMdWUzAeOibOXU5U2fOYJQnaM1Syibl24a6LaPz8ATTvHa0O2v0mRias9A0egzf1rr6WcibRQ/640?tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">两位恢复良好的<span style="color: black;">病人</span>在现场参与交流</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">通讯员&nbsp;&nbsp;华中科技大学同济医学院<span style="color: black;">附庸</span>协和医院<span style="color: black;">张玮&nbsp; 熊婉婷&nbsp;</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">摄像&nbsp; 华中科技大学同济医学院<span style="color: black;">附庸</span>协和医院&nbsp; 刘坤维</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/NFJOSUpfftbblgPrhVMdWUzAeOibOXU5UT2aErjq55jyicoicQpbyH0mu4awP7U4Y21WwbJxkibz4ozw163iaOQuJuA/640?tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>




1fy07h 发表于 2024-10-8 13:54:44

期待与你深入交流,共探知识的无穷魅力。

b1gc8v 发表于 2024-10-23 11:03:03

我赞同你的看法,你的智慧让人佩服,谢谢分享。
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